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originally posted by: andy06shake
a reply to: thethinkingman
And how does the above constitute the Oxford AstraZeneca vaccine being gene therapy given that the vaccine functions by using "a harmless virus that has been altered to have the SARS-CoV-2 protein" on its surface alone?
Where are the deliberate changes made to the DNA given that the vaccine never enters the nucleus of the cell or interacts with the person's DNA?
Gene therapies permanently change a cells DNA, are you claiming that's what the viral vector AstraZeneca vaccine or any other COVID-19 mRNA vaccine does?
originally posted by: andy06shake
a reply to: face23785
Everyone is entitled to their observations.
Was a little more than an anecdote for me though, more like 3 days of bloody murder, might have been short but there was certainly nothing amusing about the experience.
The virus was no joke, especially so when the hospitals were all full and refusing to admit any more patients down to being at capacity, which was a fact at the time.
originally posted by: andy06shake
a reply to: thethinkingman
Again "the mRNA from the vaccines does not enter the cell nucleus or interact with the DNA at all, so it does not constitute gene therapy.".
But please feel free to continue to prattle on.
"The email identified “a significant difference in % RNA integrity/truncated species” between the clinical batches and proposed commercial batches—from around 78% to 55%. The root cause was unknown and the impact of this loss of RNA integrity on safety and efficacy of the vaccine was “yet to be defined,” the email said.
Ultimately, on 21 December, EMA authorised Pfizer-BioNTech’s vaccine. The agency’s public assessment report, a technical document published on its website, noted, “the quality of this medicinal product, submitted in the emergency context of the current (covid-19) pandemic, is considered to be sufficiently consistent and acceptable.”2
It’s unclear how the agency’s concerns were satisfied.
According to one of the leaked emails dated 25 November, positive news had come from an undisclosed source in the US: “The latest lots indicate that % intact RNA are back at around 70-75%, which leaves us cautiously optimistic that additional data could address the issue,” the email said.
RNA instability is one of the biggest hurdles for researchers developing nucleic acid based vaccines. It is the primary reason for the technology’s stringent cold chain requirements and has been addressed by encapsulating the mRNA in lipid nanoparticles (box).
“The complete, intact mRNA molecule is essential to its potency as a vaccine,” professor of biopharmaceutics Daan J.A. Crommelin and colleagues wrote in a review article in The Journal of Pharmaceutical Sciences late last year.
“Even a minor degradation reaction, anywhere along a mRNA strand, can severely slow or stop proper translation performance of that strand and thus result in the incomplete expression of the target antigen.”
The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among unvaccinated individuals. These findings were more pronounced in older adults and individuals with pre-existing conditions. According to the European Medicines Agency’s recommendations, frequent COVID-19 booster shots could adversely affect the immune response and may not be feasible
The decrease in immunity is caused by several factors. First, N1-methylpseudouridine is used as a substitute for uracil in the genetic code. The modified protein may induce the activation of regulatory T cells, resulting in decreased cellular immunity.
Thereby, the spike proteins do not immediately decay following the administration of mRNA vaccines. The spike proteins present on exosomes circulate throughout the body for more than 4 months .
In addition, in vivo studies have shown that lipid nanoparticles (LNPs) accumulate in the liver, spleen, adrenal glands, and ovaries , and that LNP-encapsulated mRNA is highly inflammatory [7].
Newly generated antibodies of the spike protein damage the cells and tissues that are primed to produce spike proteins [8], and vascular endothelial cells are damaged by spike proteins in the bloodstream ; this may damage the immune system organs such as the adrenal gland.
Additionally, antibody-dependent enhancement may occur, wherein infection-enhancing antibodies attenuate the effect of neutralizing antibodies in preventing infection [10].
The original antigenic sin [11], that is, the residual immune memory of the Wuhan-type vaccine may prevent the vaccine from being sufficiently effective against variant strains. These mechanisms may also be involved in the exacerbation of COVID-19.
In conclusion, COVID-19 vaccination is a major risk factor for infections in critically ill patients.
She suffered all of the "common" side effects of the vaccine but hoped these would last approximately 12 to 18 hours, the inquest heard. But two weeks later she was "screaming in pain" with the "worst headache" she had ever experienced.
Despite this, a CT scan was reported as "normal". Three days after her admission, Kasey was administered a dose of platelets and her inquest heard that she began to rapidly deteriorate.
She suffered from fits and was "not responding to seizure control", the inquest heard. She was then incubated and put on a ventilator where doctors performed another CT scan, now revealing the blood clot.
Doctors decided that brain surgery would not be in Kasey's best interest and could result in "significant brain damage". After Kasey's condition did not improve the following day, sedative drugs were withdrawn so doctors could accurately assess her neurological state.
She was found to be "brain stem dead" so mechanical ventilation was withdrawn and she died later that day.
Nothing to see here, nope. Completely sayf and effektiv.
A former taekwondo champion who had his leg amputated weeks after receiving the covid vaccination has vowed to battle back.
He was forced to return to England in April last year and was beginning to rebuild his life in his hometown of Stamford when he fell ill. Dave’s flu-like symptoms started within hours of having the AstaZeneca vaccination against Covid-19 on March 4. His symptoms got progressively worse over the following month. His foot started to swell and he was rushed to Addenbrooke’s Hospital for treatment on April 10. His left leg was later amputated below the knee.
A 26-year-old graduate died from a rare complication of the AstraZeneca Covid vaccine after being given out-of-date information about the risk of blood clots, an inquest has heard.
Jack Hurn, who was originally from Devon but was living in Redditch, Worcestershire, died in June last year, less than two weeks after receiving the jab in the West Midlands.
A week-long inquest at Birmingham Coroner’s Court was told a GP informed Mr Hurn the risk of blood clots on the brain for his age group was one in 250,000, when the latest NHS guidance estimated it to be one in 50,000.
The inquest heard the Coventry University automotive design graduate opted to go ahead with his first dose of the AstraZeneca vaccine on May 29 2021, after being told the Revival Fires vaccination hub in Dudley had no stock of the Pfizer jab.
Mr Hurn - whose girlfriend Alex Jones also received the AstraZeneca vaccine at the clinic - became unwell eight days after the jab and died in hospital on June 11 despite emergency surgery.
Ms Brown added: "Jack was not given all of the information to make an informed choice. "In particular the risk of complications for his age group was understated." A spokesman for NHS England in the Midlands said: "Our sincere condolences are with Jack Hurn’s family and friends for the tragic loss that they have suffered, and we recognise how difficult it will have been to relive the events this week.
Medics haven’t confirmed the cause of the infection, but Dave fears it was linked to the vaccine.