Covid & The Smokers Paradox

a reply to: infolurker


in a word nicotine, years ago i read a article and heard it on right wing whacko radio that nicotine it was the suspected reason that smokers weren't getting sick like non smokers during not sure what kind of out break it was then, and that smokers that worked in some chemical plants didn't get as sick as non smokers due to the chemicals.

that was right before the big push / ban on smoking and the taxes federal and states started putting on them to make people stop.

turns out there might have been something to it. not so much the smoking and all the other sh@@ put in cigarettes and the effects that they cause for smokers it's the nicotine.

a abstract and a articles about it.

first the articles,

However, French researchers led by Jean-Pierre Changeux, a neurobiologist at the Institut Pasteur, suspect that nicotine patches could help prevent infections with the dangerous virus. They have published a corresponding hypothesis on the science portal Qeios
Does nicotine help against the new coronavirus?

and the article link from the one above,

Although selective cytokine blockers (eg, IL1-receptor antagonist anakinra or anti-IL6 tocilizumab) have been proposed for the control of Covid-19 cytokine storm, their efficacy is still to be explored. Interestingly, 𝛼7 agonists, including nicotine, have proven to be effective in reducing macrophage cytokine production and inflammation in animal models of pancreatitis [32] and peritonitis [33]. In this setting, a nicotinic treatment that might possibly antagonize the blocking action of SARS-CoV-2 on the AChR through a possible modulation of the ACE2 – nAChR interaction, would act earlier than anti-cytokine therapies. nAChR modulation by Covid-19 might tentatively account for the hyperinflammatory features observed in a subgroup of Covid-19 patients, mimicking bona fide the macrophage activation syndrome.
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

the abstract which has links to the study PDF's, that is a PDF warning.

Abstract
There is an urgent need to address the devastating pandemic, COVID-19, caused by SARS-CoV-2. The efforts to understand the details of this disease in hope of providing effective treatments are commendable. It is clear now that the virus can cause far more damage in patients with comorbid conditions-particularly in those with respiratory, cardiovascular, or immune-compromised system-than in patients without such comorbidities. Drug use can further exacerbate the condition. In this regard, the ill effects of smoking are amply documented, and no doubt can be a confounding factor in COVID-19 progression. Although conflicting hypotheses on the potential role of nicotine in COVID-19 pathology have recently been offered, we believe that nicotine itself, through its interaction with the nicotinic cholinergic system, as well as ACE2, may not only be of use in a variety of neuropsychiatric and neurodegenerative diseases, but may also be of potential use in COVID-19. Thus, on one hand, while we strongly support smoking cessation as a means of harm reduction associated with COVID-19, on the other hand, we support a potential therapeutic role for nicotine, nicotinic agonists, or positive allosteric modulators of nicotinic cholinergic receptors in COVID-19, owing to their varied effects including mood regulation, anti-inflammatory, and purported interference with SARS-CoV-2 entry and/or replication.

Nicotine and the nicotinic cholinergic system in COVID-19

a reply to: BernnieJGato

Well, it is a bit funny, that during the Spanish flu outbreak, it was noticed smokers were not getting sick.a lot of people started to smoke . This was a Coronavirus as well. So if it was a bioweapon that nicotine could stop in its tracks they would have to try and wipe out the habit, and they certainly tried and were financed by the same people that brought you the big pharma products. The push for anti-smoking was the biggest push in social engineering that we have seen since the mask and jab mandates. There are proven health benefits of smoking, Far lower incidence of Parkinson's and Altzihers, far lower hip and knee replacement surgery, it is an appetite suppressor, Note when smoking was the rage obesity was rare. Gates and his crew have been trying for ages to get the nicotine content in the leaf down with GMO, like he actually cares about your health, the only thing he cares about is his bank account. Pipe smokers live longer than nonsmokers etc I could go on but the brainwashing on this subject has been good. Moderate smoking never killed anyone.

I'm a smoker never got sick or had the vax. I thought there was a hypothesis that because smokers had a lot of tar in their lungs that the virus would get stuck on the tar and not have a chance to replicate.

I don't know if smoking tobacco decreases the risk of catching covid but i know for sure when I light up people tend to # off and respect my 2-meter exclusion zone.

a reply to: infolurker
Good to learn of the smokers paradox studies. When it was first identified smokers being under-represented on the covid wards, the assumption seemed to be this was nicotine related. Too simple I thought.

Smokers may have larger lung capacity.

a reply to: Soloprotocol

I am going to introduce a "thought" here and ask for some feedback

The truth is that smoking, like everything else in the world, has benefits and also has drawbacks. Certainly, as has been pointed out, alcohol is far more damaging. Yet the government went after smoking....mmm... now as a part of the anti-smoking campaign, the government banned smoking in so called public places that are actually privately owned. For example, bars anad restaurants. Operators of these extablishments could have simply put a sign saying smoking allowed or smoking not allowed. Then people could make up their mind, which type of extablishment they wanted to attend.

Simarly, the laws brought in to regulate the sale of tobacco were so onorous that, in truth, most convenience stores could not afford to sell tobacco. In Ontario, 2500 convenience stores closed their doors forever.

BUT the rusult of all this regulation, was that a very scary principle was clearly established. The government could take it upon themselves to regulated things to ridiculous lengths to protect public health. Thus, even though we already know that the death rate of covid was less than 1.5 percent, the government justified lockdowns to ridiculous lengths to "protect public health". In Canada criminal fines ectera were imposed, all justified by threats to public health

So we now have governments who can suspend human rights, constitutional rights etc. as public health is deemed to be of more importance.

All precendences set by anti-tobacco.

Any thoughts

Interesting. I have an anecdote that is along these lines.

Years ago I considered taking employment overseeing a chicken warehouse production facility on a medium size farm. The farmer needed somebody to keep an eye on the chickens, cull the sick and dead, etc. This was a large four warehouse facility that raised the birds for one of the larger producers like Sanderson Farms (though i disremember precisely which it was). It was in some wys a nice position as I'd have been afforded a house in the country on the quite, rural farm property and a salary. I was sore tempted, but ended up not taking it.

I spent a couple of days on site to get a feel for the job. The main reason that I turned it down was that the environment inside the chicken barns was hell on my lungs. I would have had to use a high level respirator due to the presence of amonia and who know what else in the air in those damned warehouses.

The farmer had had a few different people work that position over the years. He asked me if I smoked or had ever smoked. I said no, he said he didn't think so. He said that smokers didn't tend to have a hard time being in the barns without respirtors.

Like this, it seemed paradoxical. I'd have thought that healthy lungs could handle the environmental contaiments better, but it was the other way around.

a reply to: TiredofControlFreaks

Same with seat belts.

a reply to: incoserv

You are correct sir! Seat belt laws set the precedence for anti-tobacco laws.

a reply to: infolurker

that include ACE2 receptor protection and possibly radioactivity in tobacco could be blocking the Covid receptors themselves

That was known from the start .
A UK tobacco company put forward a recommendation , which was widely accepted at the time .
Then the bulls__ started .
Crushed it .

originally posted by: TiredofControlFreaks
a reply to: incoserv

You are correct sir! Seat belt laws set the precedence for anti-tobacco laws.

There are no US Federal government laws regarding seat belts.

a reply to: Gothmog

i am canadian. are there states laws requiring the use of seat belts. And did anti-tobacco campaigners use seatbelt laws to justify ant-tobacco laws on the basis of need to protect public health?

originally posted by: BernnieJGato
a reply to: infolurker


in a word nicotine, years ago i read a article and heard it on right wing whacko radio that nicotine it was the suspected reason that smokers weren't getting sick like non smokers during not sure what kind of out break it was then, and that smokers that worked in some chemical plants didn't get as sick as non smokers due to the chemicals.

that was right before the big push / ban on smoking and the taxes federal and states started putting on them to make people stop.

turns out there might have been something to it. not so much the smoking and all the other sh@@ put in cigarettes and the effects that they cause for smokers it's the nicotine.

a abstract and a articles about it.

first the articles,

However, French researchers led by Jean-Pierre Changeux, a neurobiologist at the Institut Pasteur, suspect that nicotine patches could help prevent infections with the dangerous virus. They have published a corresponding hypothesis on the science portal Qeios
Does nicotine help against the new coronavirus?

and the article link from the one above,

Although selective cytokine blockers (eg, IL1-receptor antagonist anakinra or anti-IL6 tocilizumab) have been proposed for the control of Covid-19 cytokine storm, their efficacy is still to be explored. Interestingly, 𝛼7 agonists, including nicotine, have proven to be effective in reducing macrophage cytokine production and inflammation in animal models of pancreatitis [32] and peritonitis [33]. In this setting, a nicotinic treatment that might possibly antagonize the blocking action of SARS-CoV-2 on the AChR through a possible modulation of the ACE2 – nAChR interaction, would act earlier than anti-cytokine therapies. nAChR modulation by Covid-19 might tentatively account for the hyperinflammatory features observed in a subgroup of Covid-19 patients, mimicking bona fide the macrophage activation syndrome.
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

the abstract which has links to the study PDF's, that is a PDF warning.

Abstract
There is an urgent need to address the devastating pandemic, COVID-19, caused by SARS-CoV-2. The efforts to understand the details of this disease in hope of providing effective treatments are commendable. It is clear now that the virus can cause far more damage in patients with comorbid conditions-particularly in those with respiratory, cardiovascular, or immune-compromised system-than in patients without such comorbidities. Drug use can further exacerbate the condition. In this regard, the ill effects of smoking are amply documented, and no doubt can be a confounding factor in COVID-19 progression. Although conflicting hypotheses on the potential role of nicotine in COVID-19 pathology have recently been offered, we believe that nicotine itself, through its interaction with the nicotinic cholinergic system, as well as ACE2, may not only be of use in a variety of neuropsychiatric and neurodegenerative diseases, but may also be of potential use in COVID-19. Thus, on one hand, while we strongly support smoking cessation as a means of harm reduction associated with COVID-19, on the other hand, we support a potential therapeutic role for nicotine, nicotinic agonists, or positive allosteric modulators of nicotinic cholinergic receptors in COVID-19, owing to their varied effects including mood regulation, anti-inflammatory, and purported interference with SARS-CoV-2 entry and/or replication.

Nicotine and the nicotinic cholinergic system in COVID-19

my hats off to anything
that can get by my lungs.

i 'm a heavy smoker for decades.





i tested positive once for covid after my shots, only took the test coz the wife made me.
i had some sniffles but i passed it off as some allergy. next day tested neg.
i 'm sure the 3 paks knocked it right out.

but who knows what these tests test. given the covid CTs out there, the tests could be rigged so every little hypochondriac symptom gets tested positive. lol pfizer doctor in a box. your own private fauci.

i won' get started on smoking, i' old enough to remember refueling and people smoking at the same time
until common sense prevailed and people said, maybe it's not a good idea and i've heard about more vape pens and iphones lighting people up than gas stations exploding.

and those airport smoking rooms! OMG! wtf ?! seriously?

2nd hand smoke, lol. my lungs already got the good stuff and filtered it for everyone else.

just my 4 1/2 cents. .

a reply to: incoserv

When they did a check on how many of the workers in the asbestos mine died of asbestosis. They found that smokers seemed to miss dying of it. Another fact that was quickly forgotten when the narrative gets dumped.

a reply to: teapot

It has been called the Asian paradox and the French paradox. This seems to suggest that everything that has been blamed on smoking, in reality, is diet, I am not suggesting that chain-smoking is healthy, but if you look at the general health of the population before and after the smoking bans and the ridiculous price they are charging for a pack of smokes. It is about the same as before and after mandated vaccines. Just a continuous raft of # ups.

I found out the hard way how different commercial cigarettes are compared to organic tobacco roll your own. I was a pack a day smoker and had to quit as I could barely make it up a flight of stairs without feeling like my lungs were gonna collapse.

I ended up trying the organic roll your own tobacco on the advice of a friend and wow 😳 what a difference at how my lung caps increased. The organic tobacco actually seems to act as a bronchodilator and cough expectorant. It appeared these components are missing from the commercial cigarettes. I noticed the effects right away and now firmly believe it is medicinal.

a reply to: infolurker

I have a personal story.

My mom was a chain smoker. She was diagnosed with lung cancer right smack in the middle of Covid, Feb 2020.
She came to live with me and I took care of her day in day out for about a year.
We went to hundreds of doctors appointments. That is not an exaggeration, I added them up and it was about 200 so appointments conservatively. Some days we had up to 6 appointments. The both of us basically lived in the hospital.
My mom was horrible with the mask and it was often on weird and askew. We were in the ICU one day and there was a commotion down the hall, they were intubating someone. Lots of Covid patients.

My mom never got it, not one single time. She was tested several times, and in close contact a few times, and her immune system was shot, and she never got it. She smoked up to three days before she passed.

She was not vaccinated, and she had not had covid prior.

a reply to: JAGStorm


My personal story is about an uncle that smoked three packs of Capstan navy cut untipped. Every day of his life since the first world war. He was convinced to give it up at ninety-two because of cost. Two years later he died of Alzheimer's.I did a bit of research and found that the oldest people in the world are smokers, so a conspiracy theorist would have some fun with that.

a reply to: Wide-Eyes

That is the same with all of the radioactive fallout from all the nuclear testing they have done.

Smoking has huge benefits which is why democrats are working against smoking again, and once again demonizing it.

In fact look into project trinity, after the first causes of cancer started to hit people. Thousands of years with no cancer, and then nuclear testing has put enough dust in the atmosphere enough to give everyone on earth cancer 112x over. So government like always found a fallout(just like they did with pot).

a reply to: TiredofControlFreaks

I would be more inclined that the push against smoking is the filters, the smoke etc... Climatology/environmentalist have a field day when it comes to attacking smokers.

But what they don't realize is that if a large enough population actually smokes (and we come up with something better then those non biodegradable filters) it has a cooling effect on the planet. (Think volcano smoke - it's been proven to reduce tempatures).