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A controlled clinical trial of DCA for the treatment of congenital lactic acidosis in children found that the drug was well tolerated at a dose of 12.5 mg/kg every 12 hours and blunted the increase in circulating lactate following a meal [5]. Patients received placebo for 6 months and then were randomly assigned to receive an additional 6 months of placebo or DCA. However, the drug failed to improve neurologic outcome. The efficacy of DCA was also evaluated for the treatment of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) [6]. The clinical trial ended early because of onset or worsening peripheral toxicity; all 15 of 15 patients randomized to DCA (25 mg/kg/day) were removed from the trial compared to 4 of 15 patients randomized to placebo. The authors concluded that DCA-associated neuropathy dominated the assessment of any potential benefit in MELAS.
Dr Evangelos Michelakis is living every researcher's worst nightmare. The therapy he painstakingly studied, verified and re-verified, has been hijacked and risks harming the very people it was meant to heal.
Originally posted by Phage
reply to post by angelx666
Chemotherapy and radiation therapy cured my cancer 22 years ago.
Originally posted by Phage
reply to post by angelx666
Chemotherapy and radiation therapy cured my cancer 22 years ago.
Originally posted by Phage
reply to post by angelx666
Chemotherapy and radiation therapy cured my cancer 22 years ago.