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Medscape Today
Coffee Consumption Improves Markers of Inflammation and Oxidative Stress
Coffee and inflammation
March 26 2010
Michael O'Riordan
"We found some evidence of beneficial effects on the lipid profile, but no effects on glucose metabolism," report lead investigator Dr Kerstin Kempf (University Düsseldorf, Germany) and colleagues. "Because subclinical inflammation is a risk factor for type 2 diabetes, our results suggest one mechanism that could mediate the reduced risk of type 2 diabetes among individuals who habitually consume coffee for years."
“Writing in the April 2010 issue of the American Journal of Clinical Nutrition, the researchers add that previous studies have shown that drinking coffee protects against developing type 2 diabetes mellitus, possibly through reductions in inflammation, oxidative stress, and favorable changes in the lipid profile.”
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A small study published this week points again to the beneficial effects of coffee consumption. Researchers showed that drinking coffee led to improved markers of subclinical inflammation and oxidative stress, as well as increases in HDL-cholesterol levels.
"We found some evidence of beneficial effects on the lipid profile, but no effects on glucose metabolism," report lead investigator Dr Kerstin Kempf (University Düsseldorf, Germany) and colleagues."
"Because subclinical inflammation is a risk factor for type 2 diabetes, our results suggest one mechanism that could mediate the reduced risk of type 2 diabetes among individuals who habitually consume coffee for years."
Writing in the April 2010 issue of the American Journal of Clinical Nutrition, the researchers add that previous studies have shown that drinking coffee protects against developing type 2 diabetes mellitus, possibly through reductions in inflammation, oxidative stress, and favorable changes in the lipid profile.
Study of habitual coffee drinkers
In this study of 47 habitual coffee drinkers, the individuals stopped drinking coffee for one month. In the next month, they drank four cups of coffee per day, followed by eight cups of coffee daily in the second month. Subjects were relatively healthy, younger than 65 years of age, but with an increased risk of diabetes based on a diabetes risk score.
After the two months of subjects drinking coffee, the researchers observed significant decreases in markers of subclinical inflammation, including interleukin-18 (IL-18) and adiponectin, but no increases in levels of C-reactive protein (CRP). Markers of oxidative stress, on the other hand, were significantly reduced.
"There was a significant decrease in circulating IL-18 concentrations, but no changes in systemic CRP or IL-6 concentrations," write Kempf and colleagues. "We previously identified higher concentrations of IL-18 as a risk factor for type 2 diabetes."
Regarding the lipid parameters, the researchers report that total-cholesterol levels were significantly increased, by 12%, after the second month of drinking coffee. In addition, apolipoprotein A1 levels were also significantly increased. HDL-cholesterol levels were up 7%, from 48 mg/dL to 51 mg/dL, by the end of the second month.
There were no changes in any markers of glucose metabolism. According to the researchers, this "noteworthy" finding might be explained by the short duration of the trial compared with coffee consumption over years in prospective studies. They say the favorable effects on HDL cholesterol should be investigated further.
www.medscape.com...
Originally posted by BellaMente
Thanks for this, now I have an excuse to drink my average 8 shots of espresso a day without my friend telling me my heart is going to explode!
Originally posted by CoffeeGeek
(at the time i was having about 16-20 shots of espresso a day). I cut back and my blood sugar leveled out. I still have about 12 shots a day. Mmmmmmm....coffee
news.bbc.co.uk...
The protection may not be down to caffeine since decaf coffee has the greatest effect, say researchers in Archives of Internal Medicine.
They looked at 18 separate studies involving nearly 500,000 people.
This analysis revealed that people who drink three or four cups of coffee or tea a day cut their risk by a fifth or more, say researchers.
The same amount of decaffeinated coffee had an even bigger effect, lowering risk by a third.
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Type 2 diabetes is treated with a healthy diet and increased physical activity
Coffee, Decaffeinated Coffee, and Tea Consumption in Relation to Incident Type 2 Diabetes Mellitus
A Systematic Review With Meta-analysis
Rachel Huxley, DPhil; Crystal Man Ying Lee, PhD; Federica Barzi, PhD; Leif Timmermeister; Sebastien Czernichow, MD, PhD; Vlado Perkovic, MD, PhD; Diederick E. Grobbee, MD, PhD; David Batty, PhD; Mark Woodward, PhD
Arch Intern Med. 2009;169(22):2053-2063.
Background:
Coffee consumption has been reported to be inversely associated with risk of type 2 diabetes mellitus. Similar associations have also been reported for decaffeinated coffee and tea. We report herein the findings of meta-analyses for the association between coffee, decaffeinated coffee, and tea consumption with risk of diabetes.
Methods:
Relevant studies were identified through search engines using a combined text word and MeSH (Medical Subject Headings) search strategy. Prospective studies that reported an estimate of the association between coffee, decaffeinated coffee, or tea with incident diabetes between 1966 and July 2009.
Results:
Data from 18 studies with information on 457 922 participants reported on the association between coffee consumption and diabetes. Six (N = 225 516) and 7 studies (N = 286 701) also reported estimates of the association between decaffeinated coffee and tea with diabetes, respectively. We found an inverse log-linear relationship between coffee consumption and subsequent risk of diabetes such that every additional cup of coffee consumed in a day was associated with a 7% reduction in the excess risk of diabetes relative risk, 0.93 [95% confidence interval, 0.91-0.95]) after adjustment for potential confounders.
Conclusions:
Owing to the presence of small-study bias, our results may represent an overestimate of the true magnitude of the association. Similar significant and inverse associations were observed with decaffeinated coffee and tea and risk of incident diabetes. High intakes of coffee, decaffeinated coffee, and tea are associated with reduced risk of diabetes. The putative protective effects of these beverages warrant further investigation in randomized trials.
archinte.ama-assn.org...
Originally posted by BellaMente
Thanks for this, now I have an excuse to drink my average 8 shots of espresso a day without my friend telling me my heart is going to explode!
Originally posted by CavemanDD
That's interesting but i'd like to know if it applies to de-caffinated coffee.
Originally posted by doped00
My papa bear (who is now 50) drinks coffee all day long. I would guess maybe 10-12 cups and not only that, but due to work averages 5 hours of sleep a night for the past 7 years and is healthy as a horse. Shoot, he'll have a cup right before bed.