Methylene Blue for Alzheimer's, Dementia, Parkinson's and UTIs

Source

Dye anyone?
But hold it is not just a dye
The first medical application of methylene blue was for malaria. In 1890,

To this day, methylene blue is found in every hospital in the world, as it’s the only known antidote for metabolic poisons (any poison that interferes with oxygen transport or displaces oxygen, either from the blood or from the mitochondria).

Moving on to Clots and brains

Perhaps one of the most revolutionary benefits of methylene blue is for the prevention and treatment of dementia, neurodegenerative diseases such as Alzheimer’s and Parkinson’s, and neural injuries caused by stroke and traumatic brain injuries (TBIs). This is particularly important as the COVID jabs have radically increased strokes. As explained by Gonzalez-Lima:

I know crankyoldman said he was going to take it.
Wonder has anyone used it, experimented with some one suffering with the ailments?

? We use Methylene Blue to treat superficial fungal infections in fish .

a reply to: puzzled2

Just don't take it in conjunction with an SSRI:

CNS toxicity involving methylene blue: the exemplar for understanding and predicting drug interactions that precipitate serotonin toxicity - PubMed

a reply to: chr0naut

Just don't take it in conjunction with an SSRI:

If I had a quarter for every time I've heard that warning I'd be moderately wealthy but not Rich

originally posted by: asabuvsobelow
a reply to: chr0naut

Just don't take it in conjunction with an SSRI:

If I had a quarter for every time I've heard that warning I'd be moderately wealthy but not Rich

Then go ahead and take both together..SMMFH

Could be a cool name for a band or a line in a lyric.

originally posted by: midicon

Could be a cool name for a band or a line in a lyric.

Reminds me of Breaking Bad

originally posted by: asabuvsobelow
a reply to: chr0naut

Just don't take it in conjunction with an SSRI:

If I had a quarter for every time I've heard that warning I'd be moderately wealthy but not Rich

Seth down, and relax already.
Hey isn't Methylene Blue in that same mystic class of products like Aniline and Dicyanin where it can be used for common things but also has a weird culty use?

originally posted by: Ravenwatcher
? We use Methylene Blue to treat superficial fungal infections in fish .

Why that's just fish paste. hee haw, that's for fiiishes not for peeoples gosh!

a reply to: puzzled2

Interesting read puzzled2 S&F

a reply to: chr0naut

Well thanks for the inspiring negativity as always. Perhaps read the article first.

“With respect to the warning about the SSRIs, the problem is not methylene blue but the amount of SSRI. The problem was in a specific application of methylene blue where they use it for parathyroid surgery as a stain ...

To my knowledge, there’s never been more than five cases, where the patients were anesthetized, and they still had SSRIs [in their system], and they did repeated flushing in the open neck with methylene blue, which exceeded these doses that we have been talking about.

The U.S. FDA reacted with this warning. But this has been reviewed by both surgeons and pharmacologists at the Mayo Clinic, and they wrote a rebuttal paper where they indicate that there is no evidence to suggest oral methylene blue has any interaction with the therapeutic dosing of serotonergic compounds, especially SSRIs, and that this was something that happened under these specific [surgical] conditions.

Canada limits the warning to that particular application, but our FDA went beyond that to any kind of serotonergic drug. I think there is absolutely no evidence for oral methylene blue having interactions in this low-dose range with any SSRIs.

And when they talk about the MAO inhibitor function, it really only works as an MAO inhibitor in the higher concentration of the higher dose range, not the low-dose range. So, the effects of methylene blue as an antidepressant — only to a very limited extent, if you repeat it cumulative treatments — can be due to any kind of a MAO inhibitor role.

In addition, it is due to its metabolic enhancing function, so it antagonizes some of the depression symptoms like the low energy that is experienced with depression. So yes, it is effective to reduce symptoms of depression. Unfortunately, this warning is going to make some physicians scared of using it in combination with SSRIs.”

originally posted by: puzzled2
a reply to: chr0naut

Well thanks for the inspiring negativity as always. Perhaps read the article first.

“With respect to the warning about the SSRIs, the problem is not methylene blue but the amount of SSRI. The problem was in a specific application of methylene blue where they use it for parathyroid surgery as a stain ...

To my knowledge, there’s never been more than five cases, where the patients were anesthetized, and they still had SSRIs [in their system], and they did repeated flushing in the open neck with methylene blue, which exceeded these doses that we have been talking about.

The U.S. FDA reacted with this warning. But this has been reviewed by both surgeons and pharmacologists at the Mayo Clinic, and they wrote a rebuttal paper where they indicate that there is no evidence to suggest oral methylene blue has any interaction with the therapeutic dosing of serotonergic compounds, especially SSRIs, and that this was something that happened under these specific [surgical] conditions.

Canada limits the warning to that particular application, but our FDA went beyond that to any kind of serotonergic drug. I think there is absolutely no evidence for oral methylene blue having interactions in this low-dose range with any SSRIs.

And when they talk about the MAO inhibitor function, it really only works as an MAO inhibitor in the higher concentration of the higher dose range, not the low-dose range. So, the effects of methylene blue as an antidepressant — only to a very limited extent, if you repeat it cumulative treatments — can be due to any kind of a MAO inhibitor role.

In addition, it is due to its metabolic enhancing function, so it antagonizes some of the depression symptoms like the low energy that is experienced with depression. So yes, it is effective to reduce symptoms of depression. Unfortunately, this warning is going to make some physicians scared of using it in combination with SSRIs.”

In the 4th paragraph that you quoted, it says "there is absolutely no evidence for oral methylene blue having interactions in this low-dose range with any SSRIs." (my emphasis added for clarity) - Of course there is no evidence of such because methylene blue is usually administered intravenously, especially in treatment of blood conditions, such as clotting, and in the treatment of Alzheimers. The article suggesting that interactions with SSRI's is overblown, is purposefully misleading.

Here's the entry on Methylene Blue at drugs.com

Methylene blue From Wikipedia, the free encyclopedia

Methylene blue | C16H18ClN3S - PubChem

It is only prudent that one be cautious about non-mainstream and not frequently researched drugs. Definitely, I would advise that any administration of methylene blue be done under medical supervision and close observation. If it were to prove effective, then every rigorously observed trial would add to our knowledge and experience of its use. Self administration of the chemical "off the books" adds nothing to the overall scientific and medical knowledge of the substance, as well as potentially having severe adverse effects which may be misunderstood and mistreated by medical staff in the case of a bad reaction.

a reply to: chr0naut

So strange you express caution for this, but advocate for mass injection of a weakly tested substance, that has a formula that changes at the will of the producers and not tested.

Perhaps the problem you have is with the lack of profit not the lack of benefit.

Is this the reason you're so negative?

Key findings
The present study indicated the ability of MeBlu to suppress the interaction between SARS‐CoV‐2 S protein and hACE2. Importantly, researchers reported that this dye can inhibit the SARS-CoV-2 Delta strain, which has been categorized as a variant of concern (VOC). This study reinforced the potential of the MeBlu dye compound as a cost-effective therapeutic antiviral treatment for SARS-CoV-2 infection.

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

originally posted by: vonclod

originally posted by: asabuvsobelow
a reply to: chr0naut

Just don't take it in conjunction with an SSRI:

If I had a quarter for every time I've heard that warning I'd be moderately wealthy but not Rich

Then go ahead and take both together..SMMFH

you misunderstand .

I'm simply pointing out the Comical amount of drugs that are stamped " Don't take with SSRI's " , I'm not saying is untrue,

a reply to: chr0naut

First off, I think we can all agree that something taken orally is going to have different effects to something taken intravenously. This makes your post mostly irrelevant to what puzzled was saying. You can't compare apples to oranges as much as so many like to do these days.

Secondly, had you of actually looked at ORAL MB you would see that the list of side effects is actually pretty small with no severe effects listed, also making your post mostly irrelevant.

WEBMD - Side effects

In conclusion, thread derailment to push a narrative is bad, mkay.

originally posted by: asabuvsobelow

originally posted by: vonclod

originally posted by: asabuvsobelow
a reply to: chr0naut

Just don't take it in conjunction with an SSRI:

If I had a quarter for every time I've heard that warning I'd be moderately wealthy but not Rich

Then go ahead and take both together..SMMFH

you misunderstand .

I'm simply pointing out the Comical amount of drugs that are stamped " Don't take with SSRI's " , I'm not saying is untrue,

Ok, my apologies

originally posted by: puzzled2
a reply to: chr0naut

So strange you express caution for this, but advocate for mass injection of a weakly tested substance, that has a formula that changes at the will of the producers and not tested.

At 11.2 billion doses administered now, and with 2 years of clinical data, I would think it is one of the best tested medicines in human history.

Perhaps the problem you have is with the lack of profit not the lack of benefit.

Is this the reason you're so negative?

Key findings
The present study indicated the ability of MeBlu to suppress the interaction between SARS‐CoV‐2 S protein and hACE2. Importantly, researchers reported that this dye can inhibit the SARS-CoV-2 Delta strain, which has been categorized as a variant of concern (VOC). This study reinforced the potential of the MeBlu dye compound as a cost-effective therapeutic antiviral treatment for SARS-CoV-2 infection.

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

I don't make any money from any pharmacology, or from any company involved in the direct manufacture of pharmacological products.

I was just pointing out that there are warnings against certain drug interactions made by credible people.

The article quoted from papers that purely researched injected methylene blue, and wrote off legitimate warnings by talking about the relative safety of orally administered methylene blue.

a reply to: chr0naut

At 11.2 billion doses administered now, and with 2 years of clinical data, I would think it is one of the best tested medicines in human history.

I would almost agree aside from one thing .

Why the hold out on releasing the overall findings and Data of the Vaccine and it's effects ?

originally posted by: puzzled2
Source

Dye anyone?
But hold it is not just a dye
The first medical application of methylene blue was for malaria. In 1890,

To this day, methylene blue is found in every hospital in the world, as it’s the only known antidote for metabolic poisons (any poison that interferes with oxygen transport or displaces oxygen, either from the blood or from the mitochondria).

Moving on to Clots and brains

Perhaps one of the most revolutionary benefits of methylene blue is for the prevention and treatment of dementia, neurodegenerative diseases such as Alzheimer’s and Parkinson’s, and neural injuries caused by stroke and traumatic brain injuries (TBIs). This is particularly important as the COVID jabs have radically increased strokes. As explained by Gonzalez-Lima:

I know crankyoldman said he was going to take it.
Wonder has anyone used it, experimented with some one suffering with the ailments?

wow, quite the call back PZ.

I have tried for a month or so. I had no particular ailments, but it was fun to experiment with. It was harmless to me, except for the staining. Don't spill and brush teeth fast. I did like the feeling very much, the "blue" for me was more along the light spectrum, sort of like wearing "blue glasses" or "rose colored shades" if you will, as the color entered the cells in the body. That was very pleasant.

There are three sorts of people. Those who know enough about themselves and their body to try new things based on research and intuition. Those who are in the fence and those who only follow dogma and fear most things. If you fall into the first category I say research. Amazon has the recommended brand, powder just add purified water. And watch the staining.

I do agree with the article you posted, a small amount is probably better then a large amount, it seems one of those types of things where a little goes a long way.