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2009: Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration.
…To date, 61% of the 433 known human cases of H5N1 infection have proved fatal. Animals infected by H5N1 viruses have demonstrated acute neurological signs ranging from mild encephalitis to motor disturbances to coma. However, no studies have examined the longer-term neurologic consequences of H5N1 infection among surviving hosts. …Our results suggest that a pandemic H5N1 pathogen, or other neurotropic influenza virus, could initiate CNS disorders of protein aggregation including Parkinson's and Alzheimer's diseases.
The WHO is investigating the death because initial reports have suggested the woman's symptoms were not entirely typical of H5N1 infections. Alberta's chief medical health office has said the woman had neurological symptoms that made doctors suspect she had encephalitis, or a brain infection.
It's not a common symptom of flu but has been reported in some H5N1 cases.
It's not known if an autopsy has been done.
Oct 10, 2012 - An H5N1 highly pathogenic avian influenza virus was isolated from conjunctiva of a whooper swan with neurological signs, which was captured during the latest H5N1 ... PMID: 23053526
Nov 5, 2013 - To evaluate the pathogenicity of a 2012 H5N1 HPAIV isolate and to ... In the infected ducks, clinical signs of disease, including neurological disorder, were observed. ... PMID: 24211664
2005. Bird Flu and Beyond: Chronic Disease to Kill 400 Million …the flu has long term impacts in survivors
Chronic disease results from pollution and industrial contamination, working in combination with very slowly progressive prion diseases. Infectious prions use the immune system to spread in the body, and spread more rapidly when the body is fighting infection - so most people who survive bird flu will suffer increasingly debilitating chronic disease.
Dianec
I thought of the symptoms eagles are having when you described CNS symptoms in people (how the raptors appeared to be paralyzed and out of it). The eagle deaths have reached 40 in Utah and they are calling the culprit West Nile virus. ...How much of this spread is from climate change?
I don't mean to take this off topic - it just came to mind. I understand the woman in Canada who died of the H5N1 was young and had no contact with birds while in China ...A man in China died of this with the same circumstances - no contact with birds. If it isn't being transmitted person to person perhaps it is like West Nile virus - a mosquito or other insect bite.
So, this would be on the order of the chicken pox virus going dormant, to perhaps unleash shingles on a person years later?
Is this a common mechanism for viruses?
...the flu planting a memory in our bodies - in its favor, or lying dormant would be a survival mechanism. While we think we have beat it - it has set up shop for a future generation of itself.
We have always looked at it from an immunity standpoint (how our bodies adapt after symptoms are gone). What of the adaptation within that we can't see?
...the flu planting a memory in our bodies - in its favor, or lying dormant would be a survival mechanism. While we think we have beat it - it has set up shop for a future generation of itself.
We have always looked at it from an immunity standpoint (how our bodies adapt after symptoms are gone). What of the adaptation within that we can't see?
Chronic disease to cost $47 trillion by 2030: WEF
…Mental health [including the dementias], which is typically left off lists of leading NCDs, will account for $16 trillion -- a third of the overall $47 trillion anticipated costs.
Report details brain complications in Canada's H5N1 case.
Brain complications in previous H5N1 cases
The authors say brain infections are uncommon in H5N1 cases, although animal studies show that the virus can invade the central nervous system (CNS). They reference a review of human H5N1 cases published in The Lancet in 2008, which cited one patient who had a coma along with evidence of the virus in CSF, suggesting CNS involvement. That review also said a few autopsies of H5N1 victims suggested that the virus replicated in nonrespiratory tissues, including the brain.
...neurologic manifestations are seen occasionally in seasonal flu cases and have been reported in a few H5N1 cases.
...influenza virus infection of the respiratory tract can cause cytokine dysregulation, the intense inflammatory response also known as cytokine storm, and this is believed to be the cause of neurologic complications in seasonal flu cases.
"Seasonal influenza viruses are not thought to be infecting the brain," Uyeki said. "But inflammation can produce a fulminant encephalitis."
In the rare H5N1 cases with neurologic complications, however, the picture seems a little different, in that there has been some evidence of actual infection in the brain, he said.
For example, a 2007 report in The Lancet reported on two H5N1 cases, one of which involved a man who had pneumonia and, while hospitalized, experienced irritability and convulsions followed by decreased consciousness. An autopsy revealed evidence of H5N1 virus infection in his brain, Uyeki said, adding, "So that suggests that H5N1 virus can directly infect brain tissue. H5N1 virus can disseminate from the lungs into the blood, and then spread throughout the body, including to the CNS."
He also noted that in a report in the New England Journal of Medicine in 2005, H5N1 virus was isolated from the CSF in a child with encephalitis who died.
…Uyeki also commented that a few other H5N1 cases with CNS complications have occurred worldwide but have not been reported publicly. "It's not unprecedented, but it's probably rare," he said.
I'm not sure about this antiviral they want to give people "just in case" since I've read it can kill other stuff in your body too.
Dianec
reply to post by DontTreadOnMe
I never thought of it from the chicken pox/shingles view but the flu planting a memory in our bodies - in its favor, or lying dormant would be a survival mechanism. While we think we have beat it - it has set up shop for a future generation of itself.
We have always looked at it from an immunity standpoint (how our bodies adapt after symptoms are gone). What of the adaptation within that we can't see?