posted on Nov, 12 2011 @ 04:54 PM
Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response
meta-analysis of prospective studies
Our meta-analysis supports an inverse association between intake of dietary fibre, cereal fibre, and whole grains and risk of colorectal cancer,
but we found no significant evidence for an association with intake of fibre from fruit, vegetables, or legumes.
Taking this analysis, especially considering the quality, or lack thereof, of the studies reviewed and making the statement that dietary fiber and
whole grains prevent colorectal cancer is about as ridiculous as taking the above conclusion and saying fruits and vegetables don't help in cancer
prevention.
These types of studies only tell us of an association; there's no arrow of cause. And, as always when we observe cause and effect relationships in
manners such as this, we end up with confounders...which are other associations that may have contributed to the effect...
Higher intakes of dietary fibre and whole grain are typically associated with other health behaviours, such as higher intakes of calcium and
folate; higher levels of physical activity; lower prevalence of smoking, overweight, or obesity; and lower intakes of alcohol and red and processed
meat.
Confounders such as these, if not accounted for, can muddy the water and skew the results quite a bit. And the authors in question had this to
say...
Many but not all of the studies adjusted for potential confounding factors, although not all potential confounders were adjusted for in every
study.
This is a poor quality analysis. However, even if all of the studies in question had adjusted for confounders...there's still no arrow of causation
in observational studies. (and there's quite a bit of error involved with food frequency questionnaire studies, which most of these were) And at
the end of the day, none of this really matters because the analysis still only found...
weak inverse associations between dietary fibre or whole grain intake and risk of colorectal cancer
That's right. It's a weak association that was found. And yet the headlines are reading...
"High-fibre diet cuts bowel cancer risk, analysis of 25 studies finds"
"High-fibre diet cuts bowel cancer risk by a fifth"
"High fibre diets CAN reduce the risk of bowel cancer"
"High Fiber Diet Reduces Colorectal Cancer Risk"
"Colon Cancer Risk Lowered With High-Fiber Diet"
....go figure.