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originally posted by: GetHyped
a reply to: MotherMayEye
I have no idea how you have concluded that. I am saying: The dosage makes the poison.
So I ask again: At what dose is aluminium a neurotoxin?
originally posted by: Krazysh0t
a reply to: MotherMayEye
I'm not saying anything of the sort. Where are we seeing a problem of people with dangerous levels of these substances being given the marginal amount to kill them? Don't invent nonsensical hypothetical situations around what I said.
Aluminum is established as a neurotoxin, although the basis for its toxicity is unknown. It recently has been shown to alter the function of the blood-brain barrier (BBB), which regulates exchanges between the central nervous system (CNS) and peripheral circulation. The BBB owes its unique properties to the integrity of the cell membranes that comprise it. Aluminum affects some of the membrane-like functions of the BBB. It increases the rate of transmembrane diffusion and selectively changes saturable transport systems without disrupting the integrity of the membranes or altering CNS hemodynamics. Such alterations in the access to the brain of nutrients, hormones, toxins, and drugs could be the basis of CNS dysfunction. Aluminum is capable of altering membrane function at the BBB; many of its effects on the CNS as well as peripheral tissues can be explained by its actions as a membrane toxin.
Abstract Once biologically available aluminum bypasses gastrointestinal and blood–brain barriers, this environmentally-abundant neurotoxin has an exceedingly high affinity for the large pyramidal neurons of the human brain hippocampus. This same anatomical region of the brain is also targeted by the earliest evidence of Alzheimer's disease (AD) neuropathology. The mechanism for the selective targeting and transport of aluminum into the hippocampus of the human brain is not well understood. In an effort to improve our understanding of a pathological aluminum entry system into the brain, this study examined the aluminum content of 8 arteries that supply blood to the hippocampus, including the aorta and several cerebral arteries. In contrast to age-matched controls, in AD patients we found a gradient of increasing aluminum concentration from the aorta to the posterior cerebral artery that supplies blood to the hippocampus. Primary cultures of human brain endothelial cells were found to have an extremely high affinity for aluminum when compared to other types of brain cells. Together, these results suggest for the first time that endothelial cells that line the cerebral vasculature may have biochemical attributes conducive to binding and targeting aluminum to selective anatomical regions of the brain, such as the hippocampus, with potential downstream pro-inflammatory and pathogenic consequences.
"I shoulder that the CDC has put the research ten years behind. Because the CDC has not been transparent, we’ve missed ten years of research, because the CDC is so paralyzed right now by anything related to autism. They’re not doing what they should be doing. They are afraid to look for things that might be associated."
originally posted by: NightSkyeB4Dawn
Even if there was an agreed amount of aluminum that is deemed safe, the fact that our continued exposure to aluminum over such a protracted period of time is accumulative, deems any additional amount to be risky.
Why industry propaganda and political interference cannot disguise the inevitable role played by human exposure to aluminum in neurodegenerative diseases, including Alzheimer's disease
originally posted by: MotherMayEye
a reply to: GetHyped
This is what the FDA says is safe:
"The FDA study found that the maximum amount of aluminum an infant could be exposed to over the first year of life would be 4.225 milligrams (mg), based on the recommended schedule of vaccines. Federal Regulations for biological products (including vaccines) limit the amount of aluminum in the recommended individual dose of biological products, including vaccines, to not more than 0.85-1.25 mg. For example, the amount of aluminum in the hepatitis B vaccine given at birth is 0.25 mg."
I am saying that for kids who are exposed to significant levels of aluminum elsewhere -- perhaps those aren't safe levels.
As I understand it, aluminum toxicity is generally suspected when overt symptoms present. I can't imagine that happens at the same exact level in every person.
originally posted by: GetHyped
a reply to: MotherMayEye
So when you say "aluminium is a neurotoxin", you can't actually back up the claim as to what dose. Instead, you make vague speculations unsupported by evidence, even though you claim "Science agrees with that". That's very dishonest of you.
originally posted by: GetHyped
originally posted by: MotherMayEye
a reply to: GetHyped
This is what the FDA says is safe:
"The FDA study found that the maximum amount of aluminum an infant could be exposed to over the first year of life would be 4.225 milligrams (mg), based on the recommended schedule of vaccines. Federal Regulations for biological products (including vaccines) limit the amount of aluminum in the recommended individual dose of biological products, including vaccines, to not more than 0.85-1.25 mg. For example, the amount of aluminum in the hepatitis B vaccine given at birth is 0.25 mg."
I am saying that for kids who are exposed to significant levels of aluminum elsewhere -- perhaps those aren't safe levels.
As I understand it, aluminum toxicity is generally suspected when overt symptoms present. I can't imagine that happens at the same exact level in every person.
More baseless speculation. Science isn't about wild guesses.
For someone that claims to not be anti-vaccine, you sure do work hard to spread misinformation and not bother to inform yourself of the science behind them.
originally posted by: MotherMayEye
No, I claimed that science agrees that aluminum is a neurotoxin and that is true.
originally posted by: GetHyped
a reply to: MotherMayEye
No one claims that everyone has the same physiology, but to say that we can't come up with safe doses within reasonable margins of error is just plain stupid.
What's the safe dose of water?
"Everyone is different! We can't come up with a safe dose! It's all dangerous!!!".
originally posted by: MotherMayEye
...
I think the point is that protocol was not followed because the conclusions were controversial. This is one example that we know about. Are there others we don't know about?
Thu Jun 4, 2015 10:06am EDT
By Brendan Pierson
Two former Merck & Co Inc scientists accusing the drugmaker of falsifying tests of its exclusive mumps vaccine said in a court filing on Monday that Merck is refusing to respond to questions about the efficacy of the vaccine.
Attorneys at Constantine Cannon, who represent the scientists, asked U.S. Magistrate Judge Lynne Sitarski of the Eastern District of Pennsylvania to compel Merck to respond to their discovery request, which asks the company to give the efficacy of the vaccine as a percentage.
...
Central Figure in CDC Vaccine Cover-Up Absconds With $2M
Posted: 05/11/2010 5:12 am EDT
A central figure behind the Center for Disease Control's (CDC) claims disputing the link between vaccines and autism and other neurological disorders has disappeared after officials discovered massive fraud involving the theft of millions in taxpayer dollars. Danish police are investigating Dr. Poul Thorsen, who has vanished along with almost $2 million that he had supposedly spent on research.
Thorsen was a leading member of a Danish research group that wrote several key studies supporting CDC's claims that the MMR vaccine and mercury-laden vaccines were safe for children. Thorsen's 2003 Danish study reported a 20-fold increase in autism in Denmark after that country banned mercury based preservatives in its vaccines. His study concluded that mercury could therefore not be the culprit behind the autism epidemic.
His study has long been criticized as fraudulent since it failed to disclose that the increase was an artifact of new mandates requiring, for the first time, that autism cases be reported on the national registry. This new law and the opening of a clinic dedicated to autism treatment in Copenhagen accounted for the sudden rise in reported cases rather than, as Thorsen seemed to suggest, the removal of mercury from vaccines. Despite this obvious chicanery, CDC has long touted the study as the principal proof that mercury-laced vaccines are safe for infants and young children. Mainstream media, particularly the New York Times, has relied on this study as the basis for its public assurances that it is safe to inject young children with mercury -- a potent neurotoxin -- at concentrations hundreds of times over the U.S. safety limits.
...