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Originally posted by marg6043
reply to post by VneZonyDostupa
Thanks for the tip dear but sadly is hard to find doctors this days that will be willing to work for you best interest and not those of their pockets.
I have been around long enough to remember when doctors used to come to our homes and be friends first and doctors second, when alternative medicine was mixed with modern medicine
and I have seen the transition from what used to be a family doctor that knew you from birth
to the type of doctor today that their priority is to prescribe drugs and ask for symptoms later.
Prions aren't inherited. Prion DISORDERS are inherited
and these are not environmental.
For example, Mad Cow Disease (Creutzfeld-Jakob Disease) is a prion disease. It has never, and will never, show inheritance.
Prion diseases ....can be sporadic (spontaneous), familial (genetic/inherited) or acquired (transmitted by infection).
Please explain exactly how prion disorders are inherited, with references of course.
Not sure where you get your information. This rather basic and sanitized info comes from the USA's National Prion Disease Pathology Surveillance Center:
FYI - sporadic refers to the prions that arise spontaneously in response to environmental "perturbations"
; familial accommodates both genetic and epigenetic inheritance; and acquired includes foodborne and airborne infections, .
but usually refers to infections that are medically acquired, for example in surgery, blood, or transplanted body parts
I'm not certain you understand how genetics works. Every mutation in a coding gene causes a change in the protein it produces.
Environmental toxins wouldn't produce enough misfolded protein in this instance.
Not sure what you think my definition of epigenetic is
I'm basing it purely on what you called "epigenetic" several posts back. If your own words aren't what you meant, you should change them.
however, far more frequently, common chemical exposures cause proteins to misfold and become infectious
Source please.
…environmental insults, either physical (heat, pressure, radiation) or chemical (heavy metals, arsenate, toxins), also cause proteins to misfold into toxic shapes.
….
….conditions that are likely to put stress on proteins and cause them to misfold - such as preexisting misfolded proteins, oxidation, or heat
For example, Mad Cow Disease (Creutzfeld-Jakob Disease) is a prion disease. It has never, and will never, show inheritance.
Creutzfeldt-Jakob Disease (CJD) is the most common of the human prion diseases. There are three types of CJD: 1) sporadic, also called spontaneous, for which the cause is not known; 2) familial, also called genetic or inherited, which is due to a defect in the prion protein gene; 3) and acquired, which is transmitted by infection due to exposure to the infectious prion from contaminated meat, or from transplant of contaminated tissues or use of contaminated instruments during surgical procedures.[/url]
Can you prove Mad Cow isn't a prion disease and isn't transmissible?
FYI - sporadic refers to the prions that arise spontaneously in response to environmental "perturbations"
; familial accommodates both genetic and epigenetic inheritance; and acquired includes foodborne and airborne infections, .
These are all spectrums of CJD, not Mad Cow (BSE). Mad Cow is a specific, transmissible, form of CJD, which I pointed out.
Again, please read posts before responding.
….As I said - "epigenetically inherited traits resulting from environmental causes, without any changes to the DNA."
Again, you are incorrect. Epigenetic changes DO affect the DNA.
….epigenetics is the study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence – hence the name epi- (Greek: επί- over, above, outer) -genetics. It refers to functionally relevant modifications to the genome that do not involve a change in the nucleotide sequence. Examples of such changes are DNA methylation and histone deacetylation, both of which serving to suppress gene expression without altering the sequence of the silenced genes.
……there is no change in the underlying DNA sequence of the organism;[2] instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently.
In science, one can refer to cellular environment
We really don't, actually. The cellular "environment" has little bearing on the organism. You don't see pathology until it is on the tissue level.
but usually refers to infections that are medically acquired, for example in surgery, blood, or transplanted body parts
This is, in no way, shape, or form, part of the definition of "acquired infections".
Creutzfeldt-Jakob Disease (CJD) is the most common of the human prion diseases. There are three types of CJD: 1) sporadic, also called spontaneous, for which the cause is not known; 2) familial, also called genetic or inherited, which is due to a defect in the prion protein gene; 3) and acquired, which is transmitted by infection due to exposure to the infectious prion from contaminated meat, or from transplant of contaminated tissues or use of contaminated instruments during surgical procedures.
Originally posted by VneZonyDostupa
FACT: Very little is "genetic," and based solely on the genetic code or DNA. Most "dispositions" result from "epigenetics" - including epigenetically inherited traits resulting from environmental causes, without any changes to the DNA.
You are misunderstanding the difference between genetics and epigenetics - not surprising given the HUGE amount of money corporate industry has spent to promote this "misunderstanding."
You're incorrect. Mutations in the genes BRCA1 and BRCA2 increase a woman's risk for both breast and ovarian cancer. ..... It is not epigenetic.
Epigenetics in cancer
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer. The initiation and progression of cancer, traditionally seen as a genetic disease, is now realized to involve epigenetic abnormalities along with genetic alterations. Recent advancements in the rapidly evolving field of cancer epigenetics have shown extensive reprogramming of every component of the epigenetic machinery in cancer including DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. The reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, which is already making progress with the recent FDA approval of three epigenetic drugs for cancer treatment. In this review, we discuss the current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies.
Cancer Genetics & Epigenetics
Cancer initiation and progression are driven by a series of genetic and epigenetic alterations that cause either activation (gain-of-function) of oncogenes, or inactivation (loss-of-function) of tumor suppressor genes, - both accompanied by broad alterations in genome utilization and gene expression programs. ….The field has seen a dramatic shift in the past decade from a pure genetic to a mixed genetic/epigenetic explanation of cancer.
Epigenetics in Cancer
Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins1 or cloned animals2 can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name “the causal interactions between genes and their products, which bring the phenotype into being,”3 epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence.4
The best-known epigenetic marker is DNA methylation. . . .
Sofi, do you think that the propaganda to blame women about contracting cancer because lifestyles could be linked to the big health insurance con business due to the health care reform and that if becoming into effect supposedly no one can be turn down due to pre existing conditions.
Perhaps to open the door for legislation on certain type of chronic diseases, after all when you know that is whores in congress sleeping with big corporate money any laws are done to benefit profiteers while screwing the people.
Originally posted by marg6043
reply to post by Night Star
I am so sorry I missed you post, I will keep you in my mind and send all the positive energy for your well being while in your last treatment, just check for the many ways that you can enhance the benefits of treatment and to avoid unnecessary side effects from radiation, is many ways to do that with natural medicine, you can used both, conventional and natural medicine to get the best benefits and avoid side effects.
My father and father in law are both fighting cancer right now, my father for the last 15 years, my father in law just recently.
They both are following conventional medicine but my father is doing also natural medicine his cancer is very slow growing, so far he enjoy an active and fulfilling life at 76.
edit on 10-12-2011 by marg6043 because: (no reason given)
Originally posted by soficrow
[I responded, Firstly, not all breast and ovarian cancer involves these mutations
Secondly, the so-called "it's genetic" "diagnosis" is most often made based on the gene product (mutant misfolded protein), NOT the gene - and the "it's genetic" diagnosis is actually an assumption. (Meaning some cases are epigenetic - at least in terms of cellular 'inheritance' if not familial.)
I would say many, if not most, result from environmental perturbations, eg., chemical or toxin exposure.
AND ...mutations in these genes account for only 2 to 3 percent of all breast cancers.
Instead of a 12 percent lifetime risk of breast cancer, women with one of these genes have a risk of approximately 60 percent.
Common knowledge but here's a quick pick for your edification:
Wrong again. From US Prion Pathology and Surveillance:
Prion diseases ALL have the ability to be sporadic, familial or acquired.
The DNA itself is not altered - only its products are changed. That's what epigenetic means.
Wrong again. Creutzfeldt-Jakob Disease (CJD) is the most common of the human prion diseases. There are three types of CJD: 1) sporadic, also called spontaneous, for which the cause is not known; 2) familial, also called genetic or inherited, which is due to a defect in the prion protein gene; 3) and acquired, which is transmitted by infection due to exposure to the infectious prion from contaminated meat, or from transplant of contaminated tissues or use of contaminated instruments during surgical procedures.