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I don't think you've proved anything yet.
….Prions may be present but, is it the prion doing the damage or is the prion there because there was damage done? (Correlation does not simply equal causation, you know the argument.)
The function of a protein is determined by its shape.
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Identifying a protein's shape, or structure, is key to understanding its biological function and its role in health and disease.
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The structure of a protein determines its function.
Proper protein folding underlies proper protein function, since protein function is dependent on its proper three-dimensional conformation…. Misfolded proteins underlie a great number of cellular pathologies, such as amyloid fibrillogenesis (Alzheimer's), transmissible spongiform encephalopaties (prions), polyglutamine diseases (Huntington's), Parkinsons's lung emphysema (α1-antitrypsin), cystic fibrosis.
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Errors in protein synthesis disrupt cellular fitness, cause disease phenotypes and shape gene and genome evolution. ….Evolutionary responses to errors fall into two broad categories: adaptations that minimize errors and their attendant costs and adaptations that exploit errors for the organism's benefit.
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…crossbeta structure conformation comprising aggregates underlie various diseases, such as for instance Huntington's disease, amyloidosis type disease, atherosclerosis, diabetes, bleeding, thrombosis, cancer, sepsis, inflammatory diseases, rheumatoid arthritis, transmissible spongiform encephalopathies such as Creutzfeldt-Jakob disease, Multiple Sclerosis, auto-immune diseases, diseases associated with loss of memory such as Alzheimer's disease, Parkinson's disease and other neuronal diseases (epilepsy), encephalopathy, encephalitis, cataract and systemic amyloidoses. ….
A misfolded protein is defined herein as a protein with a structure other than a native, non-amyloid, non-crossbeta structure. ….At present (2007) over 30 misfolding diseases, …have been described as such.
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"These folded shapes are immensely important because they can define a protein's function in the cell," ….
….some protein shapes fit perfectly into cell receptors, turning chemical processes on and off, like a key in a lock. ….changing the shape of proteins, ….the key might no longer fit into the lock, and serious consequences in the body can occur when proteins fail to assume their preordained shapes or fail to connect properly.
"Misguided proteins have been linked to disease such as cancer, arthritis and wound healing, among others," LeDuc said. "Our research is looking at how protein shapes affect cells and how cell biomechanics impacts the entire process."
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…wrongly folded proteins are involved in the development of many diseases.
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Polymers of misfolded proteins underlie many diseases, including major neurodegenerative disorders. ….a range of disorders caused by misfolded proteins.
"Is it the prion doing the damage or is the prion there because there was damage done?"
Originally posted by soficrow
.........continued..........
The real questions are, "Where do most prions come from? What creates them? Are most prions created when we eat a bad diet, live a bad lifestyle and introduce prion-creating substances into our own bodies? …Or are prions mostly created somewhere else, and get into our bodies from "outside"? …and of course, What causes proteins to misfold?"
edit on 16/10/11 by soficrow because: formatedit on 16/10/11 by soficrow because: flow
Originally posted by colin42
Somewhere there is a corperate graph showing a bell curve. The poor, sick and old have been identified as ruining their bottom line and falling below a margin where they become unprofitable.
So how do they sell their cost cutting to us? Yep the sick, old and poor are to blame and it appears some are buying in to the hype.
From 1933 to 1945, Nazi Germany carried out a campaign to "cleanse" German society of individuals viewed as biological threats to the nation's "health." Enlisting the help of physicians and medically trained geneticists, psychiatrists, and anthropologists, the Nazis developed racial health policies that began with the mass sterilization of "genetically diseased" persons and ended with the near annihilation of European Jewry.
On July 14, 1933, the German government instituted the “Law for the Prevention of Progeny with Hereditary Diseases.” This law called for the sterilization of all persons who suffered from diseases considered hereditary, including mental illness, learning disabilities, physical deformity, epilepsy, blindness, deafness, and severe alcoholism. With the law’s passage the Third Reich also stepped up its propaganda against the disabled, regularly labeling them “life unworthy of life” or “useless eaters” and highlighting their burden upon society.
The term “euthanasia” (literally, “good death”) usually refers to the inducement of a painless death for a chronically or terminally ill individual. In Nazi usage, however, “euthanasia” referred to the systematic killing of the institutionalized mentally and physically disabled. The secret operation was code-named T4, in reference to the street address (Tiergartenstrasse 4) of the program's coordinating office in Berlin.
HEY!! That was the same excuse Hitler made! He made so many Germans mad at the chronically ill that it allowed him to gas most of the ill, paralyzed and mentally ill.
You and he may as well be twins. Aren't you proud of yourself?
Represented by the World Economic Forum (WEF), global corporate interests say the global economic crisis is caused by the chronic disease NCD Pandemic. They say it's sick people who are bankrupting nations, not corporate greed. And even though the evidence shows corporate industry creates the disease agents causing chronic disease, they blame the victims, insisting "people make themselves sick."
So, our planet is now riddled with disease agents created by corporate industry, up against the (noncommunicable disease) NCD Pandemic - corporate industry denies responsibility and liability, instead blaming victims for making themselves sick - governments are broke, and forced to go along with the farce.
......
Originally posted by Stratus9
reply to post by soficrow
HEY!! That was the same excuse Hitler made! He made so many Germans mad at the chronically ill that it allowed him to gas most of the ill, paralyzed and mentally ill.
You and he may as well be twins. Aren't you proud of yourself?
From 1933 to 1945, Nazi Germany carried out a campaign to "cleanse" German society of individuals viewed as biological threats to the nation's "health." Enlisting the help of physicians and medically trained geneticists, psychiatrists, and anthropologists, the Nazis developed racial health policies that began with the mass sterilization of "genetically diseased" persons and ended with the near annihilation of European Jewry.
On July 14, 1933, the German government instituted the “Law for the Prevention of Progeny with Hereditary Diseases.” This law called for the sterilization of all persons who suffered from diseases considered hereditary, including mental illness, learning disabilities, physical deformity, epilepsy, blindness, deafness, and severe alcoholism. With the law’s passage the Third Reich also stepped up its propaganda against the disabled, regularly labeling them “life unworthy of life” or “useless eaters” and highlighting their burden upon society.
The term “euthanasia” (literally, “good death”) usually refers to the inducement of a painless death for a chronically or terminally ill individual. In Nazi usage, however, “euthanasia” referred to the systematic killing of the institutionalized mentally and physically disabled. The secret operation was code-named T4, in reference to the street address (Tiergartenstrasse 4) of the program's coordinating office in Berlin.
www.ushmm.org...edit on 19-10-2011 by Stratus9 because: utter disgust and revulsion
The United States was the first country to concertedly undertake compulsory sterilization programs for the purpose of eugenics.[24] The heads of the program were avid believers in eugenics and frequently argued for their program. It was shut down due to ethical problems. The principal targets of the American program were the mentally retarded and the mentally ill, but also targeted under many state laws were the deaf, the blind, people with epilepsy, and the physically deformed. According to the activist Angela Davis, Native Americans, as well as African-American women[25] were sterilized against their will in many states, often without their knowledge while they were in a hospital for other reasons (e.g. childbirth). Some sterilizations took place in prisons and other penal institutions, targeting criminality, but they were in the relative[citation needed] minority. In the end, over 65,000 individuals were sterilized in 33 states under state compulsory sterilization programs in the United States