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In a new study published in the peer reviewed Public Library of Science (PLOS), researchers emphasize that there is sufficient evidence that meal-derived DNA fragments carry complete genes that can enter into the human circulation system through an unknown mechanism
The study was based on the analysis of over 1000 human samples from four independent studies. PLOS is an open access, well respected peer-reviewed scientific journal that covers primary research from disciplines within science and medicine. It’s great to see this study published in it, confirming what many have been suspecting for years.
Food.
DNA from consumed food is usually not considered as a possible source of cfDNA since during food digestion all macromolecules are thought to be degraded to elementary constituents such as amino acids and nucleotides, which are then transferred to the circulatory system through several complex active processes [3]. Though, there are animal studies, mainly focusing on the GMO issue [4], supporting the idea that small fragments of nucleic acids may pass to the bloodstream and even get into various tissues. For example foreign DNA fragments were detected by PCR based techniques in the digestive tract and leukocytes of rainbow trouts fed by genetically modified soybean [37], and other studies report similar results in goats [38], pigs [39], [40] and mice [5].
Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples while non-plasma (cord blood) control sample was found to be free of plant DNA.
Conclusion
The analysis of all the publicly available circulating cell-free DNA sequencing data of over 1000 human subjects confirms our hypothesis that the presence of foreign DNA in human plasma is not unusual. It shows large variation from subject to subject following strikingly well a log-normal distribution with the highest concentration in patients with inflammation (Kawasaki disease, IBD). These findings could lead to a revision of our view of degradation and absorption mechanisms of nucleic acids in the human body.
Complete Genes May Pass from Food to Human Blood
The analysis of all the publicly available circulating cell-free DNA sequencing data of over 1000 human subjects confirms our hypothesis that the presence of foreign DNA in human plasma is not unusual.
Food is our fuel, and its nutrients give our bodies' cells the energy and substances they need to operate. But before food can do that, it must be digested into small pieces the body can absorb and use.
The notion that eating carrots improves eyesight sounds like a story your mother made up to get you to eat your vegetables. But is there any truth to it? According to Duke ophthalmologist Jill Koury, MD, there is a connection between eating carrots and maintaining good eyesight.
It's pretty scary actually.
I think I'll stop eating carrots. All that carrot DNA might make me turn into one.
I don't know about "certainly" but I suppose it's possible.
It is certainly possible that bastardised DNA sequences that our bodies are not use could react badly with our bodies.
I don't know about "certainly" but I suppose it's possible.
But what do you think it is that is so different about "bastardized" DNA fragments though? Why would they be more dangerous than say, DNA fragments from a durian fruit? I've never eaten a durian. My body isn't "used to" durian DNA fragments.
But that does not explain why GM genes can be more dangerous than natural mutations which are part of that "order". You mentioned lateral gene transfer. Why think that it is more likely to occur with GM genes than natural genes? Why think that it if does happen, it would be more harmful?
The difference is that nature follows its own patterns and order.
If we didn't "work outside" nature we would still be as small bands of people living in caves. Afraid of the night.
If we work outside that remit then we tinkering with something we have very little understanding.
Phage
reply to post by Brotherman
It's pretty scary actually.
I think I'll stop eating carrots. All that carrot DNA might make me turn into one.