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Preliminary research suggests the seasonal flu shot may put people at greater risk for getting swine flu, CBC News has learned.
"This is some evidence that has been floated; it hasn't been validated yet, it's very preliminary," cautioned Dr. Don Low, microbiologist in chief at Mount Sinai Hospital in Toronto.
"This is obviously important data to help guide policy decision. How can we best protect people against influenza?"
It's important to validate the information to make sure it's not just a fluke, and that the observation is confirmed elsewhere such as in the Southern Hemisphere, which just completed its seasonal flu season, Low added.
The four Canadian studies involved about 2,000 Canadians in Ontario, Quebec, British Columbia and Alberta, sources told CBC News. Researchers found people who had received the seasonal flu vaccine in the past were more likely to get sick with the H1N1 virus.
Researchers know that theoretically when people are exposed to bacteria or a virus, it can stimulate the immune system to create antibodies that facilitate the entry of another strain of the virus. Dengue fever is one example, Low said.
The four Canadian studies involved about 2,000 Canadians in Ontario, Quebec, British Columbia and Alberta, sources told CBC News. Researchers found people who had received the seasonal flu vaccine in the past were more likely to get sick with the H1N1 virus.
Mixing vaccines
In another development on Thursday, the World Health Organization announced that a panel of experts will look at the unpublished Canadian data that suggests previous seasonal flu shots may put people at greater risk of catching the swine flu virus.
The UN health agency has already contacted researchers worldwide to try to corroborate the preliminary Canadian findings, but the effect has not been seen elsewhere, Marie-Paul Keany, WHO's vaccine research director, told a teleconference with reporters from Geneva.
She praised the Canadian investigators as well known and credible, but noted the new data needs to be reviewed
www.cbc.ca...
On Sunday Quebec joined Alberta, Saskatchewan, Ontario and Nova Scotia in suspending seasonal flu shots for anyone under 65 years of age. Quebec's Health Ministry announced it would postpone vaccinations until January, clearing the autumn months for health professionals to focus on vaccinating against H1N1, which is expected to the more severe influenza strain this season.
[...]
So far, the study's impact is confined to Canada. Researchers in the U.S., Britain and Australia have not reported the same phenomenon. Marie-Paule Kieny, the World Health Organization's director of vaccine research, said last week the Canadian findings were an international anomaly and could constitute a “study bias.”
www.theglobeandmail.com...
The unpublished study suggests that those under 50 years of age are at a higher risk of being infected with the swine flu virus after receiving the annual flu shot.
Details of the study, coupled with skepticism in some quarters about the new H1N1 vaccine, could place territorial and provincial inoculation programs in disarray with fewer people turning up for either shot.
Lead authors, Danuta Skowronski of the British Columbia Centre for Disease Control and Gaston De Serres of Laval University, have submitted their findings to an unnamed scientific journal and may not comment until it is published.
Their paper found that consistency across four epidemiologic studies and one animal experiment suggested "an association that cannot be dismissed on the basis of chance and is unlikely to be explained entirely by bias."
www.theglobeandmail.com...
International influenza vaccine experts are apparently not convinced that Canadian researchers have found a true link between getting a seasonal flu shot and catching swine flu.
The consensus that emerged from a World Health Organization teleconference Friday on the controversial data seemed to be that the Canadian findings are likely due to some confounding factor or factors in the data themselves and may not reflect a real increased risk, according to a WHO official who helped pull together the meeting.
"From a WHO point of view, the fact that the findings are not replicated in other countries I think is reassuring for us that this is an outlier, if you like, the unexpected findings that are coming out of Canada," said David Wood, co-ordinator of the quality, safety and standards team of WHO's department of immunization, vaccines and biologicals.
"Most people are still looking at this as some sort of undetected confounding in the data, that for some reason is giving the results that are there."