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SARS‐CoV‐2 causes acute, highly lethal pneumonia with clinical symptoms similar to those reported for SARS‐CoV and MERS‐CoV.2, 11 Imaging examination revealed that most patients with fever, dry cough, and dyspnea showed bilateral ground‐glass opacities on chest computerized tomography scans.12 However, different from SARS‐CoV, SARS‐CoV‐2‐infected patients rarely showed prominent upper respiratory tract signs and symptoms, indicating that the target cells of SARS‐CoV‐2 may be located in the lower airway.2 Based upon the first‐hand evidence from Wuhan local hospitals,2, 10, 12 the common symptoms of COVID‐19 were fever (83%‐99%) and dry cough (59.4%‐82%) at the onset of illness. However, the most characteristic symptom of patients is respiratory distress (~55%). Among the patients with dyspnea, more than half needed intensive care. About 46% to 65% of the patients in the intensive care worsened in a short period of time and died due to respiratory failure. Among the 36 cases in the intensive care reported by Wang et al,10 11.1% received high‐flow oxygen therapy, 41.7% received noninvasive ventilation, and 47.2% received invasive ventilation. These data suggest that most (about 89%) of the patients in need of intensive care could not breathe spontaneously. It is now known that CoVs are not always confined to the respiratory tract and that they may also invade the CNS inducing neurological diseases. Such neuroinvasive propensity of CoVs has been documented almost for all the βCoVs, including SARS‐CoV,1 MERS‐CoV,13 HCoV‐229E,14 HCoV‐OC43,15 mouse hepatitis virus,16 and porcine hemagglutinating encephalomyelitis coronavirus (HEV).9, 17-19 With respect to the high similarity between SARS‐CoV and SARS‐CoV2, it remains to know whether the potential neuroinvasion of SARS‐CoV‐2 plays a role in the acute respiratory failure of patients with COVID‐19.
THE NEUROINVASIVE POTENTIAL OF SARS‐CoV‐2 It is believed that the tissue distributions of host receptors are generally consistent with the tropisms of viruses.20-22 The entry of SARS‐CoV into human host cells is mediated mainly by a cellular receptor angiotensin‐converting enzyme 2 (ACE2), which is expressed in human airway epithelia, lung parenchyma, vascular endothelia, kidney cells, and small intestine cells.23-25 Different from SARS‐CoV, MERS‐CoV enters human host cells mainly via dipeptidyl peptidase 4 (DPP4), which is present in the lower respiratory tract, kidney, small intestine, liver, and the cells of the immune system.26, 27 However, the presence of ACE2 or DPP4 solely is not sufficient to make host cells susceptible to infection. For example, some ACE2‐expressing endothelial cells and human intestinal cell lines failed to be infected by SARS‐CoV,28, 29 while some cells without a detectable expression level of ACE2, such as hepatocytes could also be infected by SARS‐CoV.20 Likewise, the infection of SARS‐CoV or MERS‐CoV was also reported in the CNS, where the expression level of ACE230 or DDP430 is very low under normal conditions.
originally posted by: elitegamer23
originally posted by: burdman30ott6
a reply to: elitegamer23
No, I just won't lay my freedoms down because in this country's 250 years millions have been sent to fight and die to secure those freedoms... we have 80,000 positive cases and 1200 deaths and that's enough to be expected to lay those freedoms down over? Bullsnip! The price was already paid for and we're several million away from even beginning to see the current value reach that price.
The only freedom I have currently lost is the freedom to walk into McDonald’s to order a cheeseburger .
Joel Baines, a virologist and professor of pathobiological sciences at LSU School of Veterinary Medicine, recalls attending a Mardi Gras party and being the only one there who seemed apprehensive about the large social gathering. He said testing is critical to finding asymptomatic spreaders: those who have been infected, and are unknowingly transmitting the virus to others, despite being perfectly healthy. "They're really the danger for the rest of the population," Baines said. "It's not their fault, but they're shedding virus to people who are more vulnerable."
There is one major difference between 1918 Philadelphia and 2020 New Orleans. This year, there was no indication coronavirus was spreading in New Orleans during Carnival. The first case in Louisiana wasn't reported publicly until March 9 — 13 days after Mardi Gras. During the monthlong celebration, no one in Louisiana was aware the virus was probably spreading quiety, other than a few people whose radars were tuned to viral diseases.
originally posted by: Bicent
a reply to: burdman30ott6
Bro you should be in the mud pit with this. You know it too, MR mod. 😛🥩
Following today’s roll back of doom and gloom COVID-19 death tolls from Epidemiologist Neil Ferguson, who now says he was wrong, UK health officials downgraded the threat level to just around the flu. The downgrade is causing controversy all over the Internet as many citizens in the United States question restrictive, sometimes draconian, shutdowns. Over 3 million of your fellow Americans sit in their homes tonight, jobless, depressed, and feeling massive anxiety. Wrap your heads around that. Here is MSNBC’s Joe Scarborough, just 7 hours ago, questioning Trump’s decision making using the now-debunked science.
originally posted by: burdman30ott6
originally posted by: Bicent
a reply to: burdman30ott6
Bro you should be in the mud pit with this. You know it too, MR mod. 😛🥩
Wow, we've reached the point where embracing Constitutional Rights is mudslinging. Mass hysteria, indeed.
originally posted by: sine.nomine
originally posted by: burdman30ott6
originally posted by: Bicent
a reply to: burdman30ott6
Bro you should be in the mud pit with this. You know it too, MR mod. 😛🥩
Wow, we've reached the point where embracing Constitutional Rights is mudslinging. Mass hysteria, indeed.
No, we've reached a thread for virus updates. You're in the wrong thread for discussing constitutional rights.
originally posted by: Brick17
a reply to: DankyDSmythe
I have not heard that.
What I can say is that preparations for things becoming much more serious are underway. By that I mean full on support - military aid to the civil authority. Op Trumpeter for example would see service personnel on the streets in support of the civil authority in many different ways.
There are other ops now ongoing and others on standby. Tanker drivers, distribution hubs, transport, medical, civil order, admin, planning, stores, help in planning, logistics, identifying areas for use, the list goes on. I know that in some cases those leaving the military, discharges, have been stopped/delayed, postings/assignments stopped/delayed, personnel being recalled. Another forces mate of mine has seen movement of medical equipment headed down south.
Life goes on at my location as I have previously described. As we have a critical defence role and asset we are not involved directly with MACA. There are some who are involved having to go but not many. Our priority task is to support the critical defence asset.
I have never seen anything like this. The military, we are always trained to plan for the worst case scenario. There are always plans for everything. The big difference this time is that we are actually preparing and implementing, that's no small thing. That makes me believe TBTB know #. No idea how many of us will go down with the virus or what our causality rate will be.
I don't know what's happening NHS wise. I'm only hearing what the average joe public is. They are obviously struggling but to what extent I don't know. I'd expect it to vary from area to area. NHS is recalling as many health professionals as they can. There is no doubt in my mind that they are under massive strain.
On a personal level I am a wee bit concerned that I may have to leave the family at some point in the near future during this time. I think there will have to be some sort of enforced lockdown after observing how so many people have acted so far.
Like I have always said, I'm optimistic but I really don't know which direction this will all take or how bad it will truly become. I'm of the opinion that there are some areas that will be hit badly. The army isn't setting up a field hospital in a hard standing location, the excel cen in London for no reason. That place is huge. There are others locations being chosen and not just as hostipals, body storage, hubs of all kinds that I have heard and know of. Glad I'm in a rural area far from any city or town.
Look after each other and be kind. Respect to all those in our NHS.
originally posted by: all2human
a reply to: burdman30ott6
Be careful about loving those freedoms before life itself
originally posted by: burdman30ott6
originally posted by: elitegamer23
originally posted by: burdman30ott6
a reply to: elitegamer23
No, I just won't lay my freedoms down because in this country's 250 years millions have been sent to fight and die to secure those freedoms... we have 80,000 positive cases and 1200 deaths and that's enough to be expected to lay those freedoms down over? Bullsnip! The price was already paid for and we're several million away from even beginning to see the current value reach that price.
The only freedom I have currently lost is the freedom to walk into McDonald’s to order a cheeseburger .
Talk to the millions who have lost the freedom to provide for their families because governments have decided what businesses are essential and what ones aren't. Talk to the millions of Americans in places like Chicago where they have to "show cause" to leave their homes and can be fined for being out too long or for unapproved reasons. Talk to the millions of churchgoers who have been told by the government that they cannot visit their chosen houses of worship and congregate per their religious traditions. Freedoms are being crapped on across the USA right now.