Corona Virus Updates Part 6

A preprint from the MedRxIv server: Cholesterol and COVID19 lethality in elderly


From the abstract:

Here we show loading cells with cholesterol from blood serum using the cholesterol transport protein apolipoprotein E (apoE) enhances the endocytic entry of pseudotyped SARS-CoV-2. Super resolution imaging of the SARS-CoV-2 entry point with high cholesterol showed markedly increased apparent diameter (~10% to 100 nm) and almost twice the total number of viral entry points. The cholesterol concomitantly traffics angiotensinogen converting enzyme (ACE2) to the viral entry site where SARS-CoV-2 docks to properly exploit entry into the cell. Furthermore, we show cholesterol enhances binding of SARS-CoV-2 to the cell surface which increases association with the endocytic pathway. Decreasing cellular cholesterol has the opposite effect. Based on these findings and known loading of cholesterol into peripheral tissue cholesterol during aging and inflammation, we build a cholesterol dependent model for COVID19 lethality in elderly and the chronically ill.

TRANSLATION:

Study was done in the lab and not on living things. They're trying to figure out why Covid-19 is so deadly in certain groups. This initial study shows that if you have high cholesterol, the changes in your body include "widening" of the "gateways" that let the virus into the cells of your body.

Moral of the Story: If you've got high cholesterol, for pete's sake take your meds. Promptly. Particularly if you can't avoid groups of people (if you're a cashier, for instance, or someone who comes into contact with a lot of people.)

NEWSPAPER STORY: Statistics at the National Health Institute for Great Britain reported on the most dangerous jobs for men in the Covid-19 outbreak

The usual suspects are there - taxi driver, for instance, and bus conductor. The real surprise, however, is that payroll clerks are in the top 10. Car mechanics are also high... not good because we have to take two cars in to be repaired.

I'm ... gonna lysol the car down really well afterwards.

Numbers from around the world are taken from Worldometers for May 11th.

Spain - Pop: 44.6 M
268,143 Positive tests…….. or 1 out of 174 Spaniards
9.97% Deaths of positive tested
National Deaths (26,744) 1 per 1,745

Italy - Pop: 60.4 M
219,814 Positive tests….. or 1 out of 275 Italians
13.98 % Deaths of positive tested
National Deaths (30,739) 1 per 1,968

UK – Pop: 66.6 M
223,060 Positive tests….. or 1 out of 299 UKers
14.37 % Deaths of positive tested
National Deaths (32,065) 1 per 2,079

France – Pop: 67.0 M
176,970 Positive tests….. or 1 out of 379 French
14.90 % Deaths of positive tested
National Deaths (26,380) 1 per 2,539

Sweden – Pop: 10.2 M
26,670 Positive tests….. or 1 out of 384 Swedes
12.20 % Deaths of positive tested
National Deaths (3,256) 1 per 3,142

Denmark – Pop: 5.8 M
10,513 Positive tests….. or 1 out of 552 Danes
5.06 % Deaths of positive tested
National Deaths (533) 1 per 10,882

US - Pop: 330 M
1,370.850 Positive tests.... or 1 out of 241 Americans
5.89 % Deaths of positive tested
National Deaths 1 per 4,081

US death rates (2017):
1. Heart Disease …………….…………647,457 annual or 1,773 daily average
2. Cancer ……………………..……….….599,108 annual or 1,641 daily average
3. Accidents (unintentional injuries): 169,936 annual or 465 daily average
6. Alzheimer’s disease:…….……….121,404 annual or 332 daily average
7. Diabetes:………………………………….83,564 annual or 228 daily average

COVID-19 ………………………………………. 80,869 (72 Day) or 1123 daily average


*** SURPASSED *****

8. Influenza and Pneumonia …………55,562 annual or 152 daily average
9. Nephritis, nephrotic syndrome, and nephrosis:..50,633 annual or 138 daily average
10. Intentional self-harm (suicide):..47,173 annual or 129 daily average
X. Auto accidents ………………….………37,461 annual or 102 daily average
X. H1N1 2009 ESTIMATED (8,868 – 18,638) for 1 year or 24 – 50 daily average

a reply to: InterplanetaryHobo

Are you going to elaborate or are you just posting Death ?

here is the real number
www.cdc.gov...

The overall Mortality rate of Covid-19 is has been substantialy lowered since adding the actual number of cases into the equation , meaning this virus has been here for much longer than previously thought.

More evidence those who smoke are less likely to end up in hospital by 5 times, although if they do end up in hospital, they are more likely to die.

MORE evidence emerges that smokers are protected from coronavirus: Italian study finds them FIVE TIMES less likely to end up in hospital (but almost twice as likely to die if they do)

www.dailymail.co.uk...

esearchers have uncovered more evidence that smokers could be protected from the deadly coronavirus. Fewer than five per cent of 441 COVID-19 patients who needed to be admitted to an Italian hospital were smokers. The scientists described it as a 'very low' number, given that a quarter of the general population are known to be hooked on cigarettes. It suggests smokers are less likely to catch the disease - a theory that has emerged over the past few weeks from several global studies. But once smokers are in hospital, they may be more likely to see their disease rapidly progress and lead to death, according to some evidence. The new study found half of infected smokers died - compared to 35 per cent of the rest of the patients. Experts are struggling to knock down mounting evidence that suggests an apparent protective effect from cigarettes, which has been described as 'weird'.

a reply to: CrazeeWorld777

covid and its dilemmas

today in a daily health education program in italy a doctor suggested to go a bit out in the sun between 11 and 3 pm strictly without sunscreen

originally posted by: asabuvsobelow
a reply to: InterplanetaryHobo

Are you going to elaborate or are you just posting Death ?

here is the real number
www.cdc.gov...

The overall Mortality rate of Covid-19 is has been substantialy lowered since adding the actual number of cases into the equation , meaning this virus has been here for much longer than previously thought.

The numbers are a match, actually.

The CDC document you linked has a couple of caveats, including "this is for data up to May 9" (not the 11th, which is today.)

NOTE: Number of deaths reported in this table are the total number of deaths received and coded as of the date of analysis and do not represent all deaths that occurred in that period.

*Data during this period are incomplete because of the lag in time between when the death occurred and when the death certificate is completed, submitted to NCHS and processed for reporting purposes. This delay can range from 1 week to 8 weeks or more, depending on the jurisdiction, age, and cause of death.

It also codes Covid-19 deaths in TWO different places in the table ... so you have to add the number in the first column to the number in the 5th column.

The footnotes at the bottom say specifically what's in each column, as you can see from the footnote (headers) I've copied for both Column 1 and Column 5.

1Deaths with confirmed or presumed COVID-19, coded to ICD–10 code U07.1.

....
5 Deaths with confirmed or presumed COVID-19, pneumonia, or influenza, coded to ICD–10 codes U07.1 or J09-18.9.

oops possible new CHEAP treatment - about to snuffed out if Trump mentions it.

I want to ask something.
Are there scientific data that this virus damages organs permanently? If yes, does it damage even those who recovered lightly?
Thanks..

A good deal of science and information of what happens when all types of labs work together.

Corona virus - 2 is 10x the size of normal size there are over 29 proteins effected in human body over 60 medicines out there being looked at. HCQ is be discontinued because there are to good at bonding to heart cells -- hence don't give it to heart patients.

Long video lots of good info

montana.maps.arcgis.com... one new case in jefferson county but so far we seem to be still dodging the worst of it in montana and i think were set to enter phase two soonish

a reply to: CrazeeWorld777

Would that be because they have to stop smoking in the Hospital?

originally posted by: deccal
I want to ask something.
Are there scientific data that this virus damages organs permanently? If yes, does it damage even those who recovered lightly?
Thanks..

Yes, multiple sources, including lung damage.

I don't think we know enough about (and it hasn't been around for decades) it to assess how ill they have to be to risk organ problems.

Some news stories here:
www.washingtonpost.com... 0-7db1-11ea-a3ee-13e1ae0a3571_story.html

news.yahoo.com...

damage to lungs (from a clinic website)

www.latimes.com...

Pubmed research paper saying amount of damage depends on how ill you are

originally posted by: anonentity
a reply to: CrazeeWorld777

Would that be because they have to stop smoking in the Hospital?

No, that's not it. Their lungs would have been damaged from smoking, and few months isn't enough to totally undo lung damage caused by cigarettes.

Numbers Update for Europe, and Elsewhere (A bit late, and still no BNO) :







www.worldometers.info...

a reply to: Byrd

That's strange given that half the lung transplants use smokers lungs , and they all have the survival rate the same as non smokers. www.independent.co.uk...

originally posted by: anonentity
a reply to: Byrd

That's strange given that half the lung transplants use smokers lungs , and they all have the survival rate the same as non smokers. www.independent.co.uk...

It is. I saw some papers on it but didn't review them for here. I'll go back and see what they were.

Just one of many weird things about this virus!