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Science is only valid in this debate if it comes from obscurity & as you know that is the best science.
originally posted by: AaarghZombies
originally posted by: puzzled2
So gene therapy is
Definition
Where DNA is inserted artificially into a cell to treat a genetic disease.
Use in clinical context
The principle behind gene therapy is that protein production can be altered. This can be in cells that do not produce a particular protein when they should, or they produce an altered version of the protein that does not function correctly.
Gene therapy delivers a functioning copy of a gene to cells. This is usually done using a non-infectious virus to deliver the gene to the target cells. It does not integrate the new DNA into the chromosomes, but exists as free-floating DNA in the nucleus where it can be transcribed into mRNA. Once transcribed, the mRNA is processed in the same way as mRNA transcribed from chromosomal DNA.
Seems like add a bit of DNA get the New DNA to create mRNA that is processed in the same manner as natural.
So if you skip the first part and just generate the mRNA artificially -
how is the body going to react any differently than if you added a piece of DNA to create the 1st mRNA.
IF both processes are designed to produce mRNA to cause a change within receiving cells what difference does it make who sent the message?
The mRNA in the vax acts outside of the nucleolus, so it cannot insert it's DNA into you.
You'd need to significantly change the composition of the vax in order for it to do what you suggest.
Are you a virologist ?
originally posted by: thethinkingman
"COVID-19 mRNA Vaccine BNT162b2 encodes a mutant viral spike (S) protein of SARS-CoV-2, with two point mutations inserted to lock S in an antigenically preferred prefusion conformation (P2 S). It is formulated as an RNA-lipid nanoparticle of nucleosidemodified mRNA containing N1-methylpseudouridine instead of uridine. Encapsulation into lipid nanoparticles enables transfection of the mRNA into host cells after intramuscular injection. During mixing of the RNA and the dissolved lipids, the lipids form the nanoparticles encapsulating the RNA. After injection, the lipid nanoparticles are taken up by the cells, and the RNA is released into the cytosol. In the cytosol, the RNA is translated into the encoded viral protein. The viral spike (S) protein antigen induces an adaptive immune response through neutralising antibodies. Furthermore, as the expressed spike (S) protein is being degraded intracellularly, the resulting peptides can be presented at the cell surface, triggering a specific T cell-mediated immune response with activity against the virus and infected cells."
This is explaining how the nanoparticles enter ANY cell they encounter, it also speaks of....T CELL immune reaction.
"ALC-0315 is the functional cationic lipid component of the drug product. When incorporated in lipid nanoparticles, it helps regulate the endosomal release of the RNA. During drug product manufacturing, introduction of an aqueous RNA solution to an ethanolic lipid mixture containing ALC-0315 at a specific pH leads to an electrostatic interaction between the negatively charged RNA backbone and the positively charged cationic lipid. This electrostatic interaction leads to encapsulation of RNA drug substance resulting with particle formation. Once the lipid nanoparticle is taken up by the cell, the low pH of the endosome renders the LNP fusogenic and allows the release of the RNA into the cytosol.
The primary function of the PEGylated lipid ALC-0159 is to form a protective hydrophilic layer that sterically stabilises the LNP which contributes to storage stability and reduces nonspecific binding to proteins. As higher PEG content can reduce cellular uptake and interaction with the endosomal membrane, PEG content is controlled."
linkypop
....put 2 and 2 together....foreign material enters cell....starts hijacking your protein manufacturing aparatus ......this triggers an immune response to stop that....that response is cd8 killer t cells DESTROYING those cells.... if these are capable of going all around the body....then your the immune attacks could be so random depending on where this stuff goes in each persons body.
originally posted by: andy06shake
a reply to: thethinkingman
And how does the above constitute the Oxford AstraZeneca vaccine being gene therapy given that the vaccine functions by using "a harmless virus that has been altered to have the SARS-CoV-2 protein" on its surface alone?
Where are the deliberate changes made to the DNA given that the vaccine never enters the nucleus of the cell or interacts with the person's DNA?
Gene therapies permanently change a cells DNA, are you claiming that's what the viral vector AstraZeneca vaccine or any other COVID-19 mRNA vaccine does?
President of Bayer’s Pharmaceuticals Division, Stefan Olerich, admitted at the World Health Summit in November 2021 that the COVID mRNA vaccines are a form of gene therapy.
Because the vaccine introduces new genetic material into cells for a short period of time to induce antibodies, it is a gene therapy as defined by ASGCT
originally posted by: thethinkingman
I wonder how many people would say yes please if you said "im going to be injecting 50 billion genetically modified chimpanzee adeno viruses into you".
I suspect not very many and they'd probably think you're insane. Its intriguing why this was not clearly relayed to people multiple times to make very sure they understand thats what the astra zeneca injection contains.
Further context shows that he was instead speaking about how the acceptance of a biotech innovation like mRNA COVID-19 vaccines was an example of how cell and gene therapies, another biotech innovation, could be received by the public.
VERDICT
False. In this clip, Bayer executive Stefan Oelrich did not “admit” that mRNA COVID-19 vaccines are “in fact” gene therapy. He was highlighting the public’s acceptance of a technological innovation like mRNA COVID-19 vaccines as an example of how people could potentially also accept the company’s gene and cell therapies. While mRNA vaccines do use genetic material, they are not designed to change the recipient’s genetic makeup and thus they are distinct from gene therapy.
vaccine, suspension of weakened, killed, or fragmented microorganisms or toxins or other biological preparation, such as those consisting of antibodies, lymphocytes, or messenger RNA (mRNA), that is administered primarily to prevent disease. A vaccine can confer active immunity against a specific harmful agent by stimulating the immune system to attack the agent. Once stimulated by a vaccine, the antibody-producing cells, called B cells (or B lymphocytes), remain sensitized and ready to respond to the agent should it ever gain entry to the body.
gene therapy, also called gene transfer therapy, introduction of a normal gene into an individual’s genome in order to repair a mutation that causes a genetic disease. When a normal gene is inserted into the nucleus of a mutant cell, the gene most likely will integrate into a chromosomal site different from the defective allele; although that may repair the mutation, a new mutation may result if the normal gene integrates into another functional gene. If the normal gene replaces the mutant allele, there is a chance that the transformed cells will proliferate and produce enough normal gene product for the entire body to be restored to the undiseased phenotype.
originally posted by: BaseHead
Science is only valid in this debate if it comes from obscurity & as you know that is the best science.
originally posted by: AaarghZombies
originally posted by: puzzled2
So gene therapy is
Definition
Where DNA is inserted artificially into a cell to treat a genetic disease.
Use in clinical context
The principle behind gene therapy is that protein production can be altered. This can be in cells that do not produce a particular protein when they should, or they produce an altered version of the protein that does not function correctly.
Gene therapy delivers a functioning copy of a gene to cells. This is usually done using a non-infectious virus to deliver the gene to the target cells. It does not integrate the new DNA into the chromosomes, but exists as free-floating DNA in the nucleus where it can be transcribed into mRNA. Once transcribed, the mRNA is processed in the same way as mRNA transcribed from chromosomal DNA.
Seems like add a bit of DNA get the New DNA to create mRNA that is processed in the same manner as natural.
So if you skip the first part and just generate the mRNA artificially -
how is the body going to react any differently than if you added a piece of DNA to create the 1st mRNA.
IF both processes are designed to produce mRNA to cause a change within receiving cells what difference does it make who sent the message?
The mRNA in the vax acts outside of the nucleolus, so it cannot insert it's DNA into you.
You'd need to significantly change the composition of the vax in order for it to do what you suggest.
originally posted by: v1rtu0s0
originally posted by: thethinkingman
I wonder how many people would say yes please if you said "im going to be injecting 50 billion genetically modified chimpanzee adeno viruses into you".
I suspect not very many and they'd probably think you're insane. Its intriguing why this was not clearly relayed to people multiple times to make very sure they understand thats what the astra zeneca injection contains.
Thats why they have to lie about every aspect of the scamdemic.
originally posted by: andy06shake
a reply to: fernalley
Bull #.
Further context shows that he was instead speaking about how the acceptance of a biotech innovation like mRNA COVID-19 vaccines was an example of how cell and gene therapies, another biotech innovation, could be received by the public.
VERDICT
False. In this clip, Bayer executive Stefan Oelrich did not “admit” that mRNA COVID-19 vaccines are “in fact” gene therapy. He was highlighting the public’s acceptance of a technological innovation like mRNA COVID-19 vaccines as an example of how people could potentially also accept the company’s gene and cell therapies. While mRNA vaccines do use genetic material, they are not designed to change the recipient’s genetic makeup and thus they are distinct from gene therapy.
www.reuters.com...
Edit: Also your second link dont work and prompts "400 Bad Request".
Because the vaccine introduces new genetic material into cells for a short period of time to induce antibodies, it is a gene therapy as defined by ASGCT.
Bayer executive Stefan Oelrich did not “admit” that mRNA COVID-19 vaccines are “in fact” gene therapy. He was highlighting the public’s acceptance of a technological innovation like mRNA COVID-19 vaccines as an example of how people could potentially also accept the company’s gene and cell therapies. While mRNA vaccines do use genetic material, they are not designed to change the recipient’s genetic makeup and thus they are distinct from gene therapy.
originally posted by: AaarghZombies
originally posted by: BaseHead
Science is only valid in this debate if it comes from obscurity & as you know that is the best science.
originally posted by: AaarghZombies
originally posted by: puzzled2
So gene therapy is
Definition
Where DNA is inserted artificially into a cell to treat a genetic disease.
Use in clinical context
The principle behind gene therapy is that protein production can be altered. This can be in cells that do not produce a particular protein when they should, or they produce an altered version of the protein that does not function correctly.
Gene therapy delivers a functioning copy of a gene to cells. This is usually done using a non-infectious virus to deliver the gene to the target cells. It does not integrate the new DNA into the chromosomes, but exists as free-floating DNA in the nucleus where it can be transcribed into mRNA. Once transcribed, the mRNA is processed in the same way as mRNA transcribed from chromosomal DNA.
Seems like add a bit of DNA get the New DNA to create mRNA that is processed in the same manner as natural.
So if you skip the first part and just generate the mRNA artificially -
how is the body going to react any differently than if you added a piece of DNA to create the 1st mRNA.
IF both processes are designed to produce mRNA to cause a change within receiving cells what difference does it make who sent the message?
The mRNA in the vax acts outside of the nucleolus, so it cannot insert it's DNA into you.
You'd need to significantly change the composition of the vax in order for it to do what you suggest.
It's a demonstratable fact of science that mRNA can leave the nucleolus of a cell, but not enter it.
Here's the "for dummies" version: Link
Seriously, didn't anybody on this forum do biology in college?
originally posted by: Ravenwatcher
Got news yesterday that a friends grandson who's been California vaxed and boosted is in the ICU this morning getting his lungs drained they say he's got some rare pneumonia he's 2 years old .
Pneumonia can affect people of any age, but it's more common, and can be more serious, in certain groups of people, such as the very young or the elderly.
People in these groups are more likely to need hospital treatment if they develop pneumonia.
originally posted by: AaarghZombies
originally posted by: BaseHead
Science is only valid in this debate if it comes from obscurity & as you know that is the best science.
originally posted by: AaarghZombies
originally posted by: puzzled2
So gene therapy is
Definition
Where DNA is inserted artificially into a cell to treat a genetic disease.
Use in clinical context
The principle behind gene therapy is that protein production can be altered. This can be in cells that do not produce a particular protein when they should, or they produce an altered version of the protein that does not function correctly.
Gene therapy delivers a functioning copy of a gene to cells. This is usually done using a non-infectious virus to deliver the gene to the target cells. It does not integrate the new DNA into the chromosomes, but exists as free-floating DNA in the nucleus where it can be transcribed into mRNA. Once transcribed, the mRNA is processed in the same way as mRNA transcribed from chromosomal DNA.
Seems like add a bit of DNA get the New DNA to create mRNA that is processed in the same manner as natural.
So if you skip the first part and just generate the mRNA artificially -
how is the body going to react any differently than if you added a piece of DNA to create the 1st mRNA.
IF both processes are designed to produce mRNA to cause a change within receiving cells what difference does it make who sent the message?
The mRNA in the vax acts outside of the nucleolus, so it cannot insert it's DNA into you.
You'd need to significantly change the composition of the vax in order for it to do what you suggest.
It's a demonstratable fact of science that mRNA can leave the nucleolus of a cell, but not enter it.
Here's the "for dummies" version: Link
Seriously, didn't anybody on this forum do biology in college?