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...If...
A: Saturated Fat consumption
=
B: Increased serum cholesterol levels
...and...
B: Increased serum cholesterol levels
=
C: Atherosclerosis (Heart Disease)
...then...
A: Saturated Fat consumption
=
C: Atherosclerosis (Heart Disease)
A longitudinal study is a correlational research study that involves repeated observations of the same items over long periods of time — often many decades. It is a type of observational study.
Saturated fat was unrelated to heart attack risk
Men who died of CHD ate significantly less saturated fat than men who didn't.
Overall, these results tend to support the hypothesis that diet is related, albeit weakly, to the development of coronary heart disease.
Proportional hazards analyses controlling for total energy intake indicated that increasing percentages of energy intake as total fat (RR 1.04, 95% CI = 1.01-1.08), saturated fat (RR 1.11, CI = 1.04-1.18), and monounsaturated fat (RR 1.08, CI = 1.01-1.16) were significant risk factors for CHD mortality among 30 to 59 year olds. The increasing percentage of energy intake from carbohydrate had a significant protective effect (RR 0.96, CI = 0.94-0.99)
A fat diet, rich in saturated fatty acids (SFA) and low in polyunsaturated fatty acids (PUFA), is said to be an important cause of atherosclerosis and cardiovascular diseases (CVD). The evidence for this hypothesis was sought by reviewing studies of the direct link between dietary fats and atherosclerotic vascular disease in human beings. The review included ecological, dynamic population, cross-sectional, cohort, and case-control studies, as well as controlled, randomized trials of the effect of fat reduction alone.
The harmful effect of dietary SFA and the protective effect of dietary PUFA on atherosclerosis and CVD are questioned.
METHODS: We conducted a systematic search of MEDLINE for prospective cohort studies or randomized trials investigating dietary exposures in relation to CHD. We used the Bradford Hill guidelines to derive a causation score based on 4 criteria (strength, consistency, temporality, and coherence) for each dietary exposure in cohort studies and examined for consistency with the findings of randomized trials.
CONCLUSIONS: The evidence supports a valid association of a limited number of dietary factors and dietary patterns with CHD. Future evaluation of dietary patterns, including their nutrient and food components, in cohort studies and randomized trials is recommended.
Originally posted by DrumsRfun
1.What do you think of Monsanto and do you think they got their FDA approval rating fair and square?
2.Is it fact or fiction that even on a diet you can still eat eggs and bacon every morning?
Originally posted by soficrow
reply to post by DevolutionEvolvd
EXCELLENT work. S&F.
Transfat is another story though, right?
...and maybe the changing composition of 'fat' or perhaps some pesky little hitchhikers?
BUT - in the end - seems the data get skewed to "prove" people make themselves sick...
Not true and not really fair, is it?
Originally posted by DevolutionEvolvd
Originally posted by soficrow
reply to post by DevolutionEvolvd
...and maybe the changing composition of 'fat' or perhaps some pesky little hitchhikers?
Are you refering to rancidity/oxidation?
Lipid rafts are dynamic assemblies of proteins and lipids (fats) … we give some examples of how rafts contribute to our understanding of the pathogenesis of different diseases. …Rafts are small platforms, composed of sphingolipids and cholesterol in the outer exoplasmic leaflet, connected to phospholipids and cholesterol in the inner cytoplasmic leaflet of the lipid bilayer. …How lipid rafts promote abnormal prion conversion is not clear.
The prion diseases are unique in that their infectious nature is not dependent on nucleic acid but is instead attributed to a misfolded protein, the prion protein. This misfolded prion protein is capable of inducing the misfolding of the normal form of the prion protein that is present on the surface of neurons and other cells in the body. However, the site in the cell at which this misfolding occurs and whether other proteins are involved remains controversial. We have addressed these questions by investigating how the normal form of the prion protein is targeted to specialised domains on the plasma membrane termed cholesterol-rich lipid (fat) rafts.
The prion protein and lipid rafts
Lipid rafts appear to be involved in the conformational conversion of PrPC to PrPSc, possibly by providing a favourable environment for this process to occur and enabling disease progression.
BUT - in the end - seems the data get skewed to "prove" people make themselves sick...
Not true and not really fair, is it?
What's not fair is human nature: It's almost impossible to be completely objective without bias.....as a researcher.
Originally posted by nh_ee
Interesting in that one aspect of commonality amongst the Mediterranean is the consumption of Red Wine for a nutrient found in skins of the grapes used in making red wine has been proven to have a lot to do with this.
b. 'cuz even though they created the situation, they have no idea how to fix it.
A Longitudinal Study of Coronary Heart Disease
Diet and heart: a postscript
Relationship of dietary intake to subsequent coronary heart disease incidence: The Puerto Rico Heart Health Program
Diet, Serum Cholesterol, and Death from Coronary Heart Disease — The Western Electric Study
Diet and 20-y mortality in two rural population groups of middle-aged men in Italy
Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
The abstract in the study above is misleading. Scroll down to table 2 and you'll see that when other risk factors are included the correlation vanishes.
Dietary Fat
Intake and the Risk of Coronary Heart Disease in Women
Dietary fat intake and early mortality patterns – data from The Malmö Diet and Cancer Study
That's 9 studies and two graphs from NHANES data that show no association between saturated fat intake and heart disease risk. There are plenty more. I mean, if saturated fat is the devil, like we're told, then why do the best studies we have demostrate no detectable effects?
Why aren't people who consume large amounts of saturted fat croaking of heart attacks left and right?
The general consensus is part "A" is fact. Part "B" is that increasing total serum cholesterol/LDL increases heart disease risk.
Now, this is where you ask yourself the question...Why are we told to avoid saturated fat when, clearly, the evidence supporting such a recommendation is severely lacking
Who's responsible? Is it the prevalence of Industry support (big pharma, big food); is it consequence of politics dipping its pen into science (public health policy); or is it simply that a few scientists made honest mistakes, initiated by confirmation bias, and the idea just stuck, dogma?
Originally posted by VneZonyDostupa
There's no real profit to be made in saturated fats versus unsaturated, so I doubt "big food" is involved, nor is there any money to be made by Pharma
Originally posted by soleprobe
Originally posted by VneZonyDostupa
There's no real profit to be made in saturated fats versus unsaturated, so I doubt "big food" is involved, nor is there any money to be made by Pharma
Just by skimming through your post and catching the above statement I don't have to read the rest regardless of the "amount of work" you put into it.
Originally posted by VneZonyDostupa
You seem to be pretty certain that saturated fats are the big money-maker, so surely you have some data to support this...right?
Originally posted by VneZonyDostupa
reply to post by soleprobe
People will still develop CAD regardless of whether you tell them it is caused by saturated fat, cholesterol, water, air, or simply existing. People don't tend to like diet and exercise, as it requires effort on their part.
... I'm an atheist, ...
Originally posted by soleprobe
If people continue to follow the advice of the medical industrial complex regarding diet they certainly will develop CAD and a host of other diseases even if they exercise. The trillion dollar medical industrial complex is in the business of disease creation and treatment.
As for you being an atheist I’m not surprised.
Originally posted by VneZonyDostupa
You think following the advice of "eat mostly fruits and vegetables with minor contributions from whole grain carbs and lean meats" is going to cause disease?