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Originally posted by LazarusTheLong
in the past 5 years the world has cleared over 10% of its land mass for agriculture (once changed, takes forever to change back). for those that don't count, that means in 50 years... we all live in a parking lot (on top of a land fill)
* “The occurrence of fibromuscular dysplasia in the arteries of domestic turkeys.” Julian LM. Am J Pathol. 1980 Nov;101(2):415-24. PMID: 7435545
* “The ultrastructure of spontaneous coronary arterial lesions in steelhead trout (Salmo gairdneri).” House EW, Benditt EP. Am J Pathol. 1981 Sep;104(3):250-7. PMID: 7294154
* “Fibromuscular dysplasia in intramuscular arteries of Japanese quail (Coturnix coturnix japonica).” Braga IS 3rd, Tanaka S, Itakura C, Mizutani M. J Comp Pathol. 1996 Feb;114(2):123-30. PMID: 8920213
* “All forms of fibromuscular dysplasia are progressive and have variable rates of progression.”
Radiology, Vol 139, 45-51, Copyright © 1981 by Radiological Society of North America. Progression of renal artery fibromuscular dysplasia in 42 patients as seen on angiography. V Goncharenko, AJ Gerlock Jr, MI Shaff and JW Hollifield.
radiology.rsnajnls.org...
* “Fibromuscular dysplasia is a chronic progressive disease and some cases progress rapidly in a few months.”
Angiology. 1999 Feb;50(2):153-6. Fibromuscular dysplasia involving coronary arteries--a case report. Ogawa T, Nomura A, Komatsu H, Fujii S, Urasawa K, Okamoto H, Kitabatake A. Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan. PMID: 10063947
* “Age and fibroplasia as preconditions for atheronecrosis in human coronary arteries.” Arch Pathol Lab Med 1987 Oct;111 (10):957-63 Tracy RE, Kissling GE. PMID: 3632271
* “Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults.” Arteriosclerosis. 1989 Jan-Feb;9(1 Suppl):I19-32 Stary HC. Louisiana State University, School of Medicine, New Orleans 70112. PMID: 2912430
For example:
“Fibromuscular dysplasia in a child: a generalized arterial disease.” Acta Paediatr Scand 1980 Jul;69(4):563-6. Pesonen E, Koskimies O, Rapola J, Jaakelainen J. PMID: 7446106
“Fibromuscular dysplasia may be a systemic disease…, and may affect the central nervous system.”
Renovascular hypertension and demyelimating disease in a young woman. Alaska Med 1989 Jul-Dec;31(4):137-43. Neubauer RL. PMID: 2596648
“This report suggests that FMD should be considered to be a systemic angiopathy…”
“Clinical significance of cerebral aneurysm in renovascular hypertension due to fibromuscular dysplasia: two cases in siblings.” Angiology 1989 Jun;40 (6):581-8. Ouchi Y, Tagawa H, Yamakado M, Takanashi R, Tanaka S. Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan. PMID: 2719343
“Focal fibromuscular dysplasia of small coronary arteries is not so rare as it is unrecognized.”
Morphologic characteristics and functional significance of focal fibromuscular dysplasia of small coronary arteries. Am J Cardiol. 1990 Apr 3;65(14):12G-22G. James TN. World Health Organization Cardiovascular Center, Galveston, Texas. PMID: 2181850
* The causes of death in patients with carotid FMD were heart attack (44.4%), cancer (33.3%) and stroke (22.2%) – now the three leading causes of death in the USA, in that order.
“Fibromuscular dysplasia of the internal carotid artery: long-term surgical results.” J Cardiovasc Surg (Torino). 1993 Dec;34(6):465-72. Moreau P, Albat B, Thevenet A. Service de Chirurgie Thoracique et Cardio-Vasculaire, Centre Hospitalier Universitaire, Montpellier, France. PMID: 8300709
“Trends for mortality from heart disease, stroke, lung cancer, and, less distinctly, cancer other than lung cancer, tend to be similar in different countries, ... suggesting the existence of common causes amenable to the same preventive measures.”
Circulation. 1994 Jul;90(1):574-82. Heart disease, cancer, and stroke mortality trends and their interrelations. An international perspective. Thom TJ, Epstein FH. Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. PMID: 8026045
circ.ahajournals.org...;90/1/574
www.emedicine.com...
“FMD frequency in the USA: incidence of new cases in adults diagnosed by angiography – 0.6%; diagnosed in autopsy – 1.1%.”
NOTE: Incidence means new cases found yearly, presented as a % of the total population.
Also see Puri, PMID: 10334397.
FMD INCIDENCE in the USA
YEAR - DEATHS - TOTAL POP - EST ADULT POP (75%) - 1.1% ADULT POP:
FMD incid in autopsy
1999 - 2,391,399 - 279,295,000 - 209,471,250 - 2,304,184
1998 - 2,337,256 - 276,115,000 - 207,086,250 - 2,277,949
1997 - 2,314,245 - 272,912,000 - 204,684,000 - 2,251,524
1996 - 2,314,690 - 269,667,000 - 202,250,250 - 2,224,750
1995 - 2,312,132 - 266,557,000 - 199,917,750 - 2,199,095
Source: Population: Census; Reported Deaths; World Health Organization.
Originally posted by LazarusTheLong
The prion plague in perhaps a problem... but it only serves the need for culling the herd, so it is more of a solution than a problem...
...I would think they are using this as a method of herd culling... (your point) but is that bad?
clarify if you would sofi:
how is this prion disease different from heart disease?
the effects seem to be the same, and the death stats seem to mimic each other...
could it be that heart disease is the prion disease, and we have known about it by another name all this time... and just now realize it is what heart disease is...?
For example:
“Fibromuscular dysplasia in a child: a generalized arterial disease.” Acta Paediatr Scand 1980 Jul;69(4):563-6. Pesonen E, Koskimies O, Rapola J, Jaakelainen J. PMID: 7446106
“Fibromuscular dysplasia may be a systemic disease…, and may affect the central nervous system.”
Renovascular hypertension and demyelimating disease in a young woman. Alaska Med 1989 Jul-Dec;31(4):137-43. Neubauer RL. PMID: 2596648
“This report suggests that FMD should be considered to be a systemic angiopathy…”
“Clinical significance of cerebral aneurysm in renovascular hypertension due to fibromuscular dysplasia: two cases in siblings.” Angiology 1989 Jun;40 (6):581-8. Ouchi Y, Tagawa H, Yamakado M, Takanashi R, Tanaka S. Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan. PMID: 2719343
“Focal fibromuscular dysplasia of small coronary arteries is not so rare as it is unrecognized.”
Morphologic characteristics and functional significance of focal fibromuscular dysplasia of small coronary arteries. Am J Cardiol. 1990 Apr 3;65(14):12G-22G. James TN. World Health Organization Cardiovascular Center, Galveston, Texas. PMID: 2181850
* The causes of death in patients with carotid FMD were heart attack (44.4%), cancer (33.3%) and stroke (22.2%) – now the three leading causes of death in the USA, in that order.
“Fibromuscular dysplasia of the internal carotid artery: long-term surgical results.” J Cardiovasc Surg (Torino). 1993 Dec;34(6):465-72. Moreau P, Albat B, Thevenet A. Service de Chirurgie Thoracique et Cardio-Vasculaire, Centre Hospitalier Universitaire, Montpellier, France. PMID: 8300709
“Trends for mortality from heart disease, stroke, lung cancer, and, less distinctly, cancer other than lung cancer, tend to be similar in different countries, ... suggesting the existence of common causes amenable to the same preventive measures.”
Circulation. 1994 Jul;90(1):574-82. Heart disease, cancer, and stroke mortality trends and their interrelations. An international perspective. Thom TJ, Epstein FH. Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. PMID: 8026045
circ.ahajournals.org...;90/1/574
www.emedicine.com...
“FMD frequency in the USA: incidence of new cases in adults diagnosed by angiography – 0.6%; diagnosed in autopsy – 1.1%.”
NOTE: Incidence means new cases found yearly, presented as a % of the total population.
Also see Puri, PMID: 10334397.
FMD INCIDENCE in the USA
YEAR - DEATHS - TOTAL POP - EST ADULT POP (75%) - 1.1% ADULT POP:
FMD incid in autopsy
1999 - 2,391,399 - 279,295,000 - 209,471,250 - 2,304,184
1998 - 2,337,256 - 276,115,000 - 207,086,250 - 2,277,949
1997 - 2,314,245 - 272,912,000 - 204,684,000 - 2,251,524
1996 - 2,314,690 - 269,667,000 - 202,250,250 - 2,224,750
1995 - 2,312,132 - 266,557,000 - 199,917,750 - 2,199,095
Source: Population: Census; Reported Deaths; World Health Organization.
same is true in africa... the civilized world has left the large part of the continent to its own destuction for decades... this is because they had hoped that it would solve its own problems with war famine and disease...
in another thread, i pointed out that science does have a cure, but can't use it until the population of the world is stable...(and nothing will be done before that)
in fact... if a prion disease was rampant in the population... it would be a good thing for mother earth... and our children...(the ones arising from immune couples)...
much like many of the longevity medicines will coincidentally be released when the population can handle the stress...
facts are facts...
this world ain't big enough for all of us, and our health...
Originally posted by zman
Sorrry , to say that we are a drain on the sociaty , that is people like me with MS is wrong ..
I have served my country in the AF , I have worked on the space shuttle comunication system in its infancy , I was a broadcast engineer for ABC , my last employment was training the National Guard in simulated desert war fare up and down the east coast in the bradley fighting vehicle and abrams tank. To say I was a drain on the sociaty is totaly wrong. I worked , I did not get any conpensation from government programs .. I am doing my part by paying taxes so those less fortunit can live off the government. I have in my enigineering experiance been developing new enegry sources and other projects , my main hero is tesla , and damm if I will let people tell me I am not valuable to the whole. Many blessings ..
Originally posted by radagast
as far as deciding which people to get rid of first, maybe we can have a "logans run" scenario, when you turn 30, you're outta here.....
Originally posted by Ghaleon4
Soficrow:
You're scaring the SH-T out of everyone here man...seriously...you've done all this research, can you PLEASE give us some good news!?
SHEESH...
What can we do already?!
* “Blood test for prions?” 23 November 2000 www.nature.com...
* “Antibodies could combat prion-based diseases” August 2, 2001 www.biomedcentral.com...
* “Antibodies cripple prions.” 6 March 2003 www.nature.com...
* “Scientific Advance Establishes 'Proof Of Principle' That Prion Diseases Might Be Prevented” 6 March 2003, Nature. www.sciencedaily.com...
* “Researchers Discover Possible Diagnosis, Treatment, Vaccine For Mad Cow, Prion Diseases” 2003-06-02
www.sciencedaily.com...
...although a trend exists for the risk of infection with prion disease to increase with repeated doses, it does so to a lesser degree than is expected if challenges combine independently or in a cumulative manner.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10960-5. Epub 2003 Sep 05. Repeated challenge with prion disease: the risk of infection and impact on incubation period. Gravenor MB, Stallard N, Curnow R, McLean AR. Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom. [email protected] PMID: 12960400
...image a test tube full of food for bacteria to last 60 minutes, and imagine that we introduce a single bacterium that divides each minute. Because the population doubles every minute, you get exponential population growth. At 60 minutes, the test tube is full of bacteria and all the food is gone. Now here’s the interesting part: the test tube is 50% full at *59 MINUTES*, 25% full at *58 MINUTES*… 3% full at 55 minutes …
So Suzuki continues and proposes: Perhaps one of the bacterium figure out they’re going to run out of food at 55 minutes (3% full). So if the bacteria use all their resources to create another 3 test tubes of food, you’d think they would be saved wouldn’t they? Well, at 60 minutes the first test tube would be full of bacteria. At 61 minutes, the second test tube would be full of bacteria. At 62 minutes, all four test tubes would be full of bacteria. So they only bought themselves 2 more minutes of time even though they quadrupled their food.
The point of all this? Most scientists believe that we are well into the 59th minute.
Originally posted by Kidfinger
Sofi. Have you done any research on protien enzymes? Scientist have used a special enzime that attaches to DNA and severs it at a certain spot rendering it effectivly usless. Apparently it is used alot in recumbanant DNA research, and has the potential to be the virus killer of all virus killers. There are different forms of this enzyme. They all cut the DNA, they each just do it in a different place.
Some quicks refs:
“…prions are notoriously difficult to break down… A new disinfectant, based on enzymes collected from a volcanic pool, is showing promise in destroying the mutated prion proteins…
“We don't know why prions are so highly stable, but they are extremely hard to destroy. Indeed, one standard method of decontamination – soaking in fomaldehyde – actually stabilises the prions.”
* “Volcanic pool enzyme kills prions” 29 July 03
www.newscientist.com...
* “Scientists Discover That Enzyme Degrades Mad Cow Disease Prion,” North Carolina State University press release, January 5, 2004. J. Shih.
www.ncsu.edu...
Novel methods for disinfection of prion-contaminated medical devices. Lancet. 2004 Aug 7;364(9433):521-6. Fichet G, Comoy E, Duval C, Antloga K, Dehen C, Charbonnier A, McDonnell G, Brown P, Lasmezas CI, Deslys JP. CEA/DSV/DRM/GIDTIP, Route du Panorama, 92265 Fontenay-aux-Roses, France.
ncbi
Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5253-60. Baxa U, Speransky V, Steven AC, Wickner RB. Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. PMID: 11959975
www.pnas.org...
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J Virol. 2003 Oct;77(19):10288-94. Kocisko DA, Baron GS, Rubenstein R, Chen J, Kuizon S, Caughey B. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA. PMID: 12970413
jvi.asm.org...
"Mitochondrial oxidative stress has been implicated in heart disease including myocardial preconditioning, ischemia/reperfusion, and other pathologies. In addition, oxidative stress in the mitochondria is associated with the pathogenesis of Alzheimer's disease, Parkinson's disease, prion diseases, and amyotrophic lateral sclerosis (ALS) as well as aging itself."
Applied proteomics: mitochondrial proteins and effect on function. Circ Res. 2002 Mar 8;90(4):380-9. Lopez MF, Melov S. Proteome Systems, Woburn, MA 01801, USA. [email protected] PMID: 11884366
circres.ahajournals.org...
Originally posted by soficrow
...enzymes that cut DNA don't touch prions because prions have no DNA. But new enzymes have been found that do kill prions...