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originally posted by: whereislogic
a reply to: bladerunner44
...
I've had another look at the proposed mechanisms of Ivermectin, which is not nearly as well researched and tested as HCQ; also because it's harder to test for if you look at the details of these theorized MOA's, you're much more dependent if the theorizing being done is realistic and accurate from the perspective of biochemistry, with HCQ it directly affects viral loads in the cell, which you can test and verify both in vitro and in vivo, as has been done. This video proposes 4 MOA's, I get the impression that none of these have been verified:
Also, none of the MOA's proposed there are supported with a link to a study specifically about testing that MOA (unless I didn't pay attention). They may make perfect sense, and it may very well be that it works that way, but can you take a large enough dosage of ivermectin to have a significant enough effect for all 4 proposed MOA's, or any one of them specifically?
...followed by the addition of 5 μM ivermectin.
And I will be clear about what that implies, is that they didn't reach anywhere near 5 micromolar, or even 2 micromolar in every cell. Which they won't spell out there, but they know. That is what I call dishonest, giving a false impression that this study has relevance and is promising, " worthy of further consideration", as they put it at the end of section "1. Introduction." They won't go further into that subject in the other sections of the article either (since that's what they've been taught how to construct their papers and make them appear as valuable research, as if it's not important to use realistic dosages to get further funding to investigate further into how much micromolar can be achieved realistically in vivo in humans with reasonable dosages).
As noted, ivermectin was the focus of a recent phase III clinical trial in dengue patients in Thailand, in which a single daily dose was found to be safe but did not produce any clinical benefit.
Caly et al.1 reported that ivermectin inhibited severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in vitro for up to 48 hours using ivermectin at 5 μM. The concentration resulting in 50% inhibition (IC50 ; 2 µM) was > 35× higher than the maximum plasma concentration (Cmax ) after oral administration of the approved dose of ivermectin when given fasted. Simulations were conducted using an available population pharmacokinetic model to predict total (bound and unbound) and unbound plasma concentration-time profiles after a single and repeat fasted administration of the approved dose of ivermectin (200 μg/kg), 60 mg, and 120 mg. Plasma total Cmax was determined and then multiplied by the lung:plasma ratio reported in cattle to predict the lung Cmax after administration of each single dose. Plasma ivermectin concentrations of total (bound and unbound) and unbound concentrations do not reach the IC50 , even for a dose level 10× higher than the approved dose. [whereislogic: they can't even reach 2 micromolar without going 10x higher than the approved dosage; it's not like the writers of that other study, or the Whiteboard Doctor doesn't know this, they conveniently left that out, see article in my signature about the habit of leaving out inconvenient facts, cherry-picking only the useful facts to use to sell your propaganda. And we're talking about the 50% effect, not even the 99.99% effect bragged about as if it's really significant.] Even with the high lung:plasma ratio, ivermectin is unlikely to reach the IC50 in the lungs after single oral administration of the approved dose (predicted lung: 0.0873 µM) or at doses 10× higher that the approved dose administered orally (predicted lung: 0.820 µM). In summary, the likelihood of a successful clinical trial using the approved dose of ivermectin is low. Combination therapy should be evaluated in vitro. Repurposing drugs for use in coronavirus disease 2019 (COVID-19) treatment is an ideal strategy but is only feasible when product safety has been established and experiments of repurposed drugs are conducted at clinically relevant concentrations.
originally posted by: whereislogic
...
edit: The in vitro study in question is this one:
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro - ScienceDirect
... A randomized, double-blind, placebo-controlled trial was conducted...
... oral ivermectin alone (12 mg once daily for 5 days), oral ivermectin in combination with doxycycline (12 mg ivermectin single dose and 200 mg doxycycline on day 1, followed by 100 mg every 12 h for the next 4 days)and a placebo control group.
... Clinical symptoms of fever, cough, and sore throat were comparable among the three groups. ...
Virological clearance was earlier in the 5-day ivermectin treatment arm when compared to the placebo group (9.7 days vs 12.7 days; p = 0.02), but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27).
A 5-day course of ivermectin was found to be safe and effective in treating adult patients with mild COVID-19. Larger trials will be needed to confirm these preliminary findings.
One patient from each of the ivermectin + doxycycline and placebo groups and two patients in the 5-day ivermectin group withdrew their consent during the study due to family obligations and unwillingness to be tested further.
originally posted by: angelchemuel
And almost 2 years later.....they still say they have not isolated the virus...... but they have a jab based on the protein encapsulation.....
Rainbows
Jane
Accept that the virus has been isolated many times.
fullfact.org...
You are obviously new to the forum op. Everyone already knows all this, it's been discussed so many times it's getting very boring now.
SARS was beat pretty easily without vaccine. Polio was beaten with water sanitation. Smallpox was beaten because of very visible symptoms and social distancing.
Where are you at? Don't have to say the hospital but just curious like what region of the states or what state? I'm on the business side of Healthcare and in our 13+ major hospitals across the midwest that is not what we are seeing. 83% of the hospitalizations are unvaccinated, unless of course that is one big lie which I can't truly validate.
Correct but the reason why the Polio vaccine has worked is because in the US we have roughly 92% of anyone over the age of 2 vaccinated for. The vaccine brings the r value down (replication rate) in an infectious disease.
The r value for Polio is roughly between 4-6 which means, we'll just use 5 as the value, that if you have 80% of people vaccinated for Polio you will not have any huge outbreaks and will have "control" over it.
(1/r-value) take this number and then subtract it from 1 then you take that x 100 to get your recommended vaccine %
Are you, by any chance, pushing this product for any selfish motive?
Sounds like marketing push to me.
originally posted by: CupcakeKarma
a reply to: andy06shake
andy06shake
Oh... and this from the CDC, “On June 7, 2021, the CDC confirmed (again) in writing they do not have any records showing they have ever isolated or purified the virus that allegedly causes the disease called COVID-19.”
It turns out that washing your hands, wearing a mask and socially distancing are all really good ways of avoiding catching the flu.
originally posted by: CupcakeKarma
a reply to: AaarghZombies
It turns out that washing your hands, wearing a mask and socially distancing are all really good ways of avoiding catching the flu.
AaarghZombies
I think even MORE important is one’s health. A person in POOR health and eating for 5 will NOT fare with ANY disease, cold, virus, [… fill in blank …] as well as a person who works hard to maintain a healthy lifestyle and diet.
I also use hard statistics to debunk various myths about covid and the vax.
For example, I constantly post links demonstrating how very few double vaxxed people get sick or die from Covid, and how the majority of those who are seriously sick are completely unvaxxed.
Like how in 6 months only 640 double vaxxed people died due to Covid in the UK, while at the same time 38,000 unvaxxed died due to covid. That's some disparity, isn't it.
Source
Source
Source
Source
Source
Source
Anti-vaxxers just hate it when people say that they will "do their own research" and then come across one of my posts, and decide that they will get the vax after all.
Lockdowns will do that, too.
originally posted by: CupcakeKarma
a reply to: AaarghZombies
I also use hard statistics to debunk various myths about covid and the vax.
For example, I constantly post links demonstrating how very few double vaxxed people get sick or die from Covid, and how the majority of those who are seriously sick are completely unvaxxed.
Like how in 6 months only 640 double vaxxed people died due to Covid in the UK, while at the same time 38,000 unvaxxed died due to covid. That's some disparity, isn't it.
Source
Source
Source
Source
Source
Source
Anti-vaxxers just hate it when people say that they will "do their own research" and then come across one of my posts, and decide that they will get the vax after all.
AaarghZombies
Statistics are not my current favorite source of evidence because they can be used so easily with clever wording… and I will show YOU why YOUR sources have omitted a KEY point…
The sources you provided, are claiming that being vaccinated relies upon a key word… FULLY FACCINATED.
Meaning… if one has had o vaccine within perhaps the previous 14 days period… that person is considered as UNvaccinated. A LIE
AND… if one has had a vaccine and not a second or third of 50th dose… that person is considered as UNvaccinated. A LIE
NO… try again… NEXT time… let’s see some statistics that include REAL UNVACCINATED people… not pretend ones.
originally posted by: CupcakeKarma
a reply to: Oldcarpy2
Lockdowns will do that, too.
Oldcarpy2
The FORCED and ILLEGAL lockdowns have contributed to suicide.... but i guess THOSE deaths don't count, eh?
Kind of like the gov of the state of Maine who was BEGGED by the hospitals to NOT enforce the covid vax mandate or they would lose so many personnel, they may shut down and/or people will not receive adequate health care.
THAT gov does not REALLY care about health or saving lives.... he blandly stated he would still enforce the [[illegal]] vaccine mandate.... and obviously, without regard to how many lives it will affect adversely.
Another situation that indicates the FORCED toxic vax is about CONTROL... NOT health.