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Originally posted by DevolutionEvolvd
A build-up of Ketones in the blood can be very dangerous for type 1 diabetics and the condition is none as Ketoacidosis.
Fat is the perfect fuel. Part of it provides energy to the liver so that the liver can convert protein to glucose. The unusable part of the fat then converts to ketones, which reduce the need for glucose and sparing the muscle in the process.
If, instead of starving, you’re following a low-carb diet, it gets even better. The protein you eat is converted to glucose instead of the protein in your muscles. If you keep the carbs low enough so that the liver still has to make some sugar, then you will be in fat-burning mode while maintaining your muscle mass, the best of all worlds. How low is low enough? Well, when the ketosis process is humming along nicely and the brain and other tissues have converted to ketones for fuel, the requirement for glucose drops to about 120-130 gm per day. If you keep your carbs below that at, say, 60 grams per day, you’re liver will have to produce at least 60-70 grams of glucose to make up the deficit, so you will generate ketones that entire time.
So, on a low-carb diet you can feast and starve all at the same time. Is it any wonder it’s so effective for weight loss?
Ketoacidosis is an extreme and uncontrolled form of ketosis, which is a normal response to prolonged fasting. In ketoacidosis, the body fails to adequately regulate ketone production causing such a severe accumulation of keto acids that the pH of the blood is substantially decreased.
snip
In diabetic patients, ketoacidosis is usually accompanied by insulin deficiency,
Originally posted by IntastellaBurst
We all know hormones dont make you fat, ... however they can regulate fat gain, ... and where you gain it. One of the leading causes of weight gain is simple sugars, ... soda, white flour, candy. They cause a huge spike in insulin storing all the calories then making you crash feeling hungry again. ... its like crack for your body.
.... I've been going up and down for years, It amazes me how little people actualy know about nutrition, and physiology. To me weight loss is like a science, ..... but theres so many things you can do which seem effortless, ........ if u want to cheat, make it for breakfast, that way u can burn it off, ... and it will boost your metabolism. .... no carbs after a certain time.
.... what you have to understand is, ... the body cannot burn fat 24 hours a day, .... however the key is to optimize the times when you do burn bodyfat, ...... the greatest being ... when you sleep.
.... I can go on and on ..... I should write a book.
Originally posted by DevolutionEvolvd
I will agree that energy balance does play a role in weight gain/loss. Obesity, however, is a disease of excess fat accumulation. It's a fat problem, not a weight problem. Even in a negative energy balance, if insulin is present in the system, fat will not be released from the cells to be burned for energy.
If the body needs energy, in this case, it will breakdown muscle tissue to convert amino acids into glycogen. Weightloss is a result of this, but it's not fat loss.
-Dev
Edit: Anorexia used to be treated with insulin
Originally posted by DevolutionEvolvd
Even in a negative energy balance, if insulin is present in the system, fat will not be released from the cells to be burned for energy.
Originally posted by ImaginaryReality1984
So you're telling me that you think if you take an obese person, completely eliminate all food intake and lock them in a room that they will not lose any weight because they have insulin in their system? You do know you just stated an absolute right?
I can see what you're trying to say but you are sadly being blinded here. Their bodies will burn fat. If they exercised, dosing with protein to reduce muscle loss then their body will use the fat. How do you explain obese people that have lost their weight on a negative calorie diet?
I agree that the hormonal role has been underresearched. However saying that obese people cannot lose fat is an absolute load of rubbish. If this were true then all those people who have lost their weight and have to have operations to remove the skin folds must be freaks of nature! In fact they are not freaks, they just had the will power to lose their excess fat.
You have taken a good theory and are pushing it to extremes. Obese people need to take responsibility for their own condition. Oh and finally i will add this.
My grandad was an insulin using diabetic and he was very over weight. You stated earlier this isn't possible but there is clear medical evidence to the contrary.
You are applying this science far to broadly and far to simply.
Originally posted by DevolutionEvolvd
I'm saying they won't lose fat. Weight loss if inevitable is you're starving someone. They're body will break down muscle tissue into amino acids, convert amino acids into glycogen for energy, and fat will remain in the cells, initially. But, if you lock someone in a room long enough without food, their it won't very long, possibly a day or two, for their insulin levels to drop. Ketosis will then begin. This is absolutely true.
Originally posted by DevolutionEvolvd
Lab studies have shown that animals can die if placed on a starved while injecting insulin in the system. They die without any loss of fat. I guess I need to dig around for these studies. It will take me some time though.
Originally posted by DevolutionEvolvd
The weight loss is seen in muscle loss, by the process described above, and/or fat loss, restricting total calories will in almost every case restrict carbohydrates, thereby diminishing insulin.
Yes, exercise can cause a decrease in body fat. I'm not arguing that. I'm saying it's not needed and will inevitably make you hungrier. I know from personal experience that exercising will burn the blood glucose and therefore lower blood insulin. Because if glucose is burned, insulin is not need to store it.
Originally posted by DevolutionEvolvd
I honestly have no idea where you got the idea that I thought obese people cannot lose fat. Lowering insulin levels by lowering carbohydrate intake will cause fat to be released from fat cells to be burned for energy.
Originally posted by DevolutionEvolvd
I'm not pushing anything other than facts. These were realized long ago be many researchers and has been thrown under the rug ever since. Long forgotten. This stuff is in biochemistry text books from over 50 years ago.
Originally posted by DevolutionEvolvd
You're grandad would not have been able to gain weight unless he injected insulin after every meal. My point was that type 1 diabetics can't naturally gain weight unless they supplement with insulin.
Originally posted by DevolutionEvolvd
I'm really not. I'm telling you that obesity is excess fat accumulation. I'm telling you that fat accumulation is regulated by insulin. I'm telling you that carbohydrates and insulin cause fat to be stored. I'm telling you that excess insulin locks fat in cells. I'm telling you that fat cells are not dump trucks for excess calories.
Originally posted by DevolutionEvolvd
This is not broad, this is how the body works. Have you watched the video? Just take 1 hour to watch it.
Originally posted by DevolutionEvolvd
When you make obesity an energy balance problem it becomes psychological, but when you make it a fat deposition problem it becomes physiological. It becomes easier to remedy in the latter.
Originally posted by Dumbfirefly
It is important to remember that carbohydrates have always formed the staple component of many different diets - cereal crops, bread and potatoes in the UK and Europe, rice, noodles and dumplings in most of Asia etc etc. It has been this way for generations. Obesity, however, is a very recent phenomenon owing to the excessive consumption of every food group, the explosion in "junk food" and the sedentary lifestyle of modernity.
Originally posted by Dumbfirefly
Like I said before, most hormone problems are an effect of obestiy, not a cause. Regardless, hormones cannot make fat out of nothing; you can only gain the fat from food intake.
Originally posted by ImaginaryReality1984
That is what baffrles me here. If these people who are going on about insulin resistance and the role of insulin took an obese person and starved them then that person would lose weight. It's really that simple.
Whilst insulin resistance may increase obesity it should be noted that insulin resistance usually comes about in healthy people when they indulge in the wrong foods. This is why we're seeing more obese children, because they are gorging on the sugar laden foods. The body learns to adapt and increases insulin production and this becomes a vicious cycle.
They start gaining weight because they are taking in to many calories. Their body becomes resistant to insulin and so the weight packs on faster.
Honestly if you take someone with massive insulin resistance and eliminate all refined sugar (or as much as possible) whilst also limiting the amount of simple carbohydrates they eat and finally limit the number of calories they intake to less than they need, you will see a dramatic loss of weight and their insulin resistance will clear up.
Originally posted by Dumbfirefly
There are many causes of insulin resistance. It can be pregnancy, obesity, medication, metabolic syndrome and so on. The fact that obesity is listed as a cause of insulin resistance (and, relatedly, type 2 diabetes) says that it is not a cause of obesity, per se.
In the wikipedia page you linked, there is an interesting quote that I feel puts the relevance of Insulin Resistance in the issue of the causes and effects of obesity into good perspective:
"The primary treatment for insulin resistance is exercise and weight loss"
Like I said before, most hormone problems are an effect of obestiy, not a cause. Regardless, hormones cannot make fat out of nothing; you can only gain the fat from food intake.
[edit on 29/6/09 by Dumbfirefly]
Obesity is not a cause of insulin resistance. Hyperinsulinemia is. And hyperinsulinemia also causes obesity.
That's the current though, yes. But it doesn't address the core cause of obesity and insulin resistance. It's insulin. Yes, most hormone problems are an effect of obesity and even insulin resistance, but the original one that caused it all is insulin. That's THE hormone that controls, regulates or affects all other hormones in the body, so when it's out of whack, so are the others.
Insulin is also the ONLY hormone that lowers blood sugar while there are multiple hormones that raise blood sugar. Insulin lowers glucose by storing it as fat. Dietary Fat cannot be stored without Alpha Glycerol Phosphate, an enzyme that converts triglycerides into fatty-acids. An enzyme that is only found in carbohydrates. Fat will not be released from fat cells if insulin is elevated.
Insulin, a hormone, won't make fat out of nothing but in the absence of insulin and alpha glycerol phosphate, fat will not be stored.