Study Finds Potential Culprit of Alzheimer's Disease

Study Finds Potential Culprit of Alzheimer's Disease

www.edmontonsun.com

Rogue proteins could be responsible for Alzheimer's disease, according to new research out of the University of Alberta.

….the potential culprit in Alzheimer's disease may be the beta amyloid protein.

….Alzheimer's disease and prion disease are the two major neurological diseases.

….The function of the amyloid protein is not entirely known, but (is) related to day to day functions.

(visit the link for the full news article)


Related News Links:
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This study supports previous research linking Alzheimer's, Mad Cow Disease and Type 2 Diabetes, which all involve misfolded or "rogue" proteins. In fact, rogue misfolded proteins are involved in virtually every "modern disease of civilization," aka chronic disease, aka Non-Communicable Disease and the world wide NCD Pandemic.

Proteins are "the building blocks of life." It is well-known and undeniably established that:
1. Proteins respond to environmental change by misfolding, which changes their biological and physical effects on cells and the body;
2. Some misfolded proteins become infectious, causing disease by infecting other proteins;
3. Numerous industrial processes like food processing and drug manufacturing create misfolded proteins;
4. Infectious misfolded proteins use the immune system and nervous systems to move around in the body - such movement is instantaneous, much like the Internet; and
5. As infectious misfolded proteins zip around inside the body and come in contact with new proteins, they can mutate and evolve to infect new proteins, and create different new diseases.

Besides contaminating our food and medicines, misfolded proteins or prions are excreted in feces and urine - which means they're in our soil and water. In addition, research shows prions can be airborne. In short, people are commonly exposed to misfolded proteins and also, to environmental conditions or contaminants that can create new ones. So are other organisms on the planet.

One of the most important research tracks is investigating how prions mutate and evolve to create different diseases as they move through and around the body. The above study looking at the Alzheimer's-Mad Cow disease link falls into this category, as does this one:

Central Nervous System gene expression changes in a transgenic mouse model for Bovine Spongiform Encephalopathy

Gene expression analysis has proven to be a very useful tool to gain knowledge of the factors involved in the pathogenesis of diseases, particularly in the initial or preclinical stages. ….a comprehensive genome wide gene expression study was conducted at different time points of the disease….

Our study reveals changes in the expression of genes, some of them not previously associated with prion diseases, at early stages of the disease previous to the detection of the pathological prion protein, that might have a role in neuronal degeneration and several transcriptional changes showing an important imbalance in the Central Nervous System homeostasis in advanced stages of the disease.

NOTE: "Gene expression" refers to proteins.

It's Not Genetic, It's Epigenetic

Epigenetics: Genome, Meet Your Environment

….In other words, you are what your grandmother ate. But, wait, wouldn't that imply what every good biologist knows is practically scientific heresy: the Lamarckian inheritance of acquired characteristics? ….

EPIGENETICS EXPLAINED
This type of inheritance, the transmission of non-DNA sequence information through either meiosis or mitosis, is known as epigenetic inheritance. From the Greek prefix epi, which means "on" or "over", epigenetic information modulates gene expression without modifying actual DNA sequence.
….

An epigenetic inheritance

It's not just genes that are inherited. Chemical tags that affect gene expression levels may be inherited too….
………..

Also see: Silenced genes drive viral cancers?

There is much proof and little doubt that microbes interact with medicine and drugs to create new disease strains - the pathway is via proteins that respond to environmental change (like drugs in the body) by adapting, mutating and creating new strains. Point being that it's not just humans and animals that get prion diseases, but microbes too. The microbe-prion relationship originally was perceived as prions 'hitchhiking' on microbes - and that may be correct - but in fact, the relationship is more complex. In a microbe-prion relationship, when the prion mutates into a new strain, so does the microbe.

If it makes you feel any better - and it should - this all has been going on for a very long time now - albeit escalating dramatically over the past several years. We really are at the apex - a climax of evolutionary change. I used to be incensed at the deadlocks preventing vaccine production - and at the obstacles to stem cell therapy, which I know to be very advanced. Now, I really do believe that we're better off letting 'nature' handle it.

We have changed our environment - substantially, chemically, biologically and at the molecular level - now it's changing us - something that is necessary for our survival. We are part of the environment - an inextricable part of the larger system - and need to be in harmony with it. Microbes - and prions, and misfolded proteins - are the 'mediators' between complex life and the environment, the larger interrconnected systems we call our planet. So-called 'disease' is simply transition, painful as it may be.

We do NOT know how the natural system works - but we do know that many "diseases" confer immunity to other, far worse diseases. And we know that prions can be very, very good for us. We intervene at our own peril - via ill-conceived "treatments" and vaccines, "mercy killing" or euthanasia policies.

'Good' Prion-Like Proteins Boost Immune Response, Scientists Report

A person's ability to battle viruses at the cellular level remarkably resembles the way deadly infectious agents called prions misfold and cluster native proteins to cause disease, UT Southwestern Medical Center researchers report.

This study marks the first discovery of so-called "good" prion-like proteins in human cells and the first to find such proteins involved in innate immunity: the way the body recognizes and responds to threats from viruses or other external agents, said Dr. Zhijian "James" Chen, professor of molecular biology and senior author of the study in the Aug. 5 print edition of the journal Cell.

…."Remarkably, the MAVS proteins behave like prions and effectively convert nearby proteins into aggregates on the mitochondrial membrane," Dr. Chen said. He noted that the aggregates are necessary for the cells to churn out immunity-boosting interferon molecules. When the MAVS activity is blocked, the antiviral defense stops.

It is good to learn how things work; that's science. Unfortunately, the only way scientists can get research funding is to promise their work might lead to a cure or at least, treatment for known and preferably, scary diseases. Wrong goal, wrong focus. The real problem is our environment - and the global economy that's changing our environment, and pushing our biological systems beyond their limits.

However, despite mounting evidence linking industry to the creation and spreading of infectious misfolded proteins around the world in our food, medicine, water and air - and linking environmental contamination with prion diseases and prion-creating conditions - our corporate leaders in the World Economic Forum (WEF) say people make themselves sick. They say sick people are responsible for the financial crisis, not corporate greed. The WEF also says the NCD Pandemic is an "economic issue, not a health issue" - the NCD Pandemic is predicted to cost $47 Trillion by 2030 - $16 Trillion is tagged as losses due to "mental health" and includes Alzheimer's Disease.

So our corporate leaders want us to do a bit of culling - and preferably, to pull the plugs and put people down as soon as they're unable to work in the corporate system, without waiting until the victims are completely incapacitated.

THE GOOD NEWS

Our species evolved in concert with prions and other disease-causing misfolded proteins - we're built to handle it. The trick is to minimize exposure, and do all the right diet-and-lifestyle things. Just remember - it's not your fault if you're sick, and not your fault if you don't get better - but you DO have some power. So figure out how to use it.

Besides getting lots of exercise, stopping smoking and not drinking or doing drugs - add a few "prion propagation inhibitors" to your diet. High on the list are green tea, curry (turmeric with curcumin), and sage.

New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products

Several classes of compounds were represented in the 17 most potent inhibitors, including naturally occurring polyphenols (e.g., tannic acid and tea extracts), phenothiazines, antihistamines, statins, and antimalarial compounds. ...many are either approved human drugs or edible natural products...

Also - inflammation and oxidation help prions propagate. Go big with anti-inflammatories whenever you can - like cinnamon, aspirin. Same with antioxidants - Vitamin C is king.

.....And try not to stress about it - stress is a killer, and actually can create prions. Really.

Don't forget to cuddle, and get the occasional massage. Touch doesn't just relive stress, it creates new, healthy neurons.

Touch stimulates neurogenesis

Mice exposed to novel tactile stimuli produced new immature neurons in the spinal cord, suggesting that neurogenesis may play a role in touch and vice versa

Finally, it seems our most realistic goal is to make it through this stage of our evolutionary process - it's too late to clean up the world - it's already contaminated and chock full of prions. But hopefully, we can get it together and stop creating new prions before our systems are totally overwhelmed - and maybe have a fighting chance to deal with what's already out there.



www.edmontonsun.com
(visit the link for the full news article)

My grandfather had Alzheimer disease. He worked for an industry where he was exposed to heavy metals. My family always thought that THAT had more to do with his disease than genetics. Interesting thread!

Awesomer and awesomer....

Evidently, we are upon the threshold of understanding more about the nature of bio-mechanics than ever.

Molecular geometry has been a relatively cloistered field for some time. Hopefully these indicators and discoveries may lead to a new paradigm for the treatments and prevention of some of the diseases we see surfacing across the planet every day.

I will contribute a bit more later... but I just wanted to say thanks for keeping us alerted to these reports.

I think you mix up a lot of assumptions in with cherry picked data, but overall agree that the environment is screwed up, and industrial civilization is mostly to blame.

What exactly is a prion? Yes, it's a misfolded protein, but how many causes are there for this? Also, is the definition agreed on by experts? (ans: no)

Why can't the cause of misfolded proteins be multi-factorial?

What percentage of prions are industry related?

Why do you say most chronic diseases are prion related? Is this a fact? Can you provide data for this?

Why is it evil greedy corporations meant to depopulate.





I think what these doctors are looking at in many cases is nothing more than ever so small nano-organisms, that they find the need to lump all the noticable effects these cause on our proteins into the label of a "prion".

I'm not sure it's exactly what you make it out to be is all.

Originally posted by soficrow

Study Finds Potential Culprit of Alzheimer's Disease

www.edmontonsun.com

Rogue proteins could be responsible for Alzheimer's disease, according to new research out of the University of Alberta.

….the potential culprit in Alzheimer's disease may be the beta amyloid protein.

….Alzheimer's disease and prion disease are the two major neurological diseases.

….The function of the amyloid protein is not entirely known, but (is) related to day to day functions.

(visit the link for the full news article)


Related News Links:
www.inews880.com

Related AboveTopSecret.com Discussion Threads:
Sick People, Not Corporate Greed, Causing Financial Crisis?
AIDS, Alzheimer's, Cancer - and Mad Cow Prions. What's the Story?
Alzheimer's might be transmissible in similar way as infectious prion diseases: study
Alzheimers a newly found form of Diabetes?

Lol, Prion Disease. Dude they put prions in everything from manufactured food to prescription and OTC medications.

No wonder so many people are getting these degenerative neurological disorders and the funny thing is, no one cares. The world's governments are sanctioning the mass genocide of humanity and everyone else is oblivious to it.

Were so screwed.

How does this relate to chemtrails, aluminium and batrium??

What a nasty disease... As a kid, I watched my grandfather suffer from it for the last 8 years of his life. He was totally demented. But I remember one time, celebrating new-year with the family at my grandmother's house, who took care of him all that time. He was all dressed up fancy and beautiful in a costume, he had those Sinatra blue eyes. We stood around him and everyone was giving him compliments at how wonderful he looked. Of course nobody anticipated some kind of reply but he actually lifted his head, smiled at us and we could just see his eyes twinkling of joy. I get shivers every time I think about that moment...

So my heart goes out to all people suffering from it right now, and the loving people dedicating their lives taking care of them!

And peace to you, Jean... x

I hope this thread can maintain some form of longevity.

My Mother suffers from Alzheimer's Disease, and I'm at wit's end with not being able to provide any thing along a viable explanation as to why she has it.

reply to post by unityemissions

What exactly is a prion? Yes, it's a misfolded protein, but how many causes are there for this? ....Why can't the cause of misfolded proteins be multi-factorial?

As I keep saying. Proteins misfold easily - in response to stress or "environmental perturbations" - including temperature changes, or exposure to chemicals, heavy metals, oxygen or radiation and etc. So yes - multiple factors can cause proteins to misfold. And I'm sure you recognize that the "environmental perturbations" described above are normal byproducts of now-normal industrial processes, and now-common industrial contaminations.

…environmental insults, either physical (heat, pressure, radiation) or chemical (heavy metals, arsenate, toxins), also cause proteins to misfold into toxic shapes.
….

….conditions that are likely to put stress on proteins and cause them to misfold - such as preexisting misfolded proteins, oxidation, or heat

In fact, prions are evolutionary mechanisms - normal proteins misfold in response to environmental change, become infectious, share the adaptive benefits. It's brilliant, really.

But because of the constant barrage, we're overloaded - and now in the middle of the NCD Pandemic - most of which (arguably) results from industrial processes and contaminations, and the direct or indirect creation of prions. …..Radiation exposure from damaged nuclear plants has and is going to result in a raft of diseases related to protein-misfolding - some of which, like sickle-cell disease, are going to confer evolutionary benefits.

BUT - our corporate rulers -and their shills- insist that we view all these new diseases as resulting from bad lifestyle and diet - as genetic problems, NOT evolutionary solutions - and to focus on the economic situation, the monetary cost.

Big mistake.

The push is on to justify euthanasia for Alzheimer's and dementias. What's next? Are we being manipulated into killing off and quarantining the humans that carry the evolutionary adaptations that will save our species? Out of ignorance? Because collectively we can't deal with the idea of misfolded proteins and prions?

Koch's Principles are obsolete. Get over it.

What percentage of prions are industry related?

Who knows? Can you think of any corporation, agency or organization that might cough up the cash for the required study?

Why do you say most chronic diseases are prion related? Is this a fact? Can you provide data for this?

The 4 main chronic diseases are categorized as 1. cancer, 2. heart disease, 3. Type 2 Diabetes and 4. respiratory disorders - ALL are linked to misfolded proteins.

Lists of Proteopathies, Protein Misfolding Diseases And from the top:

1. Prions are infectious misfolded proteins. There is NO doubt that a protein's shape determines its function and effect. It's very basic stuff.

The function of a protein is determined by its shape.
**

Identifying a protein's shape, or structure, is key to understanding its biological function and its role in health and disease.
**

The structure of a protein determines its function.

2. The disease-causing effects of mishapen or misfolded proteins are indisputable.

For example, when the tau protein misfolds in a way that causes cellular toxicity, Alzheimer's results; but when the tau protein misfolds into a shape that results in gain or loss of function, it causes frontotemporal dementia. Similarly, when amylin misfolds to cause cellular toxicity, that causes Type 2 Diabetes; when a-synuclein misfolds in a way that causes gain of function, Parkinson's results.

Proper protein folding underlies proper protein function, since protein function is dependent on its proper three-dimensional conformation…. Misfolded proteins underlie a great number of cellular pathologies, such as amyloid fibrillogenesis (Alzheimer's), transmissible spongiform encephalopaties (prions), polyglutamine diseases (Huntington's), Parkinsons's lung emphysema (α1-antitrypsin), cystic fibrosis.

...........continued..................

...........post continued from above............

Errors in protein synthesis disrupt cellular fitness, cause disease phenotypes and shape gene and genome evolution. ….Evolutionary responses to errors fall into two broad categories: adaptations that minimize errors and their attendant costs and adaptations that exploit errors for the organism's benefit.
**

…crossbeta structure conformation comprising aggregates underlie various diseases, such as for instance Huntington's disease, amyloidosis type disease, atherosclerosis, diabetes, bleeding, thrombosis, cancer, sepsis, inflammatory diseases, rheumatoid arthritis, transmissible spongiform encephalopathies such as Creutzfeldt-Jakob disease, Multiple Sclerosis, auto-immune diseases, diseases associated with loss of memory such as Alzheimer's disease, Parkinson's disease and other neuronal diseases (epilepsy), encephalopathy, encephalitis, cataract and systemic amyloidoses. ….

A misfolded protein is defined herein as a protein with a structure other than a native, non-amyloid, non-crossbeta structure. ….At present (2007) over 30 misfolding diseases, …have been described as such.
**

"These folded shapes are immensely important because they can define a protein's function in the cell," ….

….some protein shapes fit perfectly into cell receptors, turning chemical processes on and off, like a key in a lock. ….changing the shape of proteins, ….the key might no longer fit into the lock, and serious consequences in the body can occur when proteins fail to assume their preordained shapes or fail to connect properly.

"Misguided proteins have been linked to disease such as cancer, arthritis and wound healing, among others," LeDuc said. "Our research is looking at how protein shapes affect cells and how cell biomechanics impacts the entire process."
**

…wrongly folded proteins are involved in the development of many diseases.
**

Polymers of misfolded proteins underlie many diseases, including major neurodegenerative disorders. ….a range of disorders caused by misfolded proteins.

So there really is no question that protein misfolding "problems" underlie most chronic disease, or NCDs.

….We know prions are created when proteins' environments are "perturbed." Numerous conditions can interefere with normal protein folding, and lead to disease-causing misfolded proteins. However, the earliest, most studied and best proved environmental perturbations that create prions include elevated temperatures, oxidative stress, and heavy metals (Lindquist 1986; Lindquist and Craig 1988).

It is well-known that numerous industrial activities: 1) expose normal proteins to elevated temperatures, oxidative stress, and heavy metals; 2) create misfolded proteins, which can become infectious prions; and 3) cause disease. Not the least of these are drug and vaccine manufacturing and as well, food processing. In addition, prion diseases cross species barriers, and infect humans. Moreover, prions are present in bodily fluids and excretions, and therefor, also present in our water supplies, not just blood products and body parts. All old news, but more recently Aguzzi proved prions also can be airborne.

So - we are exposed routinely to already-created prions in our food, water and possibly, air - not to mention our medical care.

Why is it evil greedy corporations meant to depopulate.

Evil greedy corporations are looking for profit - they just don't give a # that depopulation is part of the package.

I'm not sure it's exactly what you make it out to be is all.

It's more.

reply to post by unityemissions

I think you mix up a lot of assumptions in with cherry picked data,

Unlike you, who doesn't provide links or data at all, cherry picked or otherwise.

but overall agree that the environment is screwed up, and industrial civilization is mostly to blame.

There is still hope for you.

The a-beta amyloid structure found in Alzheimer's patients has a unique tertiary structure and a specific molecular weight that differs from people without the disease.
The rogue a-beta amyloid also has been shown to cause a "complement cascade" that is involved with cellular degridation and has close ties with the immune system in terms of cell distruction.

My 2 cents.

Read on Alan Roses research on the topic if interested.

beez

reply to post by beezzer


Thanks beezer - the complement "cascades" are interesting. Did you know prions hijack the cells' machinery (membranes) to create lipids like cholesterol for use in propagation?

...I'll check out Alan Roses

reply to post by soficrow
Interesting on prions.

While you're at it, might want to check out Dr. Chi-Ming Lee as well.

I worked with him for quite a few years, his work is awesome.

reply to post by beezzer


Thanks again. ...Are you familiar with Aguzzi's and Lindquist's work? How about others who are investigating the role of prions/misfolded proteins as an evolutionary mechanism?

...Did some quick scanning on Roses and Chi-Ming Lee - will need more time for review. But am concerned about that nano-tech approach. Fraught with dangers, imho.

reply to post by soficrow
My work never carried over into prion studies. I was more focused on the endocrine system and how it related to developmental neurobiology and the complement cascade.