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Researchers at the Center for Brain Health at the University of Texas in Dallas sought to clear up some of the confusion with a study that looked at a relatively large group of marijuana users and evaluated their brains for a slew of different indicators.
What they found was complex, but the pattern was clear: The brains of marijuana users were different than those of non-marijuana users. The area of the brain responsible for establishing the reward system that helps us survive and also keeps us motivated was smaller in users than in non-marijuana users. But there was also evidence that the brain compensated for this loss of volume by increasing connectivity and the structural integrity of the brain tissue.
The study, published Monday in the Proceedings of the National Academy of Sciences, used MRI scans to look at the brains of 62 non-marijuana users and 48 regular marijuana users, 27 of whom used marijuana but not other drugs. The marijuana users reported ingesting the drug about three times a day -- very heavy use -- and had used it for an average of about 10 years.
Looking first at atypically heavy marijuana use is necessary to identify structural effects, if there are any, Filbey said. Subsequent research would look at varying levels of use to find out if differences compared to non-users are still observed. For example, in Colorado, only about 22 percent of marijuana users reported using the drug about once a day at most.
Relative to other studies, this one had a fairly large sample size; it also excluded participants who had symptoms of psychosis, brain injury or neurological disorders in order to reduce the likelihood that the tests would pick up on other confounding factors. And it looked at three brain characteristics: the volume of the orbitofrontal cortex, how connected that part of the brain was to other areas, and the structural integrity of the white matter.
"We found that while the orbitofrontal cortex was smaller, there was greater functional and structural connectivity," said Filbey. "The white matter seemed to have greater integrity than the [non-marijuana using group]. And the connection between the orbitofrontal cortex and other areas were stronger."
That's potentially positive news suggesting that whatever impact marijuana use might have on the size or volume of that part of the brain, it may be offset by better connectivity and structural soundness. "It suggests that there is definitely a more complicated pattern that the brain seems to be able to compensate for any kind of loss in order to keep that network maintained," Filbey said.
There is no proven connection between the structural characteristics of this area in the brain and certain behaviors in humans. And it is possible that the small orbitofrontal cortex observed in marijuana users predated their marijuana use. A 2012 study found that smaller orbital frontal cortex volume at 12 years of age appeared to predict the initiation of marijuana use later in life.
originally posted by: Krazysh0t
a reply to: Calalini
Washington Post has a history of posting anti-marijuana propaganda, jumping on studies like this whenever they are published and spinning them as above.
I personally, wish the article would have explored the increased white matter connectivity that the study showed more, but instead WP decided to downplay it instead.
Looking first at atypically heavy marijuana use is necessary to identify structural effects, if there are any, Filbey said.
originally posted by: Calalini
a reply to: Krazysh0t
It wouldn't matter where the article was posted or who ran the study. It would automatically be relegated to propaganda and wouldn't be taken seriously whatsoever. You can take that to the bank. Already the spin is on in this very thread. "Well, this can't be true. What it actually means is that marijuana is (wonderful in some way)."
Again, if it's so wonderful, give it to your children.
originally posted by: Krazysh0t
a reply to: Calalini
Washington Post has a history of posting anti-marijuana propaganda, jumping on studies like this whenever they are published and spinning them as above.
I personally, wish the article would have explored the increased white matter connectivity that the study showed more, but instead WP decided to downplay it instead.
"Once again, researchers have failed to find any conclusive evidence that marijuana use causes mental health problems. The researchers note their findings are nonconclusive, that they might be skewed by other factors, and that effects, if any, could be temporary, Tvert said. "The study doesn't justify keeping marijuana illegal, nor does it say anything about making it legal. There remains no doubt that marijuana is far less harmful than alcohol to the brain and to the rest of the body. The possibility that marijuana might have some harm for some people -- but might not -- is not a good reason to keep arresting and punishing hundreds of thousands of adults simply for using it."
originally posted by: Krazysh0t
a reply to: Calalini
It's just the backlash from all the "Pot is the devil!" propaganda that we had in the 80's. When you push too hard in one direction, you will get equal backlash in the opposite direction. It would be nice if policy makers would wise up to that.