This is why I fear mRNA vaccines.

originally posted by: Phage
a reply to: Violater1

How do you think it gets from the muscle injection to the cell's nucleus?

It doesn't enter the nucleus of the cell. It causes ribosomes (which are not in the nucleus) to produce the spike protein. Antibodies which destroy the spike protein are then produced. Those antibodies are then released into the bloodstream to go hunting.

mk0lcfamerica27gkeby.kinstacdn.com...

Again (and again), you are wrong. (I'm beginning to enjoy this)

micro.magnet.fsu.edu...

Just stop Phage, you're embarrassing yourself.

a reply to: Violater1
Your source:

Ribosomal proteins enter the nucleolus and combine with the four rRNA strands to create the two ribosomal subunits (one small and one large) that will make up the completed ribosome (see Figure 1). The ribosome units leave the nucleus through the nuclear pores and unite once in the cytoplasm for the purpose of protein synthesis.

Ribosomes form and perform their function in the cytoplasm, not in the nucleus. mRNA vaccines do not act on the nucleus.

a reply to: Violater1

What did any of that have to do with a virus or a vaccine against it?

Macrophage
From Wikipedia, the free encyclopedia.

Yes, immune response can be dangerous if overstimulated, but even chemical irritants in our environment can trigger that. And the process of testing and approval of a vaccine means that we have a good idea of how the human immune system responds to the vaccine, before we even approve it for the general populace.

With more than 888 million shots given (Covid-19 Vaccine Tracker), I think by now that if the vaccines were significantly dangerous, we would have a pretty good idea of how, and the extent of those dangers. No amount of supposition counters the current facts.

a reply to: Violater1

Hey a doctors office poster is all you need for proof not your fancy science. /sarc

dude can't even remember which vaccine has mRNA and he thinks he knows how cells work

a reply to: Phage

You’re correct, mRNA needs a signal to get through the nuclear pore complex. So, here, we are trusting them not to include one so it does not become a transposable element, which it should not. Natural infection from coronaviruses can incorporate in those with HIV infection or overactive LINE-1 (cancers) as reverse transcriptase from HIV or the LINE-1 transposable element incorporate portions into our genome. This could be beneficial in certain immune cells but can also be a driver for cell cycle arrest, activation of DNA repair (which a retrovirus blocks), or development of cancers as transposable elements corrupt active areas of DNA in the cell and proliferation increases and glucose metabolism changes. Each cell has the same genes and just activates different ones depending on what the purpose of the cell is in the body.

The adenovirus vectors eventually produce RNA but exist as a DNA plasmid in the nucleus that has incorporated in animal studies but is not likely. Some people can react to the adenovirus vector, some people form clots, it is longer lasting because a DNA plasmid is longer lasting.

The mRNA vaccines should be cleared quickly, the cells presenting viral components are removed, and that’s it. There is risk of autoimmune disease but that’s usually associated with self amplifying RNA. Plasmid infected cells may last weeks, but they will still be cleared because they present another external components, viral spike proteins. So even if it incorporates, that cell should be cleared from the system.

The adaptive immune response combined with other signaling will tell the innate immune response to knock it off, if it didn’t, all that stuff happening above would have happened long long ago and most life on this planet would not exist. There would need to be some significant aberration in gene expression and immune function, as in knock in or knocking out of genes, for that to occur. Dendritic cells, other APCs and regulatory T cells etc help keep all of our systems in check along with transcription factors and activators.

Same stuff, different day, people who are either educated or partially educated in the field leave out important components to spread fear about immunology and molecular biology.

originally posted by: Phage
a reply to: Violater1

During cellular division, the J&J mRNA can reproduce,

The J&J vaccine is not an mRNA vaccine. It is a viral vector vaccine, more like a "traditional" vaccine in that it uses actual (modified) viral material.

And this again proves that mRNA comes from the nucleus of the cell.

Of course it is. Has anyone said otherwise? But with mRNA vaccines it is synthesized and injected into a muscle, it then enters the cell where it causes ribosomes to produce the spike protein.

I corrected myself, J&J Jab is not mRNA.

originally posted by: fiverx313
doesn't the mRNA dissolve though?

The mRNA is utilized in the process of building the amino acid sequence it encodes. It doesn't keep producing more and more stuff for ever. It does its job and is no more, it's chemistry becoming part of the new amino acids or it parts being discarded as wastes.

a reply to: chr0naut

I reckon that would be why more than one dose is required to produce a full immune response. The first dose gets used up.

a reply to: igloo

Here is what I don’t understand: why are people not bothered by the gag orders placed on doctors and virologists and such who are speaking out about concerns with these non-vaccines? Why are they not concerned that social media platforms censor a person if they even mention the word vaccine???

Why doesn’t that at least cause them pause? If everything is hunky dory, WHY is reporting on these things not allowed? WHY ARE QUESTIONS NOT ALLOWED! Why is big pharma so trustworthy to them all of a sudden!

What the hell!

Regarding the moral obligation piece you mentioned, I’m only talking about it with immediate family whom I love. My ex husband, my son. Fortunately the rest of my family is not going to get the “jab” (or jabS, since as many of us predicted, the number they say you need keeps going up), and my son says he doesn’t plan on taking it. But I have made my ex-hubbs pissed off at me on several occasions for reaching out to him and asking him to wait to get it or at least to think about it. He’s said some not-so-nice things to me every time, 😂 but I tell him that I would want someone to warn me even if it pissed me off, when it’s something that has such a possibility of profound effects later.

I have friends who have told me proudly about their “jab” completion, and I don’t say anything. If they asked, I would. But I don’t say “Great!” or “Good for you,” etc, I just ask them how they’re doing. This is such a fu**ing mess. 😰

a reply to: TheAMEDDDoc
Can you please provide a scholastic independent medical link that proves that the SARS-CoVID mRNA vaccine will not be duplicated in cellular division and the replication turns off. I have found none.
These two factors, are very important.

originally posted by: Violater1

originally posted by: Phage
a reply to: Violater1

The mRNA moves along to inside the nucleus of the cell

No it doesn't.

Really?
How do you think it gets from the muscle injection to the cell's nucleus?
Just go away.
www.youtube.com...

It is delivered to the cytoplasm of the cell via a delivery mechanism of a benign virus, such as an adenovirus. The current issues with possible blood clots from the AstraZeneca vaccine is due to the adenovirus used as the delivery mechanism not being as benign as previously thought.

a reply to: Violater1

I tend to agree with the no "off switch", but if that is the case and "the experts" obviously know this, why are they now pushing for boosters every 6 months? Are they just trying to really make sure that the sheep taking this experimental shot are doomed into a nasty downspiral of miserable slow death?

originally posted by: Xtrozero
I wonder what kind of butterfly I will become when I emerge from my cocoon...

When you come out of your mum's basement, I suspect you'll still be the same pallid nerd.

originally posted by: chr0naut
a reply to: Violater1


And the process of testing and approval of a vaccine means that we have a good idea of how the human immune system responds to the vaccine, before we even approve it for the general populace.

I don’t know the status of approval in your country, but here in the US, NONE of these are approved for the general populace. The FDA has exempted them from having to be approved. They have not been approved.

a reply to: Violater1

I have found none.

That's because cellular division (mitosis) duplicates chromosomes (and thereby, DNA). It does not replicate mRNA. mRNA is not part of mitosis. That's why you won't find it mentioned.

originally posted by: glen200376
Modified RNA has a direct effect on DNA-don't take my word on it-

phys.org...

This is a very specific mRNA which has epigenetic effects that cause DNA to become unviable, with the result that the cells containing the unviable DNA, die.

originally posted by: marg6043
The worst of this new technology is that until today nobody knows what will happen to the body in the long term, but I am sure we will all find out now one way or the other.

Until then I will seat on the side lines and eat my popcorn.

One year after covid, I am still alive and well, soo my odds are better without the surprise long term of the china injections,

If you are from the USA or Western Europe, it is unlikely that you would have had the Chinese vaccine. The Sinovac vaccine is made from an inactivated whole virus and is not as effective as the mRNA ones.

a reply to: Violater1

Yes any molecular biology course. It’s the central dogma, you would need significant signaling to bypass the central dogma of gene expression. You can do it, we use it at work for cancers and cystic fibrosis plus other genetic issues and can get it to express in daughter cells. We’re exploring it for mitochondrial and other protein disease to cure it by using vectors in the embryo to permanently change gene expression. Say you have an abnormal gene, you put a plasmid in the nucleus that fixes that issue, the cell will use that instead and could even incorporate it into the mitochondria or nucleus and cure the genetic anomaly.

The vector we use would need to change, use a lentivirus instead, maybe an adenovirus associated vector. There just isn’t enough in the mRNA vaccine, as it’s presented since this is a conspiracy site, for this to happen. Viruses hijack nuclear transport, they arrest cell division and increase transcription and translation while stopping most cell production and move to produce virions. The cell will sometimes have to activate IRES protein production just to get the MHC complexes to activate it after it’s taken over.

Cells will also halt division once they are infected to prevent this from happening. They produce cyclins that control the cell cycle like NFKB and other regulatory mechanisms. These halt the cell cycle once abnormal proteins are identified even from the vaccines. APCs are a little different they want to take what they found to the lymph nodes and then they are removed. Bacteria love using this against the body to cause sepsis. Anthrax and ecoli, even s. Typhi.

I have not seen studies really explore this, my guess is no one would fund the thing. They have found autoimmune issues in animals with other viral targets besides the spike which could express with similar aberrant signaling, nothing with these though unless they’re hiding them. If they have them I would love to see them because it would be both terrible and extremely fascinating.

a reply to: TheAMEDDDoc
A complication with this Chinese Frankenstein, is that we don't know if these mRNA vaccines or the virus itself, has importin molecules. Importin binds to the nuclear localization signal and brings the protein to be transported to the nuclear pore. The importin, with mRNA moves through the nuclear pore into the nucleus.
Now that it is in the nucleus, a protein called Ran, which has a GTP molecule bound to it, binds to the importin with its cargo. This allows the importin to release the mRNA into the nucleus.