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….Ninety per cent of us will die of protracted illness, according to a recent study, and chronic diseases such as cancer and Alzheimer’s will account for about 70 per cent of all deaths.
….Planning for death is …wrongly lumped into contentious debates over euthanasia and suicide – as if… we’re… providing an excuse for caretakers to pull the plug.
.…A living will doesn’t stand in for consent, although physicians have an ethical obligation to honour patients’ wishes within legal limits.
...it has always been accepted that folded protein, not the gene, directly transmits inherited information into biological activity.
...At least the referenced article might help continue the demise of the genomics era so we can return to the study of disease, and not merely focus on the inheritance of stored information.
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A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals
…..misfolding of therapeutic proteins is an immunogenic signal and a risk factor for immunogenicity. ……Over the past decades, the use of therapeutic proteins has become common practice in medicine ……
Protein misfolding is an intrinsic and problematic property of proteins, which underlies a variety of degenerative diseases, such as Alzheimer disease. ….
……experiments pointed out that biopharmaceuticals, like any other protein, are amyloidogenic and that misfolding, detected by amyloid markers, takes place in several preparations. These markers, however, are not necessarily specific for fibrillar amyloid, but also for smaller misfolded protein species.
….. Various Biopharmaceuticals Display Amyloid-like Properties upon Exposure to Conditions of Stress, Indicating Protein Misfolding — During manufacturing and storage, biopharmaceuticals may also become exposed to various conditions of stress that can potentially underlie protein misfolding and the formation of amyloid-like properties.
…….Our results point to a common mechanism by which the immune system perceives misfolded proteins. We hypothesize that this lies in the changed conformation of the protein backbone itself. This implies that the innate immune system may be activated by recognition of the amyloid-like properties of misfolded protein. …
**
The controlled self-assembly of complex molecules into well defined hierarchical structures is a promising route for fabricating nanostructures. These nanoscale structures can be realized by naturally occurring proteins such as tobacco mosaic virus, capsid proteins, tubulin, actin, etc.
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.....Several cell types found on the human skin, including keratinocytes, fibroblasts and lymphocytes, are susceptible to the abnormal infective isoform of the prion protein, which transforms the skin to produce a potential target for prion infection.
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Is Biotech Creating New Incurable Diseases Accidentally?
Even when engineered mutations do not change amino acids, they cause proteins to misfold - which can change the proteins' functions in unexpected ways. Recently released research from the National Cancer Institute in Bethesda, Maryland confirms the misfolding effect, and for the first time, reports finding it in mammals. Misfolded proteins can create incurable diseases, and the phenomenon is causing renewed, but muted concern in the scientific world.
**
Also see:
Did Chemical and Drug Industries Create Mad Cow?
What's killing us? Diseases that will kill 9 of 10 Americans
…..cancer, heart disease, diabetes, and a variety of other chronic ailments. And worse, unlike some infectious diseases, they're quite preventable.
This new, ultra-deadly pandemic threat is caused by we, ourselves. Sedentary lifestyles, poor eating habits, smoking, and other high-risk behavior causes most of these diseases. ….
More than anything, the root causes are apathy and sloth.
Prions are misfolded proteins that transmit diseases such as mad cow. Cashman said the current research doesn't suggest that there is a person-to-person, infectious cause behind ALS or other neurodegenerative diseases such as Alzheimer's and Parkinson's in humans. ….
But he acknowledged the research still raises the spectre of the potential for transmission between individuals since prions are infectious agents and that issue calls for further research.
Chronic disease to cost $47 trillion by 2030: WEF
The global economic impact of the five leading chronic diseases -- cancer, diabetes, mental illness, heart disease, and respiratory disease -- could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). ….
"This is not a health issue, this is an economic issue ….." ……
….Mental health, which is typically left off lists of leading NCDs, will account for $16 trillion -- a third of the overall $47 trillion anticipated costs.
Alzheimer's deterioration may go unnoticed in some seniors
People can have the brain deterioration that comes with Alzheimer's disease without showing debilitating symptoms, a new study finds. ...Researchers in the U.S. studied the brains of 134 clergy who donated their bodies to science. They were in their 80s on average when they died.
None had clinical symptoms of Alzheimer's before they died, but 37 per cent showed lesions on the brain associated with the disease, a research team reported in Tuesday's issue of the journal Neurology.
"It means that a large number of people can accumulate all of this disease pathology and still be functioning very well," said study author Dr. David A. Bennett of the Rush Alzheimer's Disease Center in Chicago.
…Feldman is convinced the brain is a "use-it-or-lose-it" organ. Seniors with a higher education who stay mentally active and socially connected as they age can have the disease without knowing it, he said.
Cancer to be a "Notifiable Disease" in India
Every hospital in India - private or public - may soon be bound to inform government on the number of cancer cases they treat.
The push is in the offing since the Indian Council of Medical Research (ICMR) has recommended to the Union health ministry to make cancer a "notifiable disease".
At present, highly infectious diseases like plague, polio, H5N1 bird flu or the H1N1 swine flu figure in the list. Cancer will become the first non-communicable disease (NCD) to be bracketed under the same category.
In the United States, cancer is likely to affect 1 in 2 men and 1 in 3 women at least once in their lifetime.
People are suffering diseases created and spread by industrial contaminants, activities and technologies that make normal proteins misfold and become infectious. These diseases are now pandemic, bankrupting families, social and health care systems, even nations - and threatening the global corporate economy.
The golf-ball-sized brain tumor appears as a spongy mass inside the skull cavity of a 72-million-year-old Gorgosaurus fossil, now on display at The Children's Museum of Indianapolis in Indiana. The probable tumor would have affected the animal's balance and caused other damage, explaining the many crippling wounds and fractures recorded in her skeleton.
I guess one train of thought is that the more plastic people become the less biologically induced illnesses will have it's affect upon us.
People today tend to inject inorganic compounds into themselves…botox treatment or breast implant
Soon, plastic organs and inorganic body parts of all sorts will become an accepted method of continuity, as the next, best fad washes over us in the form of synthetic hair. What's next?
Induction into the mechanical realm? magnetics to influence our thoughts, our realities, our experiences?
At some point... Inevitably, mankind will become immune to organic invasions, as it will become impossible for these genetic traits to corrupt our hard coded gene pool... either that, or if indeed it still has relevance, we'll find a way to 'back up' our good gene set, and then over write the genetically corrupted malignancy with the very same back up...
...it has always been accepted that folded protein, not the gene, directly transmits inherited information into biological activity.
...At least the referenced article might help continue the demise of the genomics era so we can return to the study of disease, and not merely focus on the inheritance of stored information.
Sickle-cell disease, usually presenting in childhood, occurs more commonly in people (or their descendants) from parts of tropical and sub-tropical regions where malaria is or was common. One-third of all indigenous inhabitants of Sub-Saharan Africa carry the gene,[2] because in areas where malaria is common, there is a fitness benefit in carrying only a single sickle-cell gene (sickle cell trait). Those with only one of the two alleles of the sickle-cell disease, while not totally resistant, are more tolerant to the infection and thus show less severe symptoms when infected.
Lindquist Lab
….We investigate how protein conformational changes provide epigenetic mechanisms of inheritance, sculpt phenotypic landscapes, shape evolutionary process, and cause devastating neurodegenerative diseases. ….One implication of our work is that
the protein-folding problem isn’t always a problem. The very same types of misfoldings that cause dreadful diseases in some circumstances can have beneficial effects in others. The protein-folding problem is as ancient as life itself; it makes sense that evolution would occasionally, perhaps even often, use it to advantage.
Originally posted by projectvxn
reply to post by soficrow
People are suffering diseases created and spread by industrial contaminants, activities and technologies that make normal proteins misfold and become infectious. These diseases are now pandemic, bankrupting families, social and health care systems, even nations - and threatening the global corporate economy.
Are you saying cancer is caused by corporations?
What about this:
First Dinosaur Brain Tumor Found, Experts Suggest
….the protein-folding problem isn’t always a problem. The very same types of misfoldings that cause dreadful diseases in some circumstances can have beneficial effects in others. The protein-folding problem is as ancient as life itself; it makes sense that evolution would occasionally, perhaps even often, use it to advantage.
Or how about the fact that Alzheimer’s disease is the most common cause of dementia among older people. Dementia is something humans have been living with for a very long time as well.
Now I'm not saying that industrial pollution has NO effect on human health. But to place the blame squarely on corporations isn't exactly accurate either.
While contaminants can and will hurt people in the long run, the ailments we face were there before and will be here after such pollution is eradicated.
So what do we do? Perhaps we should focus on how to cure these diseases. Yes, part of that is addressing root causes. But if we misidentify what the root cause is we will come up empty handed when we try to cure it.
Originally posted by Wildmanimal
reply to post by projectvxn
Yes, your right emmisions from naturally occuring Uranium Ore,Radon Gas, and Cosmic Rays,etc. have been
mutating cells here since it all began. But we have certainly increased that low level background radiation
substantially now haven't we. Add to that Chemical emmisions, and Wham-O. Bad Ju Ju.
Funny, last night I was looking into a living will.
I have chronic pain that seems to be getting worse as the years pass. The scary thing is, I am under 30 years of age. I can only imagine what I might feel like when I hit 40, or 50.
…..I don't have this chronic illness because I am sloth or lazy. Before I got "sick" I was in tip top military shape, finished college and had a solid 5 year plan to get into a career and to buy a house. But after two severe recent (physical) traumas that happened relatively close to each other, I was not able to fully recover.
New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products
Several classes of compounds were represented in the 17 most potent inhibitors, including naturally occurring polyphenols (e.g., tannic acid and tea extracts), phenothiazines, antihistamines, statins, and antimalarial compounds. ...many are either approved human drugs or edible natural products...
I could blame the corporations and such, but what good would it do?
One of the reasons I am in constant pain is because of environmental factors, mainly stress. It makes everything worse, and the pain becomes almost intolerable when I get very stressed out. The changes your body goes through when you are under constant stress is crazy. It becomes very physical.
We neglect our human civil rights to die. Suicide and euthanasia or "compassion killings" are so taboo and people refuse to talk about it, even though it's sorely obvious that it is something worth considering, because one day you might have to think about it yourself.
Originally posted by ZeroKnowledge
Pollution is bad. It certainly and significantly increases the chance of cancer and ctr.
Damage to DNA can be caused by natural things, like sun rays or other-reaction of immune system and lots of other things.
But THE leading reason for cancer is still increased life expectancy.
Pollution is bad and we do poison our-self. But this is not a reason to panic, me thinks.
U.S. Halts Long-Term Care Program
The Obama administration said Friday it is unable to implement a long-term care insurance program that was part of the 2010 health overhaul, effectively ending the program before it started.
The initiative, known as the Class Act, was included in the law to help Americans cover the cost of aid for daily-living needs such as bathing and using the toilet if they became unable to care for themselves. Mounting concerns that the program was too costly over the long run had prompted officials at the Department of Health and Human Services to re-examine the program in recent months. Last month, it fired the program's chief actuary and reassigned other staff.