a reply to:
lostgirl
They skip over some important issues for some reason. Not sure of their motivation? They’re falling into the same trap as the media now and our
government moron friends.
Viral infection is the target with these vaccines, a virus infects a cell. So logically the primary defense pathway for a virus will be a defense that
targets the infected cells, not something that targets something outside a cell like an antibody. This is cell mediated immunity, induced by Th1
inflammatory response or reaction to that infection. This is stimulated by receptors that recognize foreign genes in the cell, release an antiviral
signaling protocol through interferon, and then activate interferon stimulated genes to fight the infection.
Our target is more easily seen after the virus infects us, it’s like a sliding scale that we target with vaccines used for viruses. We target the
replicase complex, we could hit the virus as it’s initially reproducing in the cell. We target the spike, it’s more likely we recognize it as
it’s shedding and spreading to other cells. This is because it takes time for cell based defenses to recognize that cells are infected. Antibody
responses are much later.
It goes like this: Person inhales virus, virus binds to cell with ACE2 receptor, virus releases genes as pH drops when it enters the cell, genes move
to ribosomes for generating viral proteins, proteins hijack cell processes and begin copying viral genes, cell identifies foreign genes and attempts
to stop all protein production, virus attempts to bypass halt in protein production, genes are copied and thousands of virions are released and
secreted from the cell until the cell is exhausted of resources.
Our bodies (and the virus) can target and interfere with almost every step of the pathway. The most important with a viral infection is interferon.
This occurs when the cell recognizes foreign genes. If this is missed and interferon is delayed, the patient progresses to the nasty stages of COVID.
So with a virus that can suppress this pathway pretty well, vaccination may not matter.
With our immune response to viral infection it goes like this: Cells identify viral infection and change external receptors to the innate immune
system and natural killer cells screen and touch every cell they encounter. Once cells fail the handshake check, NK cells tell them to self destruct,
antigen presenting cells take up the pieces, antigen is taken to the lymph nodes and presented to T-cells, or presented to T cells present in that
tissue that do not circulate, cytotoxic T cells are trained to go after the infected cells, helper T cells are trained to induce antibody and
regulatory responses to fill in immunity gaps from previous infection and vaccination, IgM is released early in infection to combat virus, IgG and IgA
are released later in infection, up to days or weeks, to clean up and give additional targets.
IgM is a big wheel like structure that has 10 antigen binding sites and clumps stuff together, IgG has two and is the classic Y shape. It can easily
cross barriers and release into many areas. IgA is like two IgG hooked together in structure so it has 4 binding sites and can move through mucous.
But with a virus, it’s most important use is following the virion into a cell and binding it there to stop it from releasing genes as pH decreases.
Antibodies don’t just sit there and wait, it’s too energy intensive.
We have general ones sure but initial defenses are barrier based, cell based, and intrinsic or occurring within a cell. Those people died of sepsis,
most likely caused by a barrier and intrinsic failure leading to a delayed interferon response, although with some of their issues I would expect
cell based responses to be hypo or hyper vigilant which could also cause issues.
The vaccine is secondary and it most likely would not have made a difference. Plus, we need more data and specifics about these patients but heart
failure as cause of death is appropriate for a virus that caused respiratory failure. Cells infected or presenting as infected are not always
destroyed, if they were, every time we got a lung infection or an arm vaccine, we would have gaping wounds pretty quickly.
Secretory IgA is that specific antibody that would be generated by B cells. Serum IgA is that nonspecific type that would be present to help prevent
infection in something like tears of the eye or the GI tract. They’re being tricky with words to play on those not educated in the field. Not sure
of why but it’s weird.
The vaccine issues seem to be a complement issue or some type of undiagnosed HLA abnormality that causes issues with targeting and determining self
from foreign, having a preexisting autoimmune condition does seems to make it worse and they are becoming more common in the developed world,
they’re just undiagnosed.