This is why I fear mRNA vaccines.

originally posted by: chr0naut

Placido Domingo was a tenor (neither a ten pound note, nor a vaccine)?

Thanks for the correction as it wasn't like I misspelled it and didn't look close enough...lol...

originally posted by: Violater1

originally posted by: Phage
a reply to: Violater1

How do you think it gets from the muscle injection to the cell's nucleus?

It doesn't enter the nucleus of the cell. It causes ribosomes (which are not in the nucleus) to produce the spike protein. Antibodies which destroy the spike protein are then produced. Those antibodies are then released into the bloodstream to go hunting.

mk0lcfamerica27gkeby.kinstacdn.com...

I'm sure you will find many liberal sites that will follow your agenda.
Here is just one site scholastic site that does not follow any political agenda, and again, proves you wrong.

www.pnas.org...

I will not attempt to correct you anymore, so carry on with your agenda elsewhere.

That paper says nothing about mRNA entering the nucleus. It's about the transport of mRNA inside the nucleus, where it's produced, and the eventual transport from inside the nucleus into the cytoplasm.

Get the shot, don’t get the shot, wear a mask, don’t wear a mask, pretty simple, the anti vaxers are not going to change a Vaxers mind, an anti masker isn’t going to change a maskers mind, it’s just another circle jerk they have us in. a reply to: Violater1

originally posted by: Joefoster
Get the shot, don’t get the shot, wear a mask, don’t wear a mask, pretty simple, the anti vaxers are not going to change a Vaxers mind, an anti masker isn’t going to change a maskers mind, it’s just another circle jerk they have us in. a reply to: Violater1

I guess I'm not seeing things in such a binary, black/white fashion.

I believe in the value of vaccines, the (time-tested and proven) science behind them.

I have personally been fully vaccinated my entire life, every required vaccine every step of the way.
My children have been fully vaccinated their entire lives, every required vaccine every step of the way.

Mind you, this included inoculation against things like measles, mumps, rubella, small pox, and the vaccines for these illnesses are all many decades old now, and they have involved a particular form of administration, either as an inactive (dead) copy of the virus or live/"attenuated" form of the virus. We have been doing things this way going on 70 years now.

The two compelling points in the context of COVID that give people pause:

* why are vaccinations being pushed (many think we are on the eve of compulsory COVID vaccination and COVID "passports" to engage in normal public activity) even for healthy segments of the population for which COVID has been shown to be survivable 99%+ of the time?

* why have the vaccines for COVID switched to this new, human un-tested, novel mRNA "programmed protein" approach rather than used what's worked (administration of inactive or attenuated virus) and shown to work with a proven history of neglible adverse reaction and side effects?

a reply to: Violater1

Just because there is a longtime of testing a new vaccine before it can be given to humans gives me the feel that the specialist do not exactly understand how it works...but have a good idea of what they are creating. Just like messing with genetically modified organisms. The long term side effects will show...or not..

Reading the OP a person can say that vaccines are serious medicine and should only be taken if there is no other solution. Then there is the chance that the covid virus will mutate into a previous vaccine resistant virus. What will happen if a person will take an other vaccine...and an other for the next mutated virus? If you ask me this will increase the risc of serious damage to the immune system.

a reply to: SleeperHasAwakened
I have heard that the virus has not been isolated........not sure if it's true.
Maybe someone will post a link saying that it has.

a reply to: Phage

But, aren't these ribosomes within the mitochondrial DNA?

(Really...I'm just trying to wade through all the information, disinformation, and misinformation to understand what's what.)

Wondering if we've got a few here working as J&J spokesmen or maybe they're GMO specialists to tell us what to do with our own bodies because, somehow "God" didn't create us right and we need help from billion dollar companies to fix it..

Who trusts them, if so why, and if yes, do these companies pushing injections get some kind of monetary return for their sacrifices?

Don't these jabs void insurance?

Questions... questions.....

Rep. Jim Jordan
@Jim_Jordan

Apr 19
How many masks are we supposed to wear this week?

ksorbs

a reply to: queenofswords

But, aren't these ribosomes within the mitochondrial DNA?

No. Ribosomes, like mitochondria, are "organelles". Separate things which exist in the cytoplasm and perform different cellular functions.
The Cell

Nothing is "within" DNA, DNA is within the nucleus of the cell (and within the mitochondria).

a reply to: Phage

Isn't mitochondrial DNA where mRNA begins the process? From there, doesn't it then begin the next phase to instruct the ribosomes what protein to make?

I'm not talking about the DNA in the nucleus, but rather the mitochondrial DNA within mitochondria and pertaining to this particular protein manufacture.

Doesn't the mRNA have to get its instructions first from the mtDNA (in this case)?

If so, why mtDNA rather than nuclear DNA?

(Still attempting to follow the information, disinformation, and misinformation.)

a reply to: queenofswords

Isn't mitochondrial DNA where mRNA begins the process?

No. As I said, the mRNA from the vaccine does not enter the mitochondria. It does not interact with any DNA (nuclear or mitochondrial). The formation of the spike protein is performed by ribosomes.

Doesn't the mRNA have to get its instructions first from the mtDNA (in this case)?

The mRNA is the instructions. It is artificially constructed. When it is injected and enters the cell it causes the ribosomes to produce the spike protein.

a reply to: Phage

When it is injected

"It" being an artificial/synthetic messenger sent via injection into the arm muscle to "talk" to your cells and issue the instructions on how to manufacture the S protein?

Proteins are manufactured within the cytoplasm...correct? They are manufactured by ribosomes...correct?

Mitochondria has its own ribosomes...correct?

Are the ribosomes that produce the spike protein the ones from the mitochondria?

a reply to: queenofswords

"It" being an artificial/synthetic messenger sent via injection into the arm muscle to "talk" to your cells and issue the instructions on how to manufacture the S protein?

Yes.

Mitochondria has its own ribosomes...correct?

Yes. (It's interesting that mitochondrial ribosomes are more like bacterial ribosomes than they are eukaryotic ribosomes.)

Are the ribosomes that produce the spike protein the ones from the mitochondria?

No. Mitochondrial ribosomes are within the mitochondria, they are not in the cytoplasm. The mRNA does not enter the mitochondria.

Mitochondrion

originally posted by: KansasGirl
Again- they are not approved in the US.

Correction - these genejabs have EUA (emergency use authorization) only.

My understanding is, there have been no long term trials for side effects, and there have been ZERO animal safety trials. My understanding is also that without both of these - long term safety trials, and animal safety trials - they can not legally be approved in the same manner as actual vaccines.

If this is true, then anyone who claims they are 'fully tested is lying (whether knowingly or not).

Also, all earlier animal safety trials for mRNA genejabs resulted in the deaths of all of the test animals when they were exposed to the actual live virus.

The bottom line is, if someone believes it works, they are welcome to it, and if they really actually do believe it, they should be fine with anyone who chooses not to get it, because, if it works, then they have nothing to fear from the unvaccinated.

a reply to: tanstaafl

Also, all earlier animal safety trials for mRNA genejabs resulted in the deaths of all of the test animals when they were exposed to the actual live virus.

I would really like to see a source for this claim. It sounds very concerning. Can you at least tell me which trials which are being talked about?

a reply to: Phage

I heard about this yesterday,I'll look for the article
that I read.

This thread is entertainment at its best.. people who obviously have no idea what they are talking about trying to interpret and mold the work of scientists to suit their pre-determined viewpoints on the mRNA technology.

Reminds me a of a meeting of cavemen arguing that fire is a bad idea because it can also burn you...

a reply to: Phage

It happened early on in mRNA research, the problem was they didn’t initially target the spike, with coronavirus at least. They focused on other proteins and the hosts had issues producing reliable antibodies to neutralize the virus. The result was non neutralizing antibodies that helped the virus enter cells while still being functional when they were challenged after vaccination. Antibody mediated entry, causes some nasty problems because instead of ACE2 or maybe CD209 or whatever other receptors the virus primarily uses didn’t need to be used anymore. The antibodies helped the virus enter additional tissue types and the animals responded with an inflammatory crisis that ended up killing them. This was decades ago though.

Now that they switched their target to a more stable area, it’s not really an issue with most strains out there. Although, I am curious about some of the Indian strains with their escape mutations they developed in response to possibly more efficient immune responses. It’s going to happen, respiratory viruses will always bind cells, no matter what, even in the vaccinated. Mutations will happen, usually they aren’t useful and the original strain will still outcompete the new strains in the body or it’s not enough to evade antibodies and cell mediated responses. It’s when these new strains are able to evade the immune response and out compete the original strain that it becomes a problem.

a reply to: queenofswords

They’re actually two separate systems. Mitochondria as an organelle evolved from an ancient eukaryotic cell taking in a bacteria and developing a symbiotic relationship rather than just eating the thing as the environment changed on earth.

So they have some remaining DNA, mostly circular like a bacteria, and that mainly contributes to processing of pyruvate. Their ribosomes are less sensitive, allow more wobble, and are still more similar to the original bacteria. Pyruvate is a result of glycolysis which is the ancient way of producing energy, the mitochondrial expand this exponentially to produce even more energy. So their ribosomes and DNA mostly contributes to the electron transport chain and complexes that produce more energy from pyruvate/acetylCoA in the TCA cycle.

Ribosomes in the cytoplasm come from a ribosome factory called the nucleolus which is in the nucleus. They process mRNA from the nucleus.

An interesting hypothesis that is gaining attention is that mitochondrial DNA is sensitive to changes. Many cells and tissues may express different genes (from mutations) with some being abnormal and those may contribute to metabolic, neurological, and musculoskeletal diseases that appear later in life. Basically, even in the same cell, some mitochondria could be normal and others abnormal, and this gets amplified under inflammatory and oxidative stress as we age, even contributing to the aging process.