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originally posted by: TheAMEDDDoc
a reply to: ChaoticOrder
... I don’t know why people are having so many issues with this.
The image of scientists as invariably dedicated to truth has been tarnished, as these headlined items show.
“Ethics in Science”
“A fight is building in the U.S. House of Representatives over fraud, misconduct, and conflict of interest in science.”—Science, July 7, 1989.
“Do Scientists Cheat?”
“After the initial inquiry by this [congressional] committee into this subject, the committee has had growing reason to believe that we are only seeing the tip of a very unfortunate, dangerous, and important iceberg.”—NOVA broadcast on PBS (Public Broadcasting Service) on October 25, 1988.
“Two New Studies Ask Why Scientists Cheat”
“It was an innocent enough question: how do scientists behave when no one is looking? But it has produced an incendiary answer: not too well, reports a paper this month in the British journal Nature.”—Newsweek, February 2, 1987.
“A Nation of Liars? Scientists Falsify Research”
“A study published last month accused 47 scientists at the Harvard and Emory University medical schools of producing misleading papers.”—U.S.News & World Report, February 23, 1987.
“NIH Sees Plagiarism in Vision Paper”
“Panel says researcher took data from paper he peer-reviewed and used it for his own work; . . . NIH [National Institutes of Health] recommends debarment proceedings.”—Science, July 14, 1989.
“‘Permissive Behaviour’ Breeds Fraud in the Laboratory”
“Biomedical scientists in America are performing sloppy and sometimes fraudulent research in an effort to publish more papers and make more money.”—New Scientist, February 25, 1989.
“Researchers Roll Back the Frontiers of Fraud”
“Scientific fraud and carelessness among researchers could be widespread, warns a study in last week’s issue of Nature.”—New Scientist, January 22, 1987.
“Researcher Accused of Plagiarism Resigns”
“A biochemist accused of plagiarizing a National Academy of Sciences report for a book on nutrition and cancer resigned from his position at the Cleveland Clinic Foundation.”—Science, September 4, 1987.
“The Pill: Professor’s Safety Tests Were Faked”
“His deception puts a question mark over safety checks on pills being taken by up to 2 m[illion] women in Britain and 10 m[illion] worldwide.”—The Sunday Times, September 28, 1986.
“Senior Drugs Researcher Resigns in Disgrace”
“He resigned last week after an independent committee of inquiry found him guilty of scientific fraud.”—New Scientist, November 12, 1988.
“NIMH Finds a Case of ‘Serious Misconduct’”
“A surprisingly long-running, flagrant and deliberate case of scientific fraud according to a draft report of an investigation conducted for the National Institute of Mental Health.”—Science, March 27, 1987.
“Research ‘Fraud’ Puts Poison Into the Ivy League”
“A prominent Bostonian psychiatrist resigned as head of a mental hospital affiliated to Harvard University, following charges of plagiarism.”—New Scientist, December 10, 1988.
“The Case of the ‘Misplaced’ Fossils”
“A prominent Australian scientist has examined two decades of work on ancient Himalayan geology and alleges it may be the greatest paleontological fraud of all time.”—Science, April 21, 1989.
“Now It’s the Journals’ Turn on the Firing Line”
“[He was speaking] specifically about how poorly many [science] journals have handled scientific fraud. . . . The same message previously dispatched to other members of the scientific community has now been addressed to the journals: clean up your act or you may find legislators getting into it.”—The AAAS Observer, July 7, 1989.
...
A senior editor at The Journal of the American Medical Association, Dr. Drummond Rennie, commented on the lack of quality: “There seems to be no study too fragmented, no hypothesis too trivial, no literature citation too biased or too egotistical, no design too warped, no methodology too bungled, no presentation of results too inaccurate, too obscure, and too contradictory, no analysis too self-serving, no argument too circular, no conclusions too trifling or too unjustified, and no grammar and syntax too offensive for a paper to end up in print.”
...
“For high-octane gall in proclaiming its ethical purity, the scientific community has long been the runaway winner,” said New Scientist magazine. The highly vaunted peer-review system that theoretically screens out all the cheats is felt by many to be a farce. “The reality,” New Scientist said, “is that few scientific scoundrels are caught, but, when they are, they frequently turn out to have been running wild for years, publishing faked data in respectable journals, with no questions asked.”
Previously, an official of the NIH said, as reported in The New York Times: “I think an age of innocence has ended. In the past people assumed that scientists didn’t do this kind of thing. But people are beginning to realize that scientists are not morally superior to anybody else.” The Times report added: “Although a few years ago it was rare for the National Institutes of Health to receive one complaint a year of alleged fraud, she said, there are now at least two serious allegations a month.” Science magazine observed: “Scientists have repeatedly assured the public that fraud and misconduct in research are rare . . . And yet, significant cases seem to keep cropping up.”
The chairman of one of the congressional investigating committees, John Dingell, at one time said to scientists: “I will tell you that I find your enforcement mechanisms are hopelessly inadequate and that rascality seems to be triumphing over virtue in many incidences in a fashion that I find totally unacceptable. I hope you do too.”
The NOVA program on “Do Scientists Cheat?” concluded with this acknowledgment by one of the scientists present: “Skeletons have to come out of the closets, bureaucrats’ careers have to be impaired if that’s what it takes, and there’s no alternative. This is ethically required, this is legally required, and it’s certainly morally required.”
originally posted by: ChaoticOrder
a reply to: ketsuko
The data from the early studies is fairly convincing, but could certainly be manipulated. However I think it's more probable that newer strains of Covid-19 have evolved some method of getting around the vaccines. Not sure if the spike protein changed, but flu viruses require a new vaccine each year and I doubt they totally change. So even if we've seen a very similar virus before it can still cause issues.
I think that maybe you're a little confused. Or that you are trying to confuse other people in order to scare them into not taking the vax.
The vax doesn't lower your immune system.
It is designed so that certain components won't be recognized as being hostile by your body so that they won't be attacked and destroyed before the mRNA is delivered.
The question is not whether it lowers immunity; it is how much it lowers immunity.
A temporary dip in immunity might be allowable provided you are forewarned and can take reasonable precautions, but those precautions become less reasonable the longer you are expected to maintain them.
originally posted by: TheRedneck
a reply to: ChaoticOrder
I'll try to simplify some.
You're referring, it seems, to the early tests on mRNA technology. The vaccine works this way:The process is actually pretty sound. I was skeptical at first, but the more I read up on the technology, the more assured I was that it is safe.
- Scientists analyze a specific protein that will, if neutralized by antibodies, disable the virus. In this case, that protein is the spike protein.
- Scientists then design an mRNA molecule to create that specific protein.
- The mRNA molecules are then wrapped in a "cocoon" of lipids, or fat molecules.
- The lipids are suspended in a solution as a vaccine. It has to be kept refrigerated because the lipids will degrade rapidly at room temperature.
- In the body, cells see these lipids as food and absorb them, also absorbing the mRNA.
- The lipids are digested in the cell, leaving the mRNA molecule.
- The mRNA molecule then instructs the cell to produce the spike protein. The cell cannot distinguish it from internal mRNA produced by the nucleus and DNA; it simply recognizes that it is mRNA.*
- The mRNA is destroyed in the process.
- The spike proteins, since they are not native to the cell, migrate to the cellular membrane.
- The innate immune system then recognizes the spike protein as a foreign body and begin to create antibodies to attack it.
- Once sufficient antibodies are made (that's the two weeks you mention), the person has antibodies against the virus that carries the spike protein.
However, remember that all this is based on one thing: making the right protein. Make the wrong protein, and not only will the vaccine be ineffective but it could actually damage the body's internal mechanisms. Sort of like putting gasoline in a diesel motor... yeah, it's still liquid hydrocarbon fuel, but when you try to crank the motor it blows itself apart. Put diesel in a gasoline motor and it just gums everything up and the motor can't start.
That's my major concern: is the spike protein safe? The virus exhibits some clotting issues similar (but more pronounced) when it enters the bloodstream, generally through damaged lung tissue. So I see the possibility that the clotting issues are caused directly by the spike protein. Now that also means that it is far preferable to take the vaccine rather than have the virus in one's bloodstream; the protein does not replicate, but the virus does. However, preferable to that would be to not have either in one's bloodstream by (hopefully) never getting a case severe enough to cause bleeding in the lungs.
More than likely the early tests you mention had errors in the manufacture or identification of the target protein. It's pretty hard for us to actually manufacture molecules like that precisely. It is cutting edge technology today; ten years ago it was still science fiction that had some scientists trying it.
* A lot of what TheAMEDDDoc is explaining is the chemical mechanism that the cells use to identify the mRNA molecule as an mRNA molecule. The poly(A) tail is one of the identifiers and the references to "5'" and "3'" are referring to the different ends of the molecule, also important. That part of the science is quite complicated and thus hard to put into layman's terms. Even I have some difficulty with the terminology, but I was able to understand some of it without wearing out a medical dictionary.
TheRedneck
The spike proteins, since they are not native to the cell, migrate to the cellular membrane.
The innate immune system then recognizes the spike protein as a foreign body and begin to create antibodies to attack it.
That's my major concern: is the spike protein safe? The virus exhibits some clotting issues similar (but more pronounced) when it enters the bloodstream, generally through damaged lung tissue.
originally posted by: ketsuko
Flu vaccines are different though. They still are made using the old method. So one strain of flu is still different from another. It has to be in order to keep coming back and infecting us year after year.
originally posted by: TheRedneck
a reply to: AaarghZombies
I think that maybe you're a little confused. Or that you are trying to confuse other people in order to scare them into not taking the vax.
You know, statements like that just grind on my nerves. Who exactly do you think you are? Do you have some innate God-like intuition that allows you to sense the intentions of others?
Or maybe, you are part of the reason so many are refusing to take the damn vaccine. I got news for ya... even in the middle of a heart attack, on the way to emergency surgery, I was still asking questions and expecting answers. I am DAMN sure going to ask questions about what I am allowing into my body now!
If no one gets to ask questions, no one, period, should be taking this shot.
The vax doesn't lower your immune system.
Prove it. I have never met a medicine of any kind that doesn't affect immunity in some way. The question is not whether it lowers immunity; it is how much it lowers immunity.
It is designed so that certain components won't be recognized as being hostile by your body so that they won't be attacked and destroyed before the mRNA is delivered.
Yeah, it's called being embedded in a lipid. The cells absorb the lipids for food and get the mRNA as a bonus.
But why answer questions? If asking questions means someone is trying to "scare others," isn't answering them doing the opposite and trying to ram this thing down people's throats?
YOU are one of the reasons why I refuse to get the vaccine. What's in it for you, anyway? What benefit does it do you if someone else gets the vaccine or not? That's the question I want to see answered.
TheRedneck
You want to know who I am, well, I'm an old hand at this game, that's who I am.
People are refusing to take the vaccine because people like you are needling them every 5 minutes to put doubt into their mind.
The vax doesn't lower your immune system because that would just be stupid. It's entire purpose is to elicited an immune response. If it lowered your defenses it would be self defeating.
It's all well and good asking questions, but you're doing it deliberately to cause fear.
When unvaxxed people get sick my freedoms get restricted.