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originally posted by: ElectricUniverse
Lol, you simply don't want to accept anything presented to you that differs with your own views...
originally posted by: ElectricUniverse
You want to ignore what doctors, specialists and researchers have to say and what their research found. You want to claim "they are all pseudo-scientists" and not experts"... All based on the limited research you posted which obviously is there to side with big pharma, and to try to dismiss what many others have found.
originally posted by: ElectricUniverse
You continuously keep ignoring even with the fact that not all batches of vaccines use the same ingredients, or the same adjuvants.
originally posted by: ElectricUniverse
You fail to see that not all children get the same amount of vaccines. There are children, or adults who are given for example single doses of flu vaccines that don't have ethyl-mercury in them, while others receive multiple-dose flu vaccines which do still contain Thimerosal/ethyl-mercury... So of course there will be studies that will not find a link while others will...
originally posted by: ElectricUniverse
Then there is the "propaganda", even coming from you. Heck, you have claimed so far that heavy metals like aluminum, and substances like ethyl-mercury cannot be toxic to the human body which is nothing more than a lie.
You claim the human body can easily get rid of these substances despite evidence that shows the contrary...
originally posted by: ElectricUniverse
You want to claim this is not happening simply because not everyone is affected the same way, be it because not everyone gets the same accumulation of these substances since manufacturers of vaccines frequently change the ingredients of their vaccines; or because not everyone get as many vaccines as other children and adults get...
originally posted by: haviahabia
All these liberals are afraid of vaccines because the Huffington post tells them things like that.
...
originally posted by: Pardon?
Nope. Wrong again.
Disingenuous because of what I originally stated. Massive doses in high frequency of administration.
Comparing apples with spaceships.
Thimerosal does not accumulate, it is metabolised and excreted.
Curr Probl Pediatr Adolesc Health Care. Author manuscript; available in PMC May 17, 2011.
Published in final edited form as:
Curr Probl Pediatr Adolesc Health Care. Sep 2010; 40(8): 186–215.
doi: 10.1016/j.cppeds.2010.07.002
...
Mercury Exposure and Children’s Health
Stephan Bose-O’Reilly, MD, MPH,a Kathleen M. McCarty, ScD, MPH,b Nadine Steckling, BSc,a and Beate Lettmeier, PhDa
Author information ► Copyright and License information ►
The publisher's final edited version of this article is available at Curr Probl Pediatr Adolesc Health Care
...
Abstract.
Acute or chronic mercury exposure can cause adverse effects during any period of development. Mercury is a highly toxic element; there is no known safe level of exposure. Ideally, neither children nor adults should have any mercury in their bodies because it provides no physiological benefit. Prenatal and postnatal mercury exposures occur frequently in many different ways. Pediatricians, nurses, and other health care providers should understand the scope of mercury exposures and health problems among children and be prepared to handle mercury exposures in medical practice. Prevention is the key to reducing mercury poisoning. Mercury exists in different chemical forms: elemental (or metallic), inorganic, and organic (methylmercury and ethyl mercury). Mercury exposure can cause acute and chronic intoxication at low levels of exposure. Mercury is neuro-, nephro-, and immunotoxic. The development of the child in utero and early in life is at particular risk. Mercury is ubiquitous and persistent. Mercury is a global pollutant, bio-accumulating, mainly through the aquatic food chain, resulting in a serious health hazard for children. This article provides an extensive review of mercury exposure and children’s health.
...
originally posted by: Pardon?
You need to read properly.
...
"Effectively no mercury in vaccines" do you need me to explain that again and why thimerasol isn't mercury, again?
Thimerosal and Animal Brains: New Data for Assessing Human Ethylmercury Risk
Julia R. Barrett
Additional article information
Since the 1930s, vaccines have contained thimerosal, a mercury-based preservative that breaks down to ethylmercury and thiosalicylate in the body. By some calculations, children given the usual schedule of vaccines containing thimerosal receive ethylmercury in doses exceeding the U.S. Environmental Protection Agency’s guidelines for methylmercury, a known neurotoxicant. Because of the lack of pharmacokinetic and toxicity data for ethylmercury, methylmercury has been used as a reference for ethylmercury toxicity based on the assumption that the two compounds share similar toxicokinetic profiles. However, a new animal study shows that methylmercury is an inadequate reference for ethylmercury due to significant differences in tissue distribution, clearance rates, and ratios of organic to inorganic mercury in the brain [EHP 113:1015–1021].
During their first two years, children in the United States may receive more than 20 routine vaccinations. The rise in childhood autism has sparked concerns that thimerosal-derived ethylmercury may be at least partly to blame for some of these cases—concerns that are largely driven by awareness of methylmercury’s neurotoxicity. Beginning in 1999 thimerosal-free versions of routine vaccines for children under age 6 started becoming available. However, as of winter 2005, the flu vaccine still contained thimerosal, and the preservative continues to be used in vaccines in other countries.
In the current study, researchers assigned 41 newborn monkeys to one of three exposure groups. Seventeen of the monkeys were injected with vaccines spiked with thimerosal for a total mercury dose of 20 micrograms per kilogram (μg/kg) at ages 0, 7, 14, and 21 days, mimicking the typical schedule of vaccines for human infants. At the same ages, another 17 monkeys received 20 μg/kg methylmercury by stomach tube to mimic typical methylmercury exposure. A third group of 7 monkeys served as unexposed controls.
...
Brain concentrations of total mercury were approximately 3–4 times lower in the thimerosal group than in the methylmercury group, and total mercury cleared more rapidly in the thimerosal group (with a half-life of 24.2 days versus 59.5 days). However, the proportion of inorganic mercury in the brain was much higher in the thimerosal group (21–86% of total mercury) compared to the methylmercury group (6–10%). Brain concentrations of inorganic mercury were approximately twice as high in the thimerosal group compared to the methylmercury group. Inorganic mercury remains in the brain much longer than organic mercury, with an estimated half-life of more than a year. It’s not currently known whether inorganic mercury presents any risk to the developing brain.
...
Neurochem Res. Feb 2012; 37(2): 436–447.
Published online Oct 21, 2011. doi: 10.1007/s11064-011-0630-z
PMCID: PMC3264864
Administration of Thimerosal to Infant Rats Increases Overflow of Glutamate and Aspartate in the Prefrontal Cortex: Protective Role of Dehydroepiandrosterone Sulfate
Michalina Duszczyk-Budhathoki,1 Mieszko Olczak,1,3 Malgorzata Lehner,2 and Maria Dorota Majewskacorresponding author1,4
Abstract.
Thimerosal, a mercury-containing vaccine preservative, is a suspected factor in the etiology of neurodevelopmental disorders. We previously showed that its administration to infant rats causes behavioral, neurochemical and neuropathological abnormalities similar to those present in autism. Here we examined, using microdialysis, the effect of thimerosal on extracellular levels of neuroactive amino acids in the rat prefrontal cortex (PFC). Thimerosal administration (4 injections, i.m., 240 μg Hg/kg on postnatal days 7, 9, 11, 15) induced lasting changes in amino acid overflow: an increase of glutamate and aspartate accompanied by a decrease of glycine and alanine; measured 10–14 weeks after the injections. Four injections of thimerosal at a dose of 12.5 μg Hg/kg did not alter glutamate and aspartate concentrations at microdialysis time (but based on thimerosal pharmacokinetics, could have been effective soon after its injection). Application of thimerosal to the PFC in perfusion fluid evoked a rapid increase of glutamate overflow. Coadministration of the neurosteroid, dehydroepiandrosterone sulfate (DHEAS; 80 mg/kg; i.p.) prevented the thimerosal effect on glutamate and aspartate; the steroid alone had no influence on these amino acids. Coapplication of DHEAS with thimerosal in perfusion fluid also blocked the acute action of thimerosal on glutamate. In contrast, DHEAS alone reduced overflow of glycine and alanine, somewhat potentiating the thimerosal effect on these amino acids. Since excessive accumulation of extracellular glutamate is linked with excitotoxicity, our data imply that neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEAS may partially protect against mercurials-induced neurotoxicity.
...
originally posted by: ElectricUniverse
The whole point of this thread has been to make people aware that they have options in vaccines that do not have as many adjuvants such as aluminum, or thimerosal, but people have to ask for these vaccines which have less, or no adjuvants or other substances like ethylmercury.
Pardon, has been, alongside some other members, dismissing what the evidence from many doctors, biochemists, and other specialists and research has to say.
According to pardon, the body can naturally excrete any accumulation of toxins by itself, and this is patently a lie. If this claim was true then there wouldn't be cases of toxicity due to accumulation of toxic substances, which do include adjuvants and substances like ethylmercury.
originally posted by: Pardon?
Nope. Wrong again.
Disingenuous because of what I originally stated. Massive doses in high frequency of administration.
Comparing apples with spaceships.
Thimerosal does not accumulate, it is metabolised and excreted.
First of all, it doesn't have to be a "massive dose"... Not to mention that you are lying yet again. The mercury in thimerosal can, and does accumulate in the body, and eventually can end up in the nervous system and the brain.
Curr Probl Pediatr Adolesc Health Care. Author manuscript; available in PMC May 17, 2011.
Published in final edited form as:
Curr Probl Pediatr Adolesc Health Care. Sep 2010; 40(8): 186–215.
doi: 10.1016/j.cppeds.2010.07.002
...
Mercury Exposure and Children’s Health
Stephan Bose-O’Reilly, MD, MPH,a Kathleen M. McCarty, ScD, MPH,b Nadine Steckling, BSc,a and Beate Lettmeier, PhDa
Author information ► Copyright and License information ►
The publisher's final edited version of this article is available at Curr Probl Pediatr Adolesc Health Care
...
Abstract.
Acute or chronic mercury exposure can cause adverse effects during any period of development. Mercury is a highly toxic element; there is no known safe level of exposure. Ideally, neither children nor adults should have any mercury in their bodies because it provides no physiological benefit. Prenatal and postnatal mercury exposures occur frequently in many different ways. Pediatricians, nurses, and other health care providers should understand the scope of mercury exposures and health problems among children and be prepared to handle mercury exposures in medical practice. Prevention is the key to reducing mercury poisoning. Mercury exists in different chemical forms: elemental (or metallic), inorganic, and organic (methylmercury and ethyl mercury). Mercury exposure can cause acute and chronic intoxication at low levels of exposure. Mercury is neuro-, nephro-, and immunotoxic. The development of the child in utero and early in life is at particular risk. Mercury is ubiquitous and persistent. Mercury is a global pollutant, bio-accumulating, mainly through the aquatic food chain, resulting in a serious health hazard for children. This article provides an extensive review of mercury exposure and children’s health.
...
www.ncbi.nlm.nih.gov...
originally posted by: ElectricUniverse
I also posted how one of the doctors from the CDC was caught ADMITTING that the CDC had omitted data from their research on vaccines which show some sections of the population are more susceptible to adverse effects/toxicity from the adjuvants and substances like ethylmercury. But this doctor only admitted to this to a biochemist without knowing he was being recorded. Was it wrong that he was being recorded without his knowledge?... Sure, it is unfortunate that it was done that way, but the truth is this doctor would not have admitted this if he knew he was being recorded.
Neurochem Res. Feb 2012; 37(2): 436–447.
Published online Oct 21, 2011. doi: 10.1007/s11064-011-0630-z
PMCID: PMC3264864
Administration of Thimerosal to Infant Rats Increases Overflow of Glutamate and Aspartate in the Prefrontal Cortex: Protective Role of Dehydroepiandrosterone Sulfate
Michalina Duszczyk-Budhathoki,1 Mieszko Olczak,1,3 Malgorzata Lehner,2 and Maria Dorota Majewskacorresponding author1,4
Abstract.
Thimerosal, a mercury-containing vaccine preservative, is a suspected factor in the etiology of neurodevelopmental disorders. We previously showed that its administration to infant rats causes behavioral, neurochemical and neuropathological abnormalities similar to those present in autism. Here we examined, using microdialysis, the effect of thimerosal on extracellular levels of neuroactive amino acids in the rat prefrontal cortex (PFC). Thimerosal administration (4 injections, i.m., 240 μg Hg/kg on postnatal days 7, 9, 11, 15) induced lasting changes in amino acid overflow: an increase of glutamate and aspartate accompanied by a decrease of glycine and alanine; measured 10–14 weeks after the injections. Four injections of thimerosal at a dose of 12.5 μg Hg/kg did not alter glutamate and aspartate concentrations at microdialysis time (but based on thimerosal pharmacokinetics, could have been effective soon after its injection). Application of thimerosal to the PFC in perfusion fluid evoked a rapid increase of glutamate overflow. Coadministration of the neurosteroid, dehydroepiandrosterone sulfate (DHEAS; 80 mg/kg; i.p.) prevented the thimerosal effect on glutamate and aspartate; the steroid alone had no influence on these amino acids. Coapplication of DHEAS with thimerosal in perfusion fluid also blocked the acute action of thimerosal on glutamate. In contrast, DHEAS alone reduced overflow of glycine and alanine, somewhat potentiating the thimerosal effect on these amino acids. Since excessive accumulation of extracellular glutamate is linked with excitotoxicity, our data imply that neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEAS may partially protect against mercurials-induced neurotoxicity.
...
www.ncbi.nlm.nih.gov...
There is a lot of evidence showing that despite the lies from some people, substances like ethylmercury and aluminum adjuvants are known toxic substances to the human body which induce among other side effects oxidative stress, and inflammation, including in the brain.
Yet we have people like Pardon, trying to claim that "this is not true and the body by itself easily gets rids of any excess accumulation of these substances"?...
Really pardon?... If that was true then there would not be ANY case of toxicity at all from heavy metals or an excess of accumulated substances that can cause toxicity...
originally posted by: ElectricUniverse
Anyway, despite the "denials" by some people, there is more and more evidence that is linking autism and other neurological disorders and other health problems to vaccines.
I believe this topic is very important, more so for parents, and anyone who plans on being a parent.
As long as I can I will continue to update this thread with more research that proves that vaccines are not as safe as people are led to believe.
© 2008 Science Publications
Corresponding Author: Matthew P. Anderson, Departments of Neurology and Pathology,
Harvard Medical School/Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine,
Room 846, 77 Avenue Louis Pasteur, Boston, MA 02115 USA, Tel: 6176670853
167
Bridging from Cells to Cognition in Autism Pathophysiology: Biological
Pathways to Defective Brain Function and Plasticity
1Matthew P. Anderson, 2Brian S. Hooker and 3Martha R. Herbert
1Departments of Neurology and Pathology, Harvard Medical School/Beth Israel Deaconess Medical
Center, Harvard Institutes of Medicine, Room 846, 77 Avenue Louis Pasteur, Boston, MA 02115 USA
2High Throughput Biology Team, Fundamental Science Directorate, Pacific Northwest National
Laboratory, 902 Battelle Blvd., Richland, WA 99354 USA
3Pediatric Neurology/Center for Morphometric Analysis, Massachusetts General Hospital/Harvard
Medical School, 149 13th St., Room 6012, Charlestown, MA 02129 USA
and
Center for Child and Adolescent Development, Cambridge Health Alliance/Harvard Medical School,
101 Station Landing, Room 2105, Medford, MA 02155 USA
Abstract: We review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative stressors persist beyond early development (with potential further exacerbations), producing ongoing functional consequences. In organs with a high metabolic demand such as the central nervous system, the continued use of mitochondria with damaged DNA and impaired metabolic enzyme function may generate additional ROS which will cause persistent activation of the innate immune system leading to more ROS production. Such a mechanism would self-sustain and possibly progressively worsen. The mitochondrial dysfunction and altered redox signal transduction pathways found in autism would conspire to activate both astroglia and microglia. These activated cells can then initiate a broad-spectrum proinflammatory gene response. Beyond the direct effects of ROS on neuronal function, receptors on neurons that bind the inflammatory mediators may serve to inhibit neuronal signaling to protect them from excitotoxic damage during various pathologic insults (e.g., infection). In autism, over-zealous neuroinflammatory responses could not only influence neural developmental processes, but may more significantly impair neural signaling involved in cognition in an ongoing fashion. This model makes specific predictions in patients and experimental animal models and suggests a number of targets sites of intervention. Our model of potentially reversible pathophysiological mechanisms in autism motivates our hope that effective therapies may soon appear on the horizon.
...
thescipub.com...
ISSN 1553-3468
© 2008 Science Publications
Corresponding Author: J. Jay Gargus, MD, PhD. Prof., University of California, Irvine, School of Medicine, Department of
Physiology & Biophysics and Department of Pediatrics, Section of Human Genetics, 328 Sprague
Hall, 839 Medical Sciences Ct., Irvine, CA 92697-4034
198
Mitochondrial Energy-Deficient Endophenotype in Autism
1J. Jay Gargus and 2Faiqa Imtiaz
1Department of Physiology and Biophysics and
Department of Pediatrics, Section of Human Genetics, School of Medicine
University of California, Irvine
2Arabian Diagnostics Laboratory, King Faisal Specialist Hospital and Research Centre
P.O Box 3354, MBC 98-16, Riyadh 11211, Saudi Arabia
Abstract: While evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be involved in the etiology of this multifactorial disorder.
Furthermore, recent studies have pointed to a subset of autism associated with the biochemical endophenotype of mitochondrial energy deficiency, identified as a subtle impairment in fat and carbohydrate oxidation. This phenotype is similar, but more subtle than those seen in classic mitochondrial defects. In some cases the beginnings of the genetic underpinnings of these mitochondrial defects are emerging, such as mild mitochondrial dysfunction and secondary carnitine deficiency observed in the subset of autistic patients with an inverted duplication of chromosome 15q11-q13. In addition, rare cases of familial autism associated with sudden infant death syndrome (SIDS) or associated with abnormalities in cellular calcium homeostasis, such as malignant hyperthermia or cardiac arrhythmia, are beginning to emerge. Such special cases suggest that the pathophysiology of autism may comprise pathways that are directly or indirectly involved in mitochondrial energy production and to further probe this connection three new avenues seem worthy of exploration: 1) metabolomic clinical studies provoking controlled aerobic exercise stress to expand the biochemical phenotype, 2) high-throughput expression arrays to directly survey activity of the genes underlying these biochemical pathways and 3) model systems, either based upon neuronal stem cells or model genetic organisms, to discover novel genetic and environmental inputs into these pathways.
Key words: Carnitine, oxidative stress, 15q, SIDS, calcium, valproate, serotonin
...
thescipub.com...
Remember those other studies I showed all mentioning that metals in vaccines can cause oxidative stress, and inflammation causing neurological disorders? Metals such as aluminum which is added as an adjuvant to vaccines? Or Thimerosal which is formed 50% of mercury in weight?
originally posted by: Pardon?
A lot of anti-vaxxers use that study without understanding what it means or how the methodology makes the study irrelevant to vaccinations.
Do YOU know why it's irrelevant?
(I've told you before but here's another hint....look at the amount of mercury per kilo and look at how often it's administered).
...
The articles included in their review were any prospective (planned before data collection) or retrospective (planned after data collection) cohort and case-control (pairing study participants with and without a specific variable for comparison) studies. They excluded studies that used the US Vaccine Adverse Events Reporting System as their population because, as the authors note, there is a limitation of:
...
...
high risk of bias including unverified reports, underreporting, inconsistent data quality, absence of an unvaccinated control group and many reports being filed in connection with litigation.
There’s good reason for that exclusion–this is, after all, a database that has included reports that vaccines turned people into superheroes.
...
Vaccine Adverse Event Reporting System (VAERS)
On this Page
Reporting Vaccine Adverse Events
National Surveillance Data for Vaccine Adverse Events
Vaccines are developed with the highest standards of safety. However, as with any medical procedure, vaccination has some risks. Individuals react differently to vaccines, and there is no way to predict how individuals will react to a particular vaccine.
The National Childhood Vaccine Injury Act (NCVIA) requires health care providers to report adverse events (possible side effects) that occur following vaccination, so the Food and Drug Administration (FDA)External Web Site Icon and Centers for Disease Control and Prevention (CDC) established the Vaccine Adverse Events Reporting System (VAERS)External Web Site Icon in 1990. VAERS is a national passive reporting system that accepts reports from the public on adverse events associated with vaccines licensed in the United States. VAERS data are monitored to–
Detect new, unusual, or rare vaccine adverse events
Monitor increases in known adverse events
Identify potential patient risk factors for particular types of adverse events
Identify vaccine lots with increased numbers or types of reported adverse events
Assess the safety of newly licensed vaccines
Approximately 30,000 VAERS reports are filed annually, with 10-15% classified as serious (resulting in permanent disability, hospitalization, life-threatening illnesses or death). Anyone can file a VAERS report, including health care providers, manufacturers, and vaccine recipients or their parents or guardians. The VAERS form requests the following information
The type of vaccine received
The timing of the vaccination
The onset of the adverse event
Current illnesses or medication
Past history of adverse events following vaccination
Demographic information about the recipient
VAERS forms can be completed online, or you can complete a paper form and mail or fax it to VAERS.
...
Like other spontaneous reporting systems, VAERS has several limitations, including underreporting, unverified reports, inconsistent data quality, absence of a control group that is not vaccinated, and inadequate data about the number of people vaccinated. Indeed, an autism activist named Jim Laidler once reported to VAERS that a vaccine had turned him into The Incredible Hulk. The report was accepted and entered into the database, but the dubious nature thereof prompted a VAERS representative to contact Mr. Laidler, who then gave his consent to delete the report.[3]
originally posted by: NavyDoc
But neither of those papers mention vaccines and, scientifically, that certain metals can cause oxidation is a leap to connect them to this paper. Water causes drowning too, but it is all about the dose and timing and various other factors.
Abstract
Impaired brain function, excessive inflammation, and autoimmune manifestations are common in autism. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the necessary properties to induce neuroimmune disorders. Because peripheral immune stimuli in the postnatal period can compromise brain development and cause permanent neurological impairments, the possibility that such outcomes could also occur with administration of Al vaccine adjuvants needs to be considered. In regard to the risk of adjuvant toxicity in children, the following should be noted: (i) children should not be viewed as “small adults” as their unique physiology makes them more vulnerable to toxic insults; (ii) in adult humans Al adjuvants can cause a variety of serious autoimmune and inflammatory conditions including those affecting the brain, yet children are routinely exposed to much higher amounts of Al from vaccines than adults; (iii) compelling evidence has underscored the tight connection between the development of the immune system and that of the brain. Thus, it appears plausible that disruptions of critical events in immune development may also play a role in the establishment of neurobehavioral disorders; (iv) the same immune system components that play key roles in brain development appear to be targeted for impairment by Al adjuvants. In summary, research data suggests that vaccines containing Al may be a contributing etiological factor in the increasing incidence of autism.
...
Editors
Vinood B. Patel [email protected] (1)
Victor R. Preedy [email protected] (2)
Colin R. Martin [email protected] (3)
Editor Affiliations
1. Department of Biomedical Sciences, University of Westminster, Faculty of Science & Technology
2. Nutritional Sciences Division and Genomics Centre, King's College London
3. Faculty of Society and Health, Buckinghamshire New University
Authors
Lucija Tomljenovic [email protected] (4)
Russell L. Blaylock [email protected] (5)
Christopher A. Shaw [email protected] (6)
Author Affiliations
4. Faculty of Medicine, University of British Columbia, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada
5. Theoretical Neurosciences Research, LLC, Belhaven University, Jackson, 315 Rolling Meadows Rd., Jackson, MS, 39157, USA
6. Departments of Ophthalmology and Visual Sciences and Experimental Medicine, and the Graduate Program in Neuroscience, University of British Columbia, Neural Dynamics Research Group, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada
Focal brain inflammation and autism
Theoharis C Theoharides, Shahrzad Asadi and Arti B Patel
Abstract
Increasing evidence indicates that brain inflammation is involved in the pathogenesis of neuropsychiatric diseases.
Autism spectrum disorders (ASD) are characterized by social and learning disabilities that affect as many as 1/80
children in the USA. There is still no definitive pathogenesis or reliable biomarkers for ASD, thus significantly
curtailing the development of effective therapies. Many children with ASD regress at about age 3 years, often after
a specific event such as reaction to vaccination, infection, stress or trauma implying some epigenetic triggers, and
may constitute a distinct phenotype. ASD children respond disproportionally to stress and are also affected by food and skin allergies. Corticotropin-releasing hormone (CRH) is secreted under stress and together with neurotensin
(NT) stimulates mast cells and microglia resulting in focal brain inflammation and neurotoxicity. NT is significantly
increased in serum of ASD children along with mitochondrial DNA (mtDNA). NT stimulates mast cell secretion of
mtDNA that is misconstrued as an innate pathogen triggering an auto-inflammatory response. The phosphatase
and tensin homolog (PTEN) gene mutation, associated with the higher risk of ASD, which leads to hyper-active
mammalian target of rapamycin (mTOR) signalling that is crucial for cellular homeostasis. CRH, NT and
environmental triggers could hyperstimulate the already activated mTOR, as well as stimulate mast cell and
microglia activation and proliferation. The natural flavonoid luteolin inhibits mTOR, mast cells and microglia and
could have a significant benefit in ASD.
...
originally posted by: GetHyped
a reply to: ElectricUniverse
Do you think a resource that states vaccines can turn you into The Incredible Hulk is reliable? Yes/no.