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Intermezzo® (zolpidem tartrate) is indicated for use as needed for the treatment of insomnia when a middle-of-the-night awakening is followed by difficulty returning to sleep.
Co-administration with Intermezzo and other CNS depressants increases the risk of CNS depression. Intermezzo should not be taken with alcohol. The use of Intermezzo with other sedative-hypnotics (including other zolpidem products) at bedtime or the middle of the night is not recommended. The risk of next-day driving impairment (and psychomotor impairment) is increased if Intermezzo is taken with less than 4 hours of bedtime remaining; if higher than recommended dose is taken; if co-administered with other CNS depressants; or co-administered with other drugs that increase the blood levels of zolpidem. A small negative effect on SDLP (standard deviation of lateral position, a measure of driving impairment) may remain in some patients 4 hours after taking Intermezzo, such that a potential negative effect on driving cannot be completely excluded. The failure of insomnia to remit after 7 to 10 days of treatment may indicate the presence of a primary psychiatric and/or medical illness that should be evaluated. Cases of angioedema involving the tongue, glottis, or larynx have been reported in patients after taking the first or subsequent doses of zolpidem. Some patients have had additional symptoms such as dyspnea, throat closing, or nausea and vomiting that suggest anaphylaxis. Some patients have required medical therapy in the emergency department. Angioedema, and additional symptoms suggesting anaphylaxis, may occur in patients taking zolpidem and may be fatal. Patients who develop angioedema or anaphylaxis should not be rechallenged.
Abnormal thinking and behavior changes have been reported in patients treated with a sedative-hypnotic including zolpidem. Complex behaviors, including driving or eating while not fully awake, with amnesia for the event, as well as visual and auditory hallucinations and abnormal behaviors such as decreased inhibition, bizarre behavior, agitation, and depersonalization may occur. Although behaviors such as “sleep-driving” have occurred with zolpidem alone at therapeutic doses, the co-administration of zolpidem with alcohol and other CNS depressants increases the risk of such behaviors, as does the use of zolpidem at doses exceeding the maximum recommended dose. Discontinuation of Intermezzo should be strongly considered for patients reporting a “sleep-driving” episode. In primarily depressed patients, worsening of depression, including suicidal thoughts and actions (including completed suicides) have been reported with the use of sedative-hypnotics. Intentional overdosage is more common in this group of patients; therefore, protective measures may be required and prescribe the least amount of Intermezzo that is feasible.
Because persons with a history of addiction to or abuse of drugs or alcohol are at increased risk for misuse, abuse, and addiction of zolpidem, they should be monitored carefully when receiving Intermezzo. Zolpidem tartrate is a Schedule IV controlled substance. Post-marketing reports of abuse, dependence, and withdrawal resulting from use of oral zolpidem tartrate have been received. Zolpidem has produced withdrawal signs and symptoms following a rapid dose decrease or abrupt discontinuation. The most commonly observed adverse reactions (>1%) were headache (Intermezzo 3%, placebo 1%), nausea (1% for both patient groups), and fatigue (Intermezzo 1%, placebo 0%). Please read the Full Prescribing Information. To report SUSPECTED ADVERSE REACTIONS, contact Purdue Pharma L.P. at 1-888-726-7535 or FDA at 1-800-FDA-1088 or www.fda.gov/Safety/MedWatch. Intended for healthcare professionals of the United States of America only. ©2013 Purdue Pharma L.P., Stamford, CT 06901-3431
Originally posted by daskakik
Originally posted by 2manyquestions
Guns don't kill people. People kill people.
If they don't kill people then logically they also don't save people.
There is a difference between killing someone and not being able to save them. Sure there are cases where a doctor may be the cause of death but you can't just label every death that occurs "death by doctor".
According to the FBI Uniform Crime Report, between 2006 and 2010 47,856 people were murdered in the U.S. by firearms, more than twice as many as were killed by all other means combined.
Originally posted by daskakik
reply to post by 2manyquestions
Someone arrives at a hospital having a heart attack after a decades of an unhealthy lifestyle and the doctors are not able to save him and you want to place the blame on the doctors? Maybe the Health Ranger is OK with that but I am not.
The deaths from drunk driving are probably not included because of the lack of intent to kill on the part of the driver.
Originally posted by 2manyquestions
We see things differently. Irresponsibility, carelessness, disrespect and stupidity is what kills. Who cares if Jane didn't mean to murder anyone on her way home from the bar? She got drunk, she got behind the wheel and didn't give it a second thought that she might kill an innocent family on the way. To me that's the same as taking a gun and firing a few rounds into the air, potentially killing one or more people with a stray bullet. To me that's the same as playing with a loaded gun and accidentally shooting your friend or classmate. It's the same as having a lack of respect for the person you're about to shoot dead out of a jealous or vengeful rage.
As for doctors,.... we're not talking about those who do everything in their power to do everything right, we're talking about those who have lack of knowledge or don't pay enough attention to their patients to notice they're either misdiagnosing them, leaving a dirty sponge inside them, or prescribing a dangerous combination of drugs without giving it a second thought. That's part of being careless, stupid and maybe even disrespectful.
Originally posted by 2manyquestions
Originally posted by purplemer
Doctors kill 2,450% more Americans than all gun-related deaths combined
Yes but Doctors save a more lifes than guns...
Guns can and do save lives as well. That's why you see cops carrying guns.
Originally posted by pillock
Quoting naturalnews , believing what they are saying and posting it here on ATS is a double face palm.
We know that naturalnews is a bad site to be quoting .
Originally posted by ParasuvO
reply to post by CX
I laugh at the people who are beyond paranoid, and those are the ones complaining about this source.
Originally posted by LesMisanthrope
reply to post by winterkill
The Dr's are trying to save lives, not intending to kill. There's a really, really big difference between Dr's and guns. I didn't think I needed to point point out the absurdities here, but apparently I do.
Dr's aren't weapons. Guns aren't humans trying to save lives.
Oh and here's what violent means for future reference:
violent |ˈvī(ə)lənt|
adjective
using or involving physical force intended to hurt, damage, or kill someone or something: a violent confrontation with riot police.
• (esp. of an emotion or unpleasant or destructive natural force) very strong or powerful: violent dislike | the violent eruption killed 1,700 people.
• (of a color) vivid.
• Law involving an unlawful exercise or exhibition of force.