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Background
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
Results
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Conclusion
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
Chloroquine has been widely used to treat human diseases, such as malaria, amoebiosis, HIV, and autoimmune diseases, without significant detrimental side effects [15]. Together with data presented here, showing virus inhibition in cell culture by chloroquine doses compatible with patient treatment, these features suggest that further evaluation of chloroquine in animal models of SARS-CoV infection would be warranted as we progress toward finding effective antivirals for prevention or treatment of the disease.
Remember Fauci knows it has been working as a treatment but because of his position cannot promote it,
originally posted by: carewemust
Strange that President Trump won't spill the beans on Big Pharma moving heaven and earth to turn most Medical People and Mainstream Media against Hydroxychloroquine, because its cheap.
Maybe big Pharma has got Trump by the bawls, like Trump has the nation's governors by the bawls?
originally posted by: Observationalist
If Fauci was In charge we chop up the boat and use the wood for coffins and fire so we can keep warm on the island while we wait for the miracle rescue.
originally posted by: BlueJacket
a reply to: Observationalist
Fauci works for Bill Gates Foundation, hes on the board, this is about vaccines, id2020 and globalist control
Rushing a medication into hospitals without proper studies and permission from the FDA to move to a stage 2 or stage 3 clinical trial, that’s not on Fauci.
Pinning all of this on Fauci is from not looking at the big picture. Just my opinion.
Americans trust Dr. Anthony Fauci, the nation's top infectious-disease expert, and New York Gov. Andrew Cuomo the most when it comes to official guidance on the COVID-19 outbreak, a new Insider poll showed.
We asked respondents: "When it comes to the official advice regarding coronavirus, please rate how much you trust the following messengers on a scale on 1 to 5." Fauci and Cuomo received the highest marks, and President Donald Trump and Treasury Secretary Steve Mnuchin got the lowest average scores.
originally posted by: Observationalist
a reply to: rickymouse
Thanks for the nice reply
Remember Fauci knows it has been working as a treatment but because of his position cannot promote it,
But why is it that we wait til April 9th at the peak of the pandemic do we see any clinical testing for Chloroquine.
What if more research like this was done at the onset. Washington University launches clinical trial on controversial drug chloroquine to treat coronavirus
Wouldn’t it have been worth it to invest in trials like this earlier. Instead of Investing that that money in a vaccine that is just hypothetical.