Methylene Blue for Alzheimer's, Dementia, Parkinson's and UTIs

originally posted by: asabuvsobelow
a reply to: chr0naut

At 11.2 billion doses administered now, and with 2 years of clinical data, I would think it is one of the best tested medicines in human history.

I would almost agree aside from one thing .

Why the hold out on releasing the overall findings and Data of the Vaccine and it's effects ?

It wasn't Pfizer holding it back. The hold-up was in the FDA processing and releasing the data. Even then, a judge has overturned that:

Judge scraps 75-year FDA timeline to release Pfizer vaccine safety data, giving agency eight months - Washington Examiner

originally posted by: puzzled2
a reply to: chr0naut

So strange you express caution for this, but advocate for mass injection of a weakly tested substance, that has a formula that changes at the will of the producers and not tested.

Perhaps the problem you have is with the lack of profit not the lack of benefit.

Is this the reason you're so negative?

Key findings
The present study indicated the ability of MeBlu to suppress the interaction between SARS‐CoV‐2 S protein and hACE2. Importantly, researchers reported that this dye can inhibit the SARS-CoV-2 Delta strain, which has been categorized as a variant of concern (VOC). This study reinforced the potential of the MeBlu dye compound as a cost-effective therapeutic antiviral treatment for SARS-CoV-2 infection.

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

The quoted studies ALL used injected methylene blue, which also has some noted adverse interactions. None of the quoted studies (into possible effects on Alzheimers, or as an antiviral, or in prevention, and/or treatment, of blood clots) used orally administered methylene blue.

When, in the article, they spoke of the relative safety of methylene blue, they were specifically referring to the safety of low dose ORAL methylene blue tablets. This is a misrepresentation of the studies, and of the known clinical safety data, which used injected methylrne blue.

originally posted by: andr3w68
a reply to: chr0naut

First off, I think we can all agree that something taken orally is going to have different effects to something taken intravenously. This makes your post mostly irrelevant to what puzzled was saying. You can't compare apples to oranges as much as so many like to do these days.

Secondly, had you of actually looked at ORAL MB you would see that the list of side effects is actually pretty small with no severe effects listed, also making your post mostly irrelevant.

WEBMD - Side effects

In conclusion, thread derailment to push a narrative is bad, mkay.

All the listed studies did not use low-dose oral methylene blue tablets. The safety of the tablets is beside the point because no-one is saying that these effects are seen in those taking low-dose tablets.

All cases in the studies referenced used injected methylene blue solutions.

a reply to: chr0naut

11.2 Billion doses of what? There is over 37 to choose from. source Bit of a fake news to claim lack of problems based on that number

You mention Clinical data - where is this data - where is the follow-up on the 11.2 Billion doses?

There has been more doses of Ivermectin issued since it was discovered, yet you don't advocate the rush to go out and cure everyone of a parasitic infection to prevent deaths and illness caused by the things it does well against do you?

Back to MB problems with SSRIs as SSRIs are primarily for depression source and come with a multitude of side effects on their own.

If someone is suffering from Dementia would it be better to treat that, rather than the depression caused by them having dementia.

Finding a cure for dementia or even better a preventive should far out way the profit from issuing SSRI's.

a reply to: crankyoldman

Thanks for the reply.

So whilst your were taking it, did you experience better metabolic health or was it an overall feeling of being better mentally and physically?

originally posted by: puzzled2
a reply to: crankyoldman

Thanks for the reply.

So whilst your were taking it, did you experience better metabolic health or was it an overall feeling of being better mentally and physically?

I'd say overall feeling, but I can't say I have anything that it might impact directly.

Information

All you guys can do is argue about Covid when the thread is about Alzheimer's and other illnesses. My Mom recently died from Alzheimer's and that's what this thread is supposedly about and all you guys can do is argue, what?

Crikey, stay on topic guys and to Crankyoldman, dude, really? You bring up three "sorts" of people but can only name two? Really? Is this what we are doing these days?

There are three sorts of people. Those who know enough about themselves and their body to try new things based on research and intuition. Those who are in the fence and those who only follow dogma and fear most things. If you fall into the first category I say research. Amazon has the recommended brand, powder just add purified water. And watch the staining.

This is what "civilized" debate is nowadays? I had to watch my Mom 's mind turn into oatmeal from Alzheimer's and you want to turn the debate into this crap? She read more books than most people on this forum have read and her mind turned into mush and you want to turn this into a Covid debate?

What the hell is wrong with you all?

a reply to: puzzled2

"Methylene Blue"

I dont think the wean has that plushy yet.

Sounds like Pokémon.

My Gran had dementia brought about by osteoporosis according to her Doctors.

Don't ever remember her being prescribed "Methylene Blue" but if it shows promise that's great, i hope it manages to help people, that is of course as long as it does what it says on the tin.

originally posted by: puzzled2
a reply to: chr0naut

11.2 Billion doses of what? There is over 37 to choose from. source Bit of a fake news to claim lack of problems based on that number

You mention Clinical data - where is this data - where is the follow-up on the 11.2 Billion doses?

Apparently there are 450,000 pages of it, that we are waiting for the FDA to approve and release (as per the previously linked Washington Examiner news article). Yet the quoted number of documents is specifically related only to the Pfizer vaccine.

Imagine how much data the FDA must have to read, understand, and approve for release, if there is actually 37 times more than just the Pfizer data alone?

There has been more doses of Ivermectin issued since it was discovered, yet you don't advocate the rush to go out and cure everyone of a parasitic infection to prevent deaths and illness caused by the things it does well against do you?

So you just pull a number out of the air? Well, here's my workings to refute your guess:

According to CliniCalc, there have been 797,171 prescriptions filed for Ivermectin in the US between 2014 and 2019. That averages to 159,434.2 prescriptions per year (2017 being the peak year). Multiply that by the 47 years that Ivermectin has existed (invented and registered in 1975) = roughly 7,493,407 prescriptions in the US since it came on the market.

Of course this would be considered a maximum number, because Ivermectin use increased over time in the US, as did population.

The US roughly represents 4.35% of the global population, so that means you would have to multiply US numbers by 22.988 to approximate world numbers. This equals, roughly, 172,262,239 prescriptions for Ivermectin, in the world, since it became available.

But, of course, that is the number of prescriptions, not of doses. So we need to determine how many doses are, on average, in a prescription.

Normally, Ivermectin is prescribed in daily tablet doses over a number of days. So it would therefore be a single dose per day, at maximum.

The average daily dosage can be calculated from data provided on CliniCalc that compares average cost of prescription per user, to the average daily cost of prescription per user. This reveals that, on average, each prescription was for 6 daily doses. So if we multiply the total estimated number of prescriptions in the world by 6, we will have a close estimate of the total number of doses of Ivermectin, in the world, over the last 47 years = 1,033,573,434 doses.

Ivermectin doses, therefore, account for only roughly a 10th of the doses of COVID-19 vaccines administered to date.

One source for my calculations: Ivermectin Drug Usage Statistics, United States, 2013 - 2019 - CliniCalc

Back to MB problems with SSRIs as SSRIs are primarily for depression source and come with a multitude of side effects on their own.

If someone is suffering from Dementia would it be better to treat that, rather than the depression caused by them having dementia.

Finding a cure for dementia or even better a preventive should far out way the profit from issuing SSRI's.

Methylene blue has not yet been established as a clinical norm for the treatment of dementia. Until it gets approval, it could be considered experimental for the treatment of the condition. So, anyone who takes it prior to grant of approval, is doing so entirely experimentally.

And, I agree the a solution to dementia is more pressing than one to depression, however there is existing approval for use of antidepressants, but there is a noted negative interaction between SSRI's and methylene blue (from other approved uses of the compound).

So, the simple solution is that if someone wants to take methylene blue, then they should wean themselves off any SSRI's they may be taking, well before taking the methylene blue.

a reply to: chr0naut

Pick a country with the lowest use of a drug why don't you.
Merck has

Through the efforts of a variety of partners, more than 4 billion treatments have been donated to 49 countries in Africa, Latin America, Eastern Mediterranean, Asia, and South Pacific.

so that's the free ones. Try looking at the countries that use it for serious disease prevention not cherry pick to suit your agenda.

But sticking to the topic at hand

So, the simple solution is that if someone wants to take methylene blue, then they should wean themselves off any SSRI's they may be taking, well before taking the methylene blue.

You are not a dispensing doctor, not any form of medical expert but on a forum -
So why are you giving out medical advice?
Why are you not discussing the research and if you must mention safety concerns only refer anyone considering using a
treatment to refer to their medical provider?

For people wanting to get more information on Methylene Blue from experts in the field try

Alzheimer’s Disease (AD) and Methylene Blue: Looking Into Past and Current Drug Therapies
STEM-Talk: Episode 107
Francisco Gonzalez-Lima discusses methylene blue and near-infrared light as therapies for cognitive disorders.

If anyone has other links please share.

Thank you.

originally posted by: puzzled2
a reply to: chr0naut

Pick a country with the lowest use of a drug why don't you.
Merck has

Through the efforts of a variety of partners, more than 4 billion treatments have been donated to 49 countries in Africa, Latin America, Eastern Mediterranean, Asia, and South Pacific.

so that's the free ones. Try looking at the countries that use it for serious disease prevention not cherry pick to suit your agenda.

But sticking to the topic at hand

So, the simple solution is that if someone wants to take methylene blue, then they should wean themselves off any SSRI's they may be taking, well before taking the methylene blue.

You are not a dispensing doctor,

No, I am not. I made no such claim.

not any form of medical expert but on a forum -
So why are you giving out medical advice?

I was only pointing out a warning about an interaction noted by several highly qualified authorities. I even provided references to my sources.

And, as someone who has suffered serotonin syndrome (due to a drug interaction between migraine medication, an SSRI, and pain killers), I have some personal experience of what can happen.

Why are you not discussing the research and if you must mention safety concerns only refer anyone considering using a treatment to refer to their medical provider?

I can ask you exactly the same questions.

For people wanting to get more information on Methylene Blue from experts in the field try

Alzheimer’s Disease (AD) and Methylene Blue: Looking Into Past and Current Drug Therapies
STEM-Talk: Episode 107
Francisco Gonzalez-Lima discusses methylene blue and near-infrared light as therapies for cognitive disorders.

If anyone has other links please share.

Thank you.