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Originally posted by TiredofControlFreaks
reply to post by OccamsRazor04
I don't know what you think providing a link for survival times of HPV and Non-HPV cancer proves?
I believe that it will only be a matter of time until they identify all the strains that cause oral-pharangeal cancer.
We ARE NOT talking about mortality rates for oral-pharangeal cancer. People surviving longer or shorter times in an artifact of the medical treatment they receive.
We are talking about the incidence of oral-pharangeal cancer. How often it happens. How many people get it.
Please try to stay on topic.
And if you keep coming out with things that don't address the initial post - then I will do the same thing I did before. Just stop talking to you because you just aren't making sense.
Tired of Control Freaks
Doctors and scientists can’t say for sure what causes each case of oral cavity or oropharyngeal cancer. But they do know many of the risk factors (see “What are the risk factors for oral cavity and oropharyngeal cancers?”) and how some of them cause cells to become cancerous.
In human papilloma virus (HPV) infections, the virus causes cells to make 2 proteins known as E6 and E7. When these are made, they turn off some genes that normally help keep cell growth in check. Uncontrolled cell growth may in some cases lead to cancer. When HPV DNA is found in the tumor cells, especially in non-smokers who drink little or no alcohol, HPV is thought to be the likely cause of the cancer.
In human papilloma virus (HPV) infections, the virus causes cells to make 2 proteins known as E6 and E7. When these are made, they turn off some genes that normally help keep cell growth in check. Uncontrolled cell growth may in some cases lead to cancer. When HPV DNA is found in the tumor cells, especially in non-smokers who drink little or no alcohol, HPV is thought to be the likely cause of the cancer.
CONCLUSION: Increases in the population-level incidence and survival of oropharyngeal cancers in the United States since 1984 are caused by HPV infection.
Q. How fast are HPV-related cancers growing? A. The proportion of HPV-related oral tumors has grown from 16% of all oral cancers in 1984 to 1989, to 72% of these tumors from 2000 to 2004, according to a January report from the American Cancer Society and Centers for Disease Control and Prevention.
HPV is thought to be the likely cause of the cancer
The UW study, published in the Aug. 8 issue of Nature, pieced together the complicated insertion of the human papillomavirus, or HPV, genome, which contains its own set of cancer genes, into Lacks’ genome near an “oncogene,” a naturally occurring gene that can cause cancer when altered. The researchers showed that the proximity of the scrambled HPV genome and the oncogene resulted in its activation, potentially explaining the aggressiveness of both Lacks’ cancer and the HeLa cell line.
This was in a sense a perfect storm of what can go wrong in a cell,” said Andrew Adey, a PhD student in genome sciences at UW and a co-first author on the study. “The HPV virus inserted into her genome in what might be the worst possible way.”
Nobel-Winning Discovery of HPV–Cervical Cancer Link Already Having an Impact on Medicine
Originally posted by TiredofControlFreaks
reply to post by peter vlar
peter vlar:
Please re-read the thread. I have stated a number of times AND have posted link indicating that the type of cancer that occurs at the front of the tongue has not yet been linked to HPV and are still considered to be tobacco related. That there is still 28 % of oral-pharangeal that, to date, are considered to be HPV negative. I even posted a link
What else would you like me to do?
Read the original post. I have stated that despite the decrease in the smoking rate since the 1960s, there has been NO decrease in oral-pharangeal cancers. I have posted links over and over again showing that the medical community has stated that there has been a decrease is tobacco related OP cancer but that there has been a dramatic increase in HPV related cancer since the 1980s due to people having more oral sex.
according to the data you linked and other articles I've read the number of heavy smokers, 20 cigarettes or more per day has decreased. it doesn't actually mean that they've all quit smoking, they've simply cut back to less than a pack per day. the carcinogens still damage DNA whether its 1/3 a pack or 2 packs. it's pretty much cherry picking data to fit the context you wish to present. as for what else I'd have you do... take your own advice and read over the data your quoting a few more times.
[The question I have posed is: how can they say that there has been a dramatic increase in HPV related oral-cancers since the 1980s due to people having more oral sex, when they don't know that the baseline rate of HPV related oral-pharangeal cancers prior to 1980s because they did not know that HPV could cause cancer before the 1980s.
OK... Since the 80's means just what it says, since 1980 or after thus data from before 1980 is irrelevant. it doesn't say since 1965. that means the base year for the data is 1980 and they then track the data from that point forward.
Now just exactly what more do you want from me? How many times must I say the same thing only to have you pop up and say things like this?
Tired of Control Freaks
Until you start making sense
Originally posted by TiredofControlFreaksSo they inserted HPV into a human cell and watched the cancer develop. That is PROOF that HPV CAUSES cancer. Not Correlation - CAUSATION!
Originally posted by TiredofControlFreaks
Why is tobacco always included with alcohol in any study related to oral-pharangeal cancer? Why have they not done a study comparing smokers who DON'T drink with those who DO drink to determine how often oral-pharangeal cancers occur in smokers versus drinkers?
Tired of Control Freaks
Smoking and drinking are independently and synergistically associated with an increased risk of oral cancer, and the risks tend to increase with an increased frequency of exposure.
Originally posted by TiredofControlFreaks
reply to post by peter vlar
Peter Vlar
1. Just because they call a cancer "tobacco-related" does not mean that smoking actually caused the cancer. It really means that they don't know what caused the cancer but since that cancer occurs more in smokers then never-smokers, they assume that the cancer was caused by smoking!
3. in the 1960s and 1970s, epidemiology found that oral-pharangeal cancers occurred more in smoker than non-smokers. Seven times more. They decided that this correlation really meant causation and started putting pictures in ads and on our cigarette pictures of people with holes in their throat to let people know that oral-pharangeal cancers was caused by smoking.
4. Based on this information as well as other cancer scares, people started quitting smoking in droves.
5. |n the 1980s, a scientist proved that the certain strains of HPV caused cancer.
6. Today, almost 50 years later, the rate of smoking in the population is about 25 %. But the incidence rate of oral-pharangeal cancer has not decreased. The medical community now announces that 72 % of all oral-pharangeal cancers is now caused by HPV. This is proven by being able to find fragments of HPV in the tumors. They have as yet, been unable to find the strain of HPV that causes cancers at the front of the tongue. Therefore, they continue to blame HPV negative oral-pharangeal cancer as be caused by cancer.
7. They have yet to prove that smoking causes any cancer. The only evidence still only consists of epidemiology, a soft social science that can be used to highlight correlation but should not be confused as proof of causation.
8. The medical community announces that HPV positive oral-pharangeal cancers have increased dramatically since the 1980s but never mention that they have no baseline rate for the incidence of HPV positive cancer before 1980s.
This is the sequence of events. These are the facts.
If they don't make sense to you...well the only way it makes sense to me is to assume they are lying because they don't want to announce that smoking DOES NOT cause oral-pharangeal cancers and they were wrong.
Tired of Control Freaks
Originally posted by TiredofControlFreaks
reply to post by OccamsRazor04
Well then OccamsRazor04 - we are going to have to agree to disagree!
I am fairly confident that new information will be coming soon.
Tired of Control Freaks
Originally posted by TiredofControlFreaks
reply to post by OccamsRazor04
Well then OccamsRazor04 - we are going to have to agree to disagree!
I am fairly confident that new information will be coming soon.
Tired of Control Freaks