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Pharmaceuticals and personal care products (PPCP's) are continually infused into the environment via sewage treatment facilities and wet weather runoff. In many instances, untreated sewage is discharged into receiving waters (e.g., flood overload events, domestic "straight-piping," or sewage waters lacking municipal treatment). In the United States alone, possibly more than a million homes do not have sewage systems but instead rely on direct discharge of raw sewage into streams by straight-piping or by outhouses not connected to leach fields (1). A number of Canadian cities are reported to discharge 3.25 billion liters per day (over 1 trillion liters per year) of essentially untreated sewage into surface waters and the ocean..
The hypothesis is further complicated by the fact that while the concentration of individual drugs in the aquatic environment could be low (sub-parts per billion or sub-nanomolar, often referred to as micropollutants), the presence of numerous drugs sharing a specific mode of action [color=gold]could lead to significant effects through additive exposures. It is also significant that drugs, unlike pesticides, have not been subjected to the same scrutiny regarding possible adverse environmental effects. They have therefore enjoyed several decades of unrestricted discharge to the environment, mainly via sewage treatment works.
A striking difference between pharmaceuticals and pesticides with respect to environmental release is that pharmaceuticals have the potential for ubiquitous direct release into the environment worldwide--anywhere that humans live or visit. Even areas considered relatively pristine (e.g., national parks) are subject to pharmaceutical exposures, especially given that some parks have very large, aging sewage treatment systems, some of which discharge into park surface waters and some of which overflow during wet weather events and infrastructure failures (e.g., Yellowstone National Park)
Some drugs are excreted essentially unaltered in their free form (e.g., methotrexate and platinum antineoplastics), often with the help of active cellular "multidrug transporters" for moderately lipophilic drugs. Others are metabolized to various extents, which is partly a function of the individual patient and the circadian timing of the dose (the P450 microsomal oxidase system is a major route of formation of more polar, more easily excreted metabolites). Still others are converted to more soluble forms by formation of conjugates (with sugars or peptides).
The subsequent transformation products--metabolites and conjugates from eukaryotic and prokaryotic metabolism, and from physicochemical alteration--add to the already complex picture of thousands of highly bioactive chemicals. The FDA refers to all metabolites and physicochemical transformation products, for example, those that range from the dissociated parent compound to photolysis products, for a given drug as structurally related substances (SRSs), which can have greater or lesser physiologic activity than the parent drug.
Sewage treatment plants. Treatment facilities, primarily POTWs or sewage treatment works (STWs), which include privately owned works as well, play a key role in the introduction of pharmaceuticals into the environment [see Rogers (19) for a review of the fate of synthetic chemicals in sewage treatment plants]. STWs were designed to handle human waste of mainly natural origin
A major unaddressed issue regarding human health is the long-term effects of ingesting via potable waters very low, subtherapeutic doses of numerous pharmaceuticals multiple times a day for many decades. This concern especially relates to infants, fetuses, and people suffering from certain enzyme deficiencies (which can even be food-induced, e.g., microsomal oxidase inhibition by grapefruit juice).
According to the National Research Council (NRC) (25), more than two dozen major U.S. utilities release so much effluent to receiving waters that when the natural flows are low, the discharged waste composes 50% of the eventual flow. Any residual, unidentified contaminants therefore are diluted 2-fold at best. In more densely populated countries (e.g., United Kingdom), this figure can rise [color=gold]as high as 90% of flow during times of low rainfall (26).
Originally posted by battlestargalactica
p.s. 1ppm = 1mg/l = 1000ppb (for water) for those that don't have the conversion..
Originally posted by Damocles
im sure it was just a math error..
Originally posted by battlestargalactica
Yes I am sure your error is just a math error, but lets not make these numbers look COMPLETELY WRONG due to bad math and you not doing your homework mmkay?
Originally posted by battlestargalactica
reply to post by Damocles
I was formulating your sample question for you to answer with the edits
Did you get to it?
ppm and ppb are pretty simple, it's when you confuse things with mg/liter and µg/liter. If you got confused with ppm and ppb, you'd really get confused with the city water quality reports since they seem to mix units and use different one for different compounds.
mg/l = 1000 µg/l basically again.
Also, if I seemed like a dick its because you basically accused me of tampering with equations in order to inflate my numbers,
a groundless accusation, and an accusation that was completely false using your bad math.
The concentration can be quite confusing, I think they do it on purpose to screw with us