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originally posted by: FlyingFox
“The hope is that we will achieve something that will have way, way better protection particularly against infections, because the protection against the hospitalizations and the severe disease — it is reasonable right now with the current vaccines as long as you are having let’s say the third dose,” Bourla said.
The Hill
Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host, then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak.
Omicron is Not Normal
Everything suggests this variant was leaked from a laboratory engaged in gain-of-function research.
As el gato malo and others have indicated, evidence is strong that Omicron circulates preferentially in the vaccinated. In all likelihood, it is the result of gain-of-function research, in which SARS-2 was passaged repeatedly through convalescent or vaccinated plasma, in the hopes of helping the virus evade acquired immunity. The purpose of this research would be to anticipate future immune-escape variants that vaccines might target.
Omicron’s ancestors may have spent a significant amount of time adapting to mouse cells, before re-entering human hosts. Omicron appears selected to replicate primarily in the bronchial tract. Deeper in the human lung, it functions far less efficiently than Delta or the first strains from Wuhan. This is probably why it causes mostly mild illness, and it is reminiscent of techniques used to make live attenuated influenza vaccines safer for use in humans.
You're awesome! Wow.
originally posted by: crankyoldman
Looks like Saget might reach Baldwin levels of Connections. Worth noting of course that "Full House" shows up in the drops, as does one of the Olsen's with Chandler. The oddest of places, the most curious of symbols, the strangest connections - the reality busting apart at the seams it seems.
originally posted by: FlyingFox
a reply to: crankyoldman
B) We have always been at war with Eastasia...?
The president of the European Parliament David Sassoli has died, his office announced early on Tuesday morning.
He passed away after a "serious complication" related to his immune system.