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When Sam starts to have flashbacks from his year as a soulless hunter before he contacted Dean, the brothers receive a message leading them to a small town where Sam spent time working on a case with their grandfather, Samuel.
It seems everyone is agreeing that soulless Sam should be left behind and just press forward with the show
Crowley is gone, so who would pull strings?
Echidna is a serpent woman, although I'm not sure she is considered a god. Typhoeus is her mate, so he will probably surface soon. From what I've read, they were responsible for creating some nasty monsters upon the earth.
Originally posted by q_ball
Maybe echidna is working with samuel, as mentioned for the next episode. I doubt samuel will still stop trying to get what he wanted and bring his wife back so maybe he is now trying this echidna (if they have such powers)