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Confirmed COVID-19 was defined (per FDA guidance)4
as the presence of at least 1 of the following symptoms and a positive SARS-CoV-2 NAAT (determined by the central laboratory or at a local testing facility using an acceptable test) during, or within 4 days before or after, the symptomatic period:
fever; new or increased cough; new or increased shortness of breath; chills;
new or increased muscle pain; new loss of taste or smell; sore throat; diarrhea; vomiting.
Confirmed COVID-19 (according to the CDC-defined symptoms) was defined as above, adding the following to the list of symptoms:
fatigue; headache; nasal congestion or runny nose; nausea.5
Confirmed severe COVID-19 was defined (per FDA guidance)4 as confirmed COVID-19 and the presence of at least 1 of the following:
Clinical signs at rest indicative of severe systemic illness (RR ≥30 breaths per minute, HR ≥125 beats per minute, SpO2 ≤93% on room air at sea level, or PaO2/FiO2 < 300 mm Hg);
Respiratory failure (defined as needing high-flow oxygen, noninvasive ventilation, mechanical ventilation, or ECMO);
Evidence of shock (SBP less than 90 mm Hg, DBP less than 60 mm Hg, or requiring vasopressors);
Significant acute renal, hepatic, or neurologic dysfunction*;
Admission to an ICU;
Death.
Interim and Final Analyses
The assessment of efficacy against confirmed COVID-19 was event-driven. Initially, 4 interim analyses were planned to be performed by an unblinded statistical team supporting the data monitoring committee after accrual of 32, 62, 92, and 120 confirmed COVID-19 cases for the first primary endpoint, with the final analysis performed after accrual of at least 164 cases. For operational reasons, the first planned IA (after 32 cases) was not performed. Amendment 9 to the C4591001 protocol eliminated the planned interim analysis at 32 cases and provided for 3 interim analyses to be performed after accrual of at least 62, 92, and 120 cases for the first primary endpoint. At each of the IAs, vaccine efficacy with respect to the first primary efficacy endpoint was to be assessed. At the final analysis (at least 164 cases) vaccine efficacy with respect to all efficacy endpoints was to be assessed.
originally posted by: RelSciHistItSufi
a reply to: RelSciHistItSufi
FUTURE PROVES PAST? I was right to raise it - but the route to impacting Western gold balance sheets differs...
From my post on 28th:
cranky, worth considering the price the Russian central bank is offering for GOLD - per your "Gold Telegraph BREAKING NEWS":
5,000 Roubles per gram...
Exchange rate = 102 Roubles/US Dollar,
Therefore $49.02/gram... or $49,020/Kilogram bullion bar.
There are 31.103 grams per Troy Ounce = $1,524.7/Troy Ounce.
Think what that will do to bank balance sheets across Europe/U.S. - they will need to buy 21% more Gold to avoid being hit by Basel III - and going bankrupt!
UKWO1Phot reply
Cheapest on there is £1560 per Oz rather than $1524 as stated above.
£300 difference.
My reply
Yup, need to wait a while to let the price adjust, methinks!
The above all made the assumption that the Russian move would break Western banks by devaluing Gold - but it appears the tactic is actually to reduce western banks access to Gold by making people sell it to Russia?
From Silence Dogood MBA on Nate Burruano's telegram
This one chart describes the Modern Warfare. Although the physical War in Ukraine is happening, it's more of a charade of casualties than a proxy for "what happens next". Look there, not here. These charts are what actually move the needle and tell you what will be happening next.
www.reddit.com...
☕️✝️
So Russia is offering $114 more per ounce of Gold than the COMEX spot price! How do the banks re-stock their balance sheets if people want to sell it to Russia instead?
Could this be the 11.4 MARKER?
ETA - This only took 3 days from 28th to 31st!
The proposal for the extension was put forward by IMF staff to the Executive Board in a paper published on March 15, 2021
Bitcoin could reach a price of $1.3 million while gold may top $31,000 per ounce, if the assets become the sole reserve asset across the globe, respectively, according to a new report.
originally posted by: RelSciHistItSufi
Petemitchell, care to comment on whether this looks reasonable for a classification of covid positive in pfizer clinical trials?
From latest documents release: STN-125742_0_0-Section-2.7.3-Summary-of-Clinical-Efficacy.pdf
Confirmed COVID-19 was defined (per FDA guidance)4
as the presence of at least 1 of the following symptoms and a positive SARS-CoV-2 NAAT (determined by the central laboratory or at a local testing facility using an acceptable test) during, or within 4 days before or after, the symptomatic period:
fever; new or increased cough; new or increased shortness of breath; chills;
new or increased muscle pain; new loss of taste or smell; sore throat; diarrhea; vomiting.
Confirmed COVID-19 (according to the CDC-defined symptoms) was defined as above, adding the following to the list of symptoms:
fatigue; headache; nasal congestion or runny nose; nausea.5
Confirmed severe COVID-19 was defined (per FDA guidance)4 as confirmed COVID-19 and the presence of at least 1 of the following:
Clinical signs at rest indicative of severe systemic illness (RR ≥30 breaths per minute, HR ≥125 beats per minute, SpO2 ≤93% on room air at sea level, or PaO2/FiO2 < 300 mm Hg);
Respiratory failure (defined as needing high-flow oxygen, noninvasive ventilation, mechanical ventilation, or ECMO);
Evidence of shock (SBP less than 90 mm Hg, DBP less than 60 mm Hg, or requiring vasopressors);
Significant acute renal, hepatic, or neurologic dysfunction*;
Admission to an ICU;
Death.
What differentiates this from normal cold or flu?
Is this reasonable?
Interim and Final Analyses
The assessment of efficacy against confirmed COVID-19 was event-driven. Initially, 4 interim analyses were planned to be performed by an unblinded statistical team supporting the data monitoring committee after accrual of 32, 62, 92, and 120 confirmed COVID-19 cases for the first primary endpoint, with the final analysis performed after accrual of at least 164 cases. For operational reasons, the first planned IA (after 32 cases) was not performed. Amendment 9 to the C4591001 protocol eliminated the planned interim analysis at 32 cases and provided for 3 interim analyses to be performed after accrual of at least 62, 92, and 120 cases for the first primary endpoint. At each of the IAs, vaccine efficacy with respect to the first primary efficacy endpoint was to be assessed. At the final analysis (at least 164 cases) vaccine efficacy with respect to all efficacy endpoints was to be assessed.
Pfizer April document release link
There’s a bug out there causing chaos…but the response has been suboptimal…intentionally
NEWS
The nickel in your coins is now worth more than 5 cents, but you can’t cash in
originally posted by: pheonix358
As yet I have not managed to find out who she was named after.
"Letter Classes", usually used for Destroyers and Submarines (though some TL5 light cruisers were also named this way): The class name is a letter of the alphabet; all ships in the class have names starting with this letter.
originally posted by: F2d5thCavv2
a reply to: FlyingFox
Man! Wonder if I can score a pad on that boat. Life on the water ...
Cheers
originally posted by: RelSciHistItSufi
a reply to: SMOKINGGUN2012
What the hell does Ukraine have to do with 11.3 marker? NOTHING....
If you can't be bothered to read then I can't be bothered to debate:
1. Would you believe this... there is a "humanitarian organization" literally called ukrainekc.org, set up in March 2022 (though DDG doesn't want to show the page!)
DENY IGNORANCE!
originally posted by: Justoneman
originally posted by: F2d5thCavv2
a reply to: FlyingFox
Man! Wonder if I can score a pad on that boat. Life on the water ...
Cheers
Careful what you wish for F2d5th. I have no inclination to find out bad things and my name on the list of invited guests.