posted on Nov, 17 2013 @ 01:51 AM
I'm wondering if you guys have seen any reference to the dosage of ascorbic acid being affected by the bodyweight of the individual? Julie do you
know? In many nutrients, this is a fairly critical issue. I can't find anything on this. I have a high bodyweight, even in bone, so this may
compensate compared to ordinary mortals. ;-)
I am about to begin a brief experiment with high dose liposomal C. My process appears to work pretty well and I expect that I am getting a good
encapsulation. This is allegedly estimated at ~79% absorption, but to be conservative I estimate 70%.
I was unable to find specific refs to the approximate absorption % of the different forms (oral AA, oral buffered-AA, liposomal, intravenous) of C and
would appreciate if anyone has specific refs as I'm going off fuzzy memory here. I searched for the IV rates and got paralysis by analysis at the
amount of data none of which just said "about X %."
I had once read that intestinal absorption of oral AA was around 10-16%; that buffered intestinal absorption was 18-23%, but I am not sure about that,
or whether that 'translates' after processed by the body as truly that much. I had once read that IV absorption was actually only 30-odd% but its
ability to be a chronic ongoing dose was the bigger deal with it, however in the research refs I find, they refer to 'blood levels' as up to
70-100-fold higher (maximums) than oral dosage; then again we aren't really concerned with what the blood has (note: plasma concentrates may be
higher than whole-blood) but what the tissues have, and this seems to vary with the person and tissues and may be a completely separately thing, so...
maybe it's just impossible to measure.
I have not been able to find research on lecithin dosages over 30g/day in normal weight humans and I'm pretty sure that was soy lecithin from unknown
sources. I currently use sunflower lecithin. And since the only studies I can find on C are on intravenous, and I don't know how to compare that
decently to liposomal -- especially since drip-IV and large-dose swallows are yet another variable -- I'm not sure on that one either.
I'm intending to ingest approximately 90g lecithin and 30g ascorbic (together in homemade liposomal form) daily (that is 2 batches), as many days as
possible for a maximum of 8 weeks. I am rather poor at consistency I'm afraid so I'm going to make a real effort but I may miss some days. I will
taper off (within 7 days) at 8 weeks if I have not already stopped the experiment for other reasons. I am re-starting taking it after having not
ingested any of it for a few weeks, so any previous amounts should be out of my system.
I intend to simply record how I feel a couple times a day in a few categories, and any symptoms good or bad which may relate. This is a medium term
test to see what effect both lecithin and ascorbic have on me. Both are separate variables which are known to be good but could, in high dose, be
questionable. Obviously this is only an N=1 casual layman experiment, so there is no control, and placebo effect likelihood is high.
Although, as a caveat to the placebo note, I am actually not expecting any "noticeable" effect from having a dose higher than my previous dosages,
except possibly it may be slightly more diuretic, and possibly have some more noticeable skin benefit. (If it seems too acidic I may take up some
yogurt in a big way.) My hope is that it may have some NOT 'noticeable' effects which may still be "good under the hood," so to speak, for liver,
kidneys, bladder, gastrointestinal tract, nerve sheaths and all cell membranes. However I am not sure that effects in those areas would be consciously
perceivable to me even if it did do some good, aside from the same degree of positive effects I have already previously experienced from lower
dosages.
I will ask my best friend to post here if it should kill me, so I can at least serve as a warning to others. ;-) I don't expect it to.
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low estimate 70% absorption x 30g (daily in separate doses) = 21g via liposomes
9g remaining, baking soda buffer on it to spare some sourness, so estimate ~20% absorption (higher due to buffer) = 1.8g
so that is 22.8g total assumed absorption
with 6.2 assumed either venting into the digestive system outlets or used promptly to handle junk in my system.
This may seriously mess up my digestion. I cannot handle more than 2g orally even of buffered forms without digestive issues in pills. We'll see.
I'll put up with it if so, as long as I can anyway.
I was attempting to figure out what this would equate to in other forms of C.
At 16% oral absorption of (non-buffered) AA, it would take 142.5g intake to equal this.
Since I don't know what the IV tissue-absorption rate is, I can't compare it to that.
Part of my goal was to come up with a number that would be similar to IV doses of ~100g+/daily.
My hope is to take this in 3 doses of 1 cup each.
I have previously taken my homemade liposomal C in daily doses ranging from 1/2 cup (about 5g AA/15g Lec) to 1.5 cups (15g AA/45g Lec) daily. I have
not taken any but the smaller dose for even as much as 4 days consecutively. Aside from the first 10 days or so (on small dose) I've been very
sporadic, with long periods off, and almost no periods with more than 3 days in a row without 1 to 1++ days missed.
During this I will also be intaking a complete spectrum of (in many cases high-dose) vitamins, minerals, and some other enzymes and herbs. And while
my food intake is normally very healthy, this is happening during the holiday season, a vacation, a friend visiting, so my food is actually likely to
be pretty crappy through a lot of this. Well, good thing I'll be taking plenty of C, lol.
Will put high-volume process in next post (went over char count).