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METHODS
We conducted a retrospective cohort study of all children born in Denmark from January 1991 through December 1998. The cohort was selected on the basis of data from the Danish Civil Registration System, which assigns a unique identification number to every live-born infant and new resident in Denmark. MMR-vaccination status was obtained from the Danish National Board of Health. Information on the children's autism status was obtained from the Danish Psychiatric Central Register, which contains information on all diagnoses received by patients in psychiatric hospitals and outpatient clinics in Denmark. We obtained information on potential confounders from the Danish Medical Birth Registry, the National Hospital Registry, and Statistics Denmark.
Full Text of Methods...
RESULTS
Of the 537,303 children in the cohort (representing 2,129,864 person-years), 440,655 (82.0 percent) had received the MMR vaccine. We identified 316 children with a diagnosis of autistic disorder and 422 with a diagnosis of other autistic-spectrum disorders. After adjustment for potential confounders, the relative risk of autistic disorder in the group of vaccinated children, as compared with the unvaccinated group, was 0.92 (95 percent confidence interval, 0.68 to 1.24), and the relative risk of another autistic-spectrum disorder was 0.83 (95 percent confidence interval, 0.65 to 1.07). There was no association between the age at the time of vaccination, the time since vaccination, or the date of vaccination and the development of autistic disorder.
Full Text of Results...
CONCLUSIONS
This study provides strong evidence against the hypothesis that MMR vaccination causes autism.
originally posted by: ScepticScot
a reply to: rickymouse
Again where is the evidence to support this? Why 5 safe vaccinations? What makes you think mmr combines with other vaccinations to cause autism? it is not a case of people not accepting research it is that there is an absence of research supporting the claims you are making.
originally posted by: GetHyped
a reply to: rickymouse
There have been lots of studies researching the safety of multiple vaccines:
www2.aap.org...
originally posted by: GetHyped
a reply to: GreenMtnBoys
Why on earth would you need to blind a study on vaccines/autism link? Autism isn't exactly a placebo effect. Anyway, denying ignorance and all that, here's a study where they compared the autism and vaccine rates of an entire country:
www.nejm.org...
METHODS
We conducted a retrospective cohort study of all children born in Denmark from January 1991 through December 1998. The cohort was selected on the basis of data from the Danish Civil Registration System, which assigns a unique identification number to every live-born infant and new resident in Denmark. MMR-vaccination status was obtained from the Danish National Board of Health. Information on the children's autism status was obtained from the Danish Psychiatric Central Register, which contains information on all diagnoses received by patients in psychiatric hospitals and outpatient clinics in Denmark. We obtained information on potential confounders from the Danish Medical Birth Registry, the National Hospital Registry, and Statistics Denmark.
Full Text of Methods...
RESULTS
Of the 537,303 children in the cohort (representing 2,129,864 person-years), 440,655 (82.0 percent) had received the MMR vaccine. We identified 316 children with a diagnosis of autistic disorder and 422 with a diagnosis of other autistic-spectrum disorders. After adjustment for potential confounders, the relative risk of autistic disorder in the group of vaccinated children, as compared with the unvaccinated group, was 0.92 (95 percent confidence interval, 0.68 to 1.24), and the relative risk of another autistic-spectrum disorder was 0.83 (95 percent confidence interval, 0.65 to 1.07). There was no association between the age at the time of vaccination, the time since vaccination, or the date of vaccination and the development of autistic disorder.
Full Text of Results...
CONCLUSIONS
This study provides strong evidence against the hypothesis that MMR vaccination causes autism.
www.nejm.org...
Kreesten Meldgaard Madsen, M.D., Anders Hviid, M.Sc., Mogens Vestergaard, M.D., Diana Schendel, Ph.D., Jan Wohlfahrt, M.Sc., Poul Thorsen, M.D., Jørn Olsen, M.D., and Mads Melbye, M.D.
www.justice.gov...
Thorsen Allegedly Absconded With Over $1 Million
ATLANTA, GA - POUL THORSEN, 49, of Denmark, has been indicted by a federal grand jury on charges of wire fraud and money laundering based on a scheme to steal grant money the CDC had awarded to governmental agencies in Denmark for autism research.
United States Attorney Sally Quillian Yates said of the case, “Grant money for disease research is a precious commodity. When grant funds are stolen, we lose not only the money, but also the opportunity to better understand and cure debilitating diseases. This defendant is alleged to have orchestrated a scheme to steal over $1 million in CDC grant money earmarked for autism research. We will now seek the defendant’s extradition for him to face federal charges in the United States.”
“Stealing research grant money to line his pockets, as Poul Thorsen stands accused of here today, cheats U.S. taxpayers and will simply not be tolerated,” said Derrick L. Jackson, Special Agent in Charge of the Atlanta Region for the Office of Inspector General of the Department of Health & Human Services. “HHS/OIG will continue to work closely with our law enforcement partners to bring these criminals to justice.”
Reginael D. McDaniel, Special Agent in Charge of the Atlanta Region for Internal Revenue Service Criminal Investigation said, “Today’s global economy demands a high-level coordinated approach by multiple agencies and authorities in the investigation of financial crimes. While schemes often become more sophisticated over time, fortunately, so do our investigative techniques. IRS Criminal Investigation is proud to have shared its hallmark expertise in following the money trail in the scheme alleged in this indictment.”
According to United States Attorney Yates, the charges and other information presented in court: In the 1990s, THORSEN worked as a visiting scientist at the U.S. Centers for Disease Control and Prevention (CDC), Division of Birth Defects and Developmental Disabilities, when the CDC was soliciting grant applications for research related to infant disabilities. THORSEN successfully promoted the idea of awarding the grant to Denmark and provided input and guidance for the research to be conducted. From 2000 to 2009, the CDC awarded over $11 million to two governmental agencies in Denmark to study the relationship between autism and exposure to vaccines, between cerebral palsy and infection during pregnancy, and between childhood development and fetal alcohol exposure. In 2002, THORSEN moved to Denmark and became the principal investigator for the grant, responsible for administering the research money awarded by the CDC.
originally posted by: GetHyped
a reply to: riley
Ad hominem much? Critique the science, not the person. Ironic considering your savior Mr Wakefield falsified his data so he could make a quick buck on his own replacement vaccine.
While you're at it, make some headway at debunking all of these papers:
www2.aap.org...
Oh I'm not going to bother even looking at whatever papers you posted you're just changing the topic.
originally posted by: GetHyped
a reply to: riley
Ad hominem again. There are many authors on that paper, the person in question wasn't even the lead author. So again, do you have any criticism of the methodology, data and conclusions of the study?
Actually Poul Thorsen was the lead author/director. He was in charge of writing the final conclusions. Heis now on the run for FRAUD and grand theft over stealing money the same study he was commissioned to do. If a lead scientist is of questionable integrity it is not unreasonable to question the integrity of his work.
Also, have you read all of the other papers I linked to? Probably not. I'll await your debunking of those papers as well.
Oh I'm not going to bother even looking at whatever papers you posted you're just changing the topic.
Is that French for "I can't debunk those studies"? Staying on topic, let's start with that first paper. Critique away, my friend!
www.ncbi.nlm.nih.gov...
Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002.
Gallagher CM1, Goodman MS.
Author information
1PhD Program in Population Health and Clinical Outcomes Research, Stony Brook University Medical Center, State University of New York at Stony Brook, Stony Brook, New York, USA. [email protected]
Abstract
Universal hepatitis B vaccination was recommended for U.S. newborns in 1991; however, safety findings are mixed. The association between hepatitis B vaccination of male neonates and parental report of autism diagnosis was determined. This cross-sectional study used weighted probability samples obtained from National Health Interview Survey 1997-2002 data sets. Vaccination status was determined from the vaccination record. Logistic regression was used to estimate the odds for autism diagnosis associated with neonatal hepatitis B vaccination among boys age 3-17 years, born before 1999, adjusted for race, maternal education, and two-parent household. Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Non-Hispanic white boys were 64% less likely to have autism diagnosis relative to nonwhite boysFindings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period. Nonwhite boys bore a greater risk.
www.ncbi.nlm.nih.gov...
A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population.
Delong G.
Author information
Department of Economics and Finance, Baruch College/City University of New York, New York, New York, USA. [email protected]
Abstract
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery. Although individuals probably have a genetic predisposition to develop autism, researchers suspect that one or more environmental triggers are also needed. One of those triggers might be the battery of vaccinations that young children receive. Using regression analysis and controlling for family income and ethnicity, the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each U.S. state from 2001 and 2007 was determined. A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT or SLI. A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI. Neither parental behavior nor access to care affected the results, since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a U.S. state. The results suggest that although mercury has been removed from many vaccines, other culprits may link vaccines to autism. Further study into the relationship between vaccines and autism is warranted.
www.ncbi.nlm.nih.gov...
Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism.
Singh VK1, Lin SX, Newell E, Nelson C.
Author information
1Department of Biology and Biotechnology Center, Utah State University, Logan, Utah 84322, USA. [email protected]
Abstract
(Snip) This antibody specifically detected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal antibodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.
Copyright 2002 National Science Council, ROC and S. Karger AG, Basel
originally posted by: rileyAs already said this isn't about debunking all other autism/vaccine studies.
Singh’s work has not been replicated. [edited to add]As Paul Offit wrote on page 45 of Autism's False Prophets,
...a closer look at Singh's science revealed two critical flaws: children with autism didn't have nerve damage and, according to measles experts, the test that Singh had used to detect measles antibodies didn't detect them.
Multiple studies in multiple countries with tens of thousands of subjects have repeatedly failed to find an association between measles vaccine and autism.
Multiple studies in multiple countries with tens of thousands of subjects have repeatedly failed to find an association between measles vaccine and autism.
www.immunizationinfo.org...
www.immunizationinfo.org...
To big to fall? That makes no sense, drug companies would settle out of court, a fraction of their profits would go to families and law firms and they would move on. This would not crush them, not by a long shot.