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Originally posted by engineer
...My statement referred to "microbes" crossing previously uncrossable barriers, not "organisms." You are right, infectious prions are proteins and do not have genetic material - this is what enables them to cross kingdom barriers.
Well, you still haven't given us an example of a microbe making a cross kingdom jump. And microbes are organisms. Think about cross kingdom transmission. ??? I've never heard of such a thing before.
"During the 10 year period 1968-78, major discoveries relevant to plant sciences were being made in several microbiology laboratories around the world. Fundamental knowledge was being acquired about the molecular mechanism leading to crown gall formation, the interkingdom transfer of DNA from a bacterium to a plant cell."
Ten years dedicated to the Laboratory of Genetics, Gent
The Plant Journal. Volume 23 Issue 1 Page 3 - July 2000
www.blackwell-synergy.com...
"Agrobacterium tumefaciens is a soil bacterium that causes the neoplastic disease Crown Gall on hundreds of plant species. ...The molecular mechanism by which Agrobacterium transforms cells involves the transfer of a segment of DNA, the T-(transferred) DNA, from a resident plasmid to the host genome. This horizontal gene transfer between species of different phylogenetic kingdoms is unique in nature, but is an extension of intra-kingdom DNA exchange (conjugation) commonly seen among bacteria. Recently, scientists have learned that this �DNA exchange� really represents �protein exchange� "
�The Molecular Mechanism of Plant Genetic Transformation by Agrobacterium tumefaciens, Nature�s Genetic Engineer�
www.purdue.edu...
"Complete genomes of fifteen bacteria, four archaea and one eukaryote were searched for interkingdom gene fusions; genes coding for proteins that apparently consist of domains originating from different primary kingdoms. The results of this comparative genome analysis show that interkingdom gene fusion is a real ...evolutionary phenomenon"
�Interkingdom gene fusions.� Genome Biol. 2000;1(6):RESEARCH0013. Wolf YI, Kondrashov AS, Koonin EV. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rockville Pike, Bethesda, MD 20894, USA. PMID: 11178267
"...Mammals possess sophisticated endocrine networks in which hormonal signals modulate hundreds of biological effects such as cell differentiation, reproduction, and immune responses. Disrupting these pathways often leads to dire consequences such as birth defects and cancer.
...beyond regulating the production of bacterial virulence factors, recent studies suggest that autoinducers may also have significant effects on gene expression in host organisms. By studying prokaryotic QS systems, we may better understand the evolution and function of our own hormonal networks, and the ways in which our immune systems distinguish between commensal and infectious bacteria. We've begun to piece together the mechanisms for this inter-kingdom communication..."
�The Language of Bacteria... and Just About Everything Else
Secrets to immune and endocrine function may lie in interkingdom communication�
www.the-scientist.com...
Don't get me wrong soficrow, I can't debate "prion science" intelligently until I know more about it. So I wasn't trying to discredit anything. I have been educated and conditioned to question everything. It's not a political or economic bias, it's just the way I think. It comes from taking too many chemistry/biology/physics courses in my college years.
Originally posted by soficrow�The existence of infectious prions has been acknowledged by Nobel Prize laureates and a world of distinguished scientists. Questioning �prion science� simply exposes economic/political bias. If you wish to do so, it�s certainly your privilege.
Originally posted by engineer
Your OP led me to believe that we were talking about cross-kingdom jumps of infectious microbes ...If you say a microbe mutates and crosses kingdoms, that is a pretty radical claim, wouldn't you agree?
I will have to read your last post again, there may be something I missed, but it'll have to wait till later. Interesting subject though, it sounds like prion science has the potential to help us better understand things like cancer and some neurological and CNS type diseases.
Originally posted by soficrow
Crown gall is a definitive example of a cross-kingdom jump - and the original data is pretty old. Today - genetic modifications are based on the mechanics of cross-kingdom 'jumping.' So please, give me this point. I deserve it.
Originally posted by soficrow...We've got a planet full of microbes that are interracting with chemical contamination, radiation and shifting temperatures. They're mutating fast, some inside of 9 minutes, and now they're breeding across species AND kingdom lines!
Originally posted by soficrow
I waited, got impatient. Decided to respond first. You're right, my interest is in the possible role of infectious prions in disease, and the implications. However, my research shows that prion-related diseases go far beyond "cancer and some neurological and CNS type diseases" - particularly when search parameters are expanded to include "mis-folded proteins" (a standard definition of prions).
...For purposes of discussion, would you care to proceed with the following premises?
1) Infectious prions do exist;
2) Prions are almost impossible to kill - they respond and adapt almost instantaneously to any environmental change including temperature shifts and thus, create new strains;
3) The original and most ubiquitous infectious prion is a mis-folded form of actin, ie., "a-smooth muscle actin" which proliferates, accumulates and causes fibrosis in human diseases like fibromuscular dysplasia, cystic fibrosis, and many more;
4) Via actin pathways in the cell membrane, cytoskeleton and cell nucleus, infectious actin prions can infect or hitch-hike on viruses, bacteria, mycoplasma, spirochetes, fungi, mold and virtually every life form on the planet.
The question: What are the implications of the above described circumstance?
...Are you in? ...Do you need references for the premises or can you roll from there?.
Originally posted by engineer
I happen to subscribe to the belief that we live on a very resilient rock. We may screw it up for ourselves, but it will bounce back like it has always done, and over time a new species will replace us as the "master". I also tend to feel that overpopulation is the prime mover in this. Humans sometimes imagine that we are separate from nature, that we can control it, but that is delusion.
I don't really care about extinctions per se, that has happened throughout the entire time there has been life on earth. What I fear most is the loss of biodiversity. I think we can beat on the rock only up to a point, and the whole thing will come crashing down. I think we may be very close to the point of no return as it is. As we destroy whole ecosystems, we commit ourselves to a future with fewer and fewer options.
Originally posted by engineer
The implications: Well, like you said, they probably play a fundamental role in evolution. I'm not sure we can do anything more than study them. Certainly we are not going to, nor do we want to, eliminate them from nature. In fact, they may be a basic player in the biodiversity of the planet.
One has to wonder just how much we should mess with them, though I am not advocating ignoring the science. But say we identify a prion responsible for, oh, alzheimers disease, and attack it. What would that result be? Would that prion then mutate and cause a more virulent reaction? I can imagine that in some cases it would.
When you consider the way bacteria can respond to antibiotics and create "super strains", you have to admire the resilience that nature has provided her little helpers.
But I suppose we can never turn back, penicillin is here to stay, we are not going to stop immunizing for disease, etc.
Originally posted by SkipShipman
Apparently the current powers do not care enough to save the planet, and otherwise want to line fewer pockets with more and more power and resources. ...Extinction is the product of a defective civilization, not "overpopulation," and other things. The problem is simply a "vested interest syndrome," not one of what is doable by the power of mind and good work.
[edit on 20-11-2004 by SkipShipman]
Originally posted by titian
I don't think it's just an American ignorance though. There is often an economic argument provided for why more is not done to protect the environment. Whether people agree or not, it would increase the cost of most products and services if we safeguarded the environment more during their production. Now, of course, if the ultimate price is the demise of the human race than we could say that no price is too high; but here is where human (and particularly American) greed comes into play. We simply don't want to pay more for products and services. But, naturally most of us want to save the environment.
We can't have our cake and eat it too.
Originally posted by engineer
Even avian influenza is a close call. Humans can be infected by eating a "bad bird", but there are no known cases of sustained transmission among humans.
Maybe I'm picking nits here, but a cross phylum or cross kingdom jump of a pathogen has never been identified to my knowledge.
Originally posted by soficrow
Originally posted by SkipShipman
Apparently the current powers do not care enough to save the planet, and otherwise want to line fewer pockets with more and more power and resources. ...Extinction is the product of a defective civilization, not "overpopulation," and other things. The problem is simply a "vested interest syndrome," not one of what is doable by the power of mind and good work.
[edit on 20-11-2004 by SkipShipman]
Sorry Skip - didn't mean to diss you.
I pretty much agree with these statements - but I suspect the problem is bigger, more complicated and more daunting than most decision-makers are qualified to handle. ...so they buy the wrong rationales and strategies, my most unfavorite being, "Wait for natural immunities to develop." Dumb. Wrong. Uneducated. ...Unnecessary. lol.
Originally posted by niman
While the looming flu pandemic could kill off 1/3 to 1/4 of the world's population ...it would not cause a mass extinction.
Originally posted by SkipShipman
... you are still right that the problems may well be too complex and we may have to just throw in the towel sooner or later.
Originally posted by soficrow
Originally posted by SkipShipman
... you are still right that the problems may well be too complex and we may have to just throw in the towel sooner or later.
Good grief - I did not mean that. ...I think the problem is too complex for CEO's and most elected officials to grapple with - which leaves them at the mercy of 'advisors' who don't represent the interests of ordinary people.
Check the 'good news' link I posted above....
Originally posted by soficrow
Originally posted by niman
While the looming flu pandemic could kill off 1/3 to 1/4 of the world's population ...it would not cause a mass extinction.
True, if the flu pandemic were the only disease on the epidemic radar - but it's not.
Originally posted by soficrow
Skip - so the question is - How do we inform people to create the necessary awareness and impetus? ...I've been experimenting here and find that scary stuff gets hits, but academically accurate (and thus boring) stuff does not... lol
..
Originally posted by Szticks
What if one were to implement tax cuts for "healthy living"? Ie if you take good care of yourself mentally and physically you get a tax cut. I'm positive it could be done.
Originally posted by soficrow
I think it's beyond unconscionable to blame the vicitms under these circumstances.
Originally posted by Szticks
Perhaps I misunderstood, but I did not try to imply to blame any victims of disease. However, it's in your best interest to take your responsibility and do what you can to remain healthy.