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Several colleagues outside the UK have told me of anonymous telephone calls from individuals acting on behalf of the aluminum industry and warning them that their recent interest in aluminum and health will not be advantageous to their careers. Readers may baulk at such suggestions of cloak-and-dagger activities but should just take a moment to consider the implications of aluminum being unequivocally linked to chronic disease in humans. By comparison, the problems currently faced by the tobacco industry will be very small beer indeed!
Originally posted by Whitbit
Several colleagues outside the UK have told me of anonymous telephone calls from individuals acting on behalf of the aluminum industry and warning them that their recent interest in aluminum and health will not be advantageous to their careers. Readers may baulk at such suggestions of cloak-and-dagger activities but should just take a moment to consider the implications of aluminum being unequivocally linked to chronic disease in humans. By comparison, the problems currently faced by the tobacco industry will be very small beer indeed!
Toxic effects are dependent upon the amount of metal ingested, entry rate, tissue distribution, concentration achieved, and excretion rate.19,20,21,22
Mechanisms of toxicity include inhibition of enzyme activity and protein synthesis, alterations in nucleic acid function, and changes in cell membrane permeability.
In this regard, dietary excitotoxins including aluminum can exacerbate the clinical presentation by worsening of excitotoxicity and by microglial priming. This opens the discussion to the use of nutritional factors that reduce excitotoxicity and brain inflammation as a maneuver to alleviate neurotoxic effects of aluminum.10,11 The central nervous system appears to be extremely sensitive to metal-induced oxidative stress. High aluminum concentrations have been found in postmortem brain specimens of patients with Parkinson's disease and on animals models where administration of aluminum caused a strong decrease in dopamine content of the striatum.12
Unfortunately, physical findings are often noticeably lacking in patients with aluminum toxicity, and findings usually mimic other disease processes.
Aluminum causes an oxidative stress within brain tissue.8 Since the elimination half-life of aluminum from the human brain is 7 years, this can result in cumulative damage via the element's interference with neurofilament axonal transport and neurofilament assembly. Some experts believe it plays a role in leading to the formation of Alzheimer-like neurofibrillary tangles.