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The negative effects of mCPP, often typical of a serotonin syndrome, include anxiety, dizziness, confusion, shivering, sensitivity to light and noise, fear of losing control, migraine and panic attacks (Gijsman et al., 1998; Tancer and Johanson, 2001, 2003; Feuchtl et al., 2004). A serotonin syndrome was found to occur in some psychiatric patients following oral dosing with mCPP (0.5mg/kg), but did not occur in normal volunteers at the same plasma concentrations (Klaassen et al., 1998). Unlike MDMA, mCPP lacks neurotoxic potential (Gobbi et al., 2002) and mCPP releases 5HT without causing long-term depletion (Ulrichsen et al., 1992; Baumann et al., 2001). This difference between MDMA and mCPP may be related to the ability of mCPP to release cytoplasmatic 5HT, whereas MDMA induces the release of both cytoplasmatic and vesicular 5HT (Gobbi et al., 2002). The main enzyme involved in hydroxylation of mCPP is CYP2D6, the activity of which is subject to considerable genetic variability (Bertilsson et al., 2002). Since this enzyme is involved with the metabolism of many other drugs, ‘slow-metabolisers’ are most at risk of drug interactions (Pritzker et al., 2002). Variability in CYP2D6 phenotype may partly explain the wide variation in the pharmacokinetics of mCPP as noted above. No fatal poisonings from mCPP have been reported. Although Goeringer et al. (2000) and Martinez et al. (2005) gave details of a number of fatalities due to Trazodone, it is unclear what part the metabolite mCPP played in these deaths. Little is known about the mutagenic and carcinogenic potential of mCPP or its effects on other organ systems. Read more: www.drugs-forum.com...
Originally posted by _BLiND_
Oh man...next time don't buy from the dealer that told you that.
Originally posted by Xieon
Anyway, most of the Nazi Zombies from the Call of Duty series is in fact based in fact. If anyone wants a specific example I'll be happy to help.edit on 29-3-2012 by Xieon because: (no reason given)edit on 29-3-2012 by Xieon because: (no reason given)
Originally posted by CodyOutlaw
Originally posted by Xieon
Anyway, most of the Nazi Zombies from the Call of Duty series is in fact based in fact. If anyone wants a specific example I'll be happy to help.edit on 29-3-2012 by Xieon because: (no reason given)edit on 29-3-2012 by Xieon because: (no reason given)
I would like to hear a specific example.
If and when you have time.