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Originally posted by thetruthhurts78
being that i did not read every post on all 23 pages of this epic discussion.
Was it brought up that it could be a little of both? that life could have been created followed by life evolving? just wondering. It is atleast what I would like to believe.
Originally posted by thetruthhurts78
being that i did not read every post on all 23 pages of this epic discussion.
Was it brought up that it could be a little of both? that life could have been created followed by life evolving? just wondering. It is atleast what I would like to believe.
Originally posted by melatonin
Originally posted by GT100FV
Could you cite an example in say a Mammal, Reptile, Fish, Bird, etc.. where a mutation has been a good thing?
I just did.
Here's another:
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Lynn M. Boyden, Ph.D., Junhao Mao, Ph.D., Joseph Belsky, M.D., Lyle Mitzner, M.D., Anita Farhi, R.N., Mary A. Mitnick, Ph.D., Dianqing Wu, Ph.D., Karl Insogna, M.D., and Richard P. Lifton, M.D., Ph.D.
ABSTRACT
Background Osteoporosis is a major public health problem of largely unknown cause. Loss-of-function mutations in the gene for low-density lipoprotein receptor–related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis–pseudoglioma.
Methods We performed genetic and biochemical analyses of a kindred with an autosomal dominant syndrome characterized by high bone density, a wide and deep mandible, and torus palatinus.
Results Genetic analysis revealed linkage of the syndrome to chromosome 11q12–13 (odds of linkage, >1 million to 1), an interval that contains LRP5. Affected members of the kindred had a mutation in this gene, with valine substituted for glycine at codon 171 (LRP5V171). This mutation segregated with the trait in the family and was absent in control subjects. The normal glycine lies in a so-called propeller motif that is highly conserved from fruit flies to humans. Markers of bone resorption were normal in the affected subjects, whereas markers of bone formation such as osteocalcin were markedly elevated. Levels of fibronectin, a known target of signaling by Wnt, a developmental protein, were also elevated. In vitro studies showed that the normal inhibition of Wnt signaling by another protein, Dickkopf-1 (Dkk-1), was defective in the presence of LRP5V171 and that this resulted in increased signaling due to unopposed Wnt activity.
Conclusions The LRP5V171 mutation causes high bone density, with a thickened mandible and torus palatinus, by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling. These findings demonstrate the role of altered LRP5 function in high bone mass and point to Dkk as a potential target for the prevention or treatment of osteoporosis.
content.nejm.org...
ABE: and just to consolidate the point, here's another:
Arterioscler Thromb Vasc Biol 1998 Apr;18(4):562-567.
PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants.
Margaglione M, Cappucci G, d'Addedda M, Colaizzo D, Giuliani N, Vecchione G, Mascolo G, Grandone E, Di Minno G; Unita' di Trombosi e Aterosclerosi, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Abstract:
Plasminogen activator inhibitor-1 (PAI-1) plasma levels have been consistently related to a polymorphism (4G/5G) of the PAI-1 gene. The renin-angiotensin pathway plays a role in the regulation of PAI-1 plasma levels. An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been related to plasma and cellular ACE levels. In 1032 employees (446 men and 586 women; 22 to 66 years old) of a hospital in southern Italy, we investigated the association between PAI-1 4G/5G and the ACE I/D gene variants and plasma PAI-1 antigen levels. None of the individuals enrolled had clinical evidence of atherosclerosis. In univariate analysis, PAI-1 levels were significantly higher in men (P
Originally posted by madnessinmysoul
reply to post by melatonin
we really, really need to get you an official badge or something for stamping out quotmining
anyway, as has been said, there is no evidence whatsoever to support the creationist hypothesis.
Originally posted by saturnine_sweet
The problem with these is one involves alleles, which doesnt add new genetic information, just uses the available genes differently, and a mutation that removed information, which again, doesn't add information. So you're talking natural selection, aka microevolution. That doesnt lead to new species.
Originally posted by saturnine_sweet
ok, there are two schools of thought on the definition of microevolution and macroevolution, so lets just skip the terms and talk processes.
The processes listed in the one involve the loss of information in the genes. That is a reductive mutation. The other is alleles, which is just the rise of a certain gene variant due to environmental stress. The point is, neither adds new genes, IE, new information.
For a definition of information as it applies here, click here. That helps define information in regards to information theory.
In a more practical sense, information is organized data that has meaning. For example, take two blank floppy disks. On one, load a word file. On the other, run a magnet across it randomly. Disk one contains information, disk two contains none.
Another way to think of it, that you might be familiar with, is signal to noise ratio. Information is the same as the signal. Noise is the random variations of whatever medium you are using, that has no meaning or organization. Never will noise turn into signal. You don't tune your radio to an empty band and have the static suddenly organize itself into music.
It relates to thermodynamics, really. Information requires work to create it. Work requires heat (energy.) Heat does not randomly appear, nor does heat randomly do work. The more we understand information, the more we understand that it is impossible for genetic information to come into being without an organizing force, and, as we know, information, like heat, moves to equilibrium (entropy.) Does that help?
And, to state again..."microevolution," which, in this sentence, means variation due to any number of processes that affect gene frequency and the function of existing genes (reductive mutation) can't turn into macroevolution, which, in this sentence, is referring to speciation and the like, because speciation requires new genetic information (ie, if an organism doesnt have the genetic information to grow arms, it cannot just add the information out of thin air, though any process, to suddenly grow arms. That requires information from noise, aka heat moving against the laws of thermodynamics, ie, against entropy.)
Originally posted by Austin9599945
Isnt bacterial mutations a positive thing? They become far more resistent to drugs and then reproduce..continuing the resisitence.
Originally posted by SilverSmith
When was bacteria anything but bacteria? Bacteria can become resistant to something but does this then indicate it has mutated into another species or it is still bacteria? It would be something if that bacteria evolved into a more complex thingy, eh?
Originally posted by AshleyD
Couldn't a mutation simply be an "adaption." Does this mutation actually mean an organism has become "superior" or that it simply adapted?
Example: Nordics in the north stereotypically have pale skin, light hair, and light eyes. Africans living around the equator stereotypically have dark sin, dark hair, and dark eyes. They both are adapted to their climates. But we cannot say one "adapted race" is "superior" because that would sound racist. They are both humans who simply adapted to their environment.
Originally posted by weedwhacker
Hello all, again, may I jump in?
Originally posted by AshleyD
Not sure if everyone got what I was trying to imply. And that is, does the adaptations actually make one "superior" or simply "suited" for their environment? We can't say black people are superior or white people are superior. They just became better suited to the extremes of their environment. So did this bacteria actually become "superior" or did it "adapt?" That's all I was trying to say.
Welcome, doctorex
Yes, we've heard that joke before. The better punchline is the god saying to the man 'Get your own dirt.'
See, that's much funnier!
But, jokes aside, this is serious business...and I challenge you to show us where anything says the Universe was created out of dirt...really, please!
You see, just saying 'GOD DID IT!' is a cop-out. Too easy.
I am not proseletyzing here, I do not purport to know all of the anwers, but wouldn't it be better for a god, if there was one, to have put everything in place billions of years ago, set it into motion, and then sit back and watch it all play out? Isn't it more incredible to discover that we CAN discover? Are we not to use our brains for discovery? Or, do we have a tremondously incredible brain, capable of great things, just to blindly follow a shephard, as if we were sheep?
I think not
With an open mind, one can realize the incredible scope of the Universe. It is not just a vast playground for humans. To think that it is, is self-limiting, in my view.