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Neurotoxicol Teratol. 1995 Mar-Apr;17(2):169-77.
Neurotoxicity of sodium fluoride in rats.
Mullenix PJ, Denbesten PK, Schunior A, Kernan WJ.
Toxicology Department, Forsyth Research Institute, Boston, MA 02115, USA.
Abstract
Fluoride (F) is known to affect mineralizing tissues, but effects upon the developing brain have not been previously considered. This study in Sprague-Dawley rats compares behavior, body weight, plasma and brain F levels after sodium fluoride (NaF) exposures during late gestation, at weaning or in adults. For prenatal exposures, dams received injections (SC) of 0.13 mg/kg NaF or saline on gestational days 14-18 or 17-19. Weanlings received drinking water containing 0, 75, 100, or 125 ppm F for 6 or 20 weeks, and 3 month-old adults received water containing 100 ppm F for 6 weeks. Behavior was tested in a computer pattern recognition system that classified acts in a novel environment and quantified act initiations, total times and time structures. Fluoride exposures caused sex- and dose-specific behavioral deficits with a common pattern. Males were most sensitive to prenatal day 17-19 exposure, whereas females were more sensitive to weanling and adult exposures. After fluoride ingestion, the severity of the effect on behavior increased directly with plasma F levels and F concentrations in specific brain regions. Such association is important considering that plasma levels in this rat model (0.059 to 0.640 ppm F) are similar to those reported in humans exposed to high levels of fluoride.
PMID: 7760776 [PubMed - indexed for MEDLINE]
Which means you could technically get at least 8 ppm even more at the usage of the 1ppm in 80% of what you consume daily..
Originally posted by Phage
reply to post by VeritasAequitas
Which means you could technically get at least 8 ppm even more at the usage of the 1ppm in 80% of what you consume daily..
8 ppm. Really? But I don't really understand what you mean when you say "usage of the 1ppm in 80% of what you consume". That doesn't represent a "dose", it's a concentration.
So what you are saying is that if I ate a 12oz can of spam (not that I would) I would be ingesting 2.72mg of fluoride? Can you tell me how you arrive at that 8 ppm figure?
Don't get me wrong. I think that eating a lot of processed food is not a good idea. Nor do I think drinking a lot of water with high concentrations of fluoride (or some other things) is a good idea.
Similar plasma fluoride levels of 0.076-0.25 ppm have been found in humans ingesting 5-10ppm fluoride in drinking water.
Thus, conclusions concerning the neurotoxic potential of fluoride require further rat and human studies, both focused on the relationship of plasma fluoride levels with the brain, behavior, and skeletal growth.
So then why are you defending it?
Originally posted by VeritasAequitas
reply to post by Phage
I'm saying that if they allow 1ppm and this same dosage/concentration is in all of your processed foods etc; so for every can of veggies or chips, spam, etc you are getting 1 ppm per item. Consuming up to 8 processed foods would result in the ingestion of 8 ppm of fluoride; not to mention that quite a few people drink much more than 1L of water or that boiling the water increases the concentration of fluoride.
Consuming up to 8 processed foods would result in the ingestion of 8 ppm of fluoride
not to mention that quite a few people drink much more than 1L of water or that boiling the water increases the concentration of fluoride.
Originally posted by Phage
reply to post by VeritasAequitas
Consuming up to 8 processed foods would result in the ingestion of 8 ppm of fluoride
No. It would result in eating 8 "servings" at 1 ppm (assuming that the "serving" was nothing but water and that water was tap water from a fluoridated water supply).
not to mention that quite a few people drink much more than 1L of water or that boiling the water increases the concentration of fluoride.
Yes they do drink more than 1 liter of water a day. Yes, boiling water does increase the concentration. If you increase the concentration from 1 to 8ppm you have boiled that 1 liter down to 1/8 liter, about 4 ounces. That's a lot of boiling.
It does say fluoride is a neurotoxin, quite blatantly at that, in its title. Only if the results turned out to be negative, then you'd be correct, but you aren't.
What does the EPA limit of 4 ppm say to you, when the lower range of 5 ppm is just 1 ppm away?
Tap water? Then you would get 1/3 more fluoride.
And what if I drink 3L a day
It would depend on how much tap water you added.
and boil water to cook my processed mac and cheese in
Your arguments simply do not make sense. You are trying to present the numbers as harmless instead of taking a cold hard look at ALL the data and making an informed decision.
I rather wish somebody would knock out all of your teeth, then perhaps you wouldn't feel the need to consume fluoride and just maybe you would begin to think clearly.
It was a study of neurotoxicity of sodium fluoride in rats that is what the title means. If the results had turned out negative the title would have been the same and the conclusion would have been that there is no indication of neurotoxicity of sodium fluoride in rats. Instead the result is that at high plasma levels there were indicators of neurotoxicity in rats.
No. It is quite different from what you said. You said the title stated that fluoride is a neurotoxin. The title merely states the object of the experiment.
Above is simply a repeat of what I replied to you, worded differently.
That was confirmed by the recent CDC release that Dental Fluorosis is on the RISE, with increasing percentage.
Are you trying to word your way out of admitting it's a neurotoxin?