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The Corvallis herd includes a group of rams that scientists delicately refer to as "male-oriented." These animals consistently ignore females and bestow all their amorous attentions on members of their own sex.
Researcher Charles Roselli says a decade of study suggests sexual orientation is largely hard-wired into the sheep's brains before birth. Now, he's trying to figure out how that happens, zeroing in on genes and hormones. In a bold test of his ideas, he hopes to engineer the birth of gay rams by altering conditions in the womb.
Sheep aren't people, but the Oregon work adds to a growing body of research that bolsters biological explanations for sexual orientation across species — including humans.
But rats, hamsters, ferrets and other lab animals flip-flop their sexual behavior when scientists manipulate the hormones they're exposed to before birth. Such experiments would be unethical in people, but some rare medical conditions offer human parallels.
A high proportion of girls with a disorder that causes them to secrete male hormones before birth grow up to be lesbian. About 40 case studies have shown boys who are surgically altered and raised as girls because of genital deformities are overwhelmingly attracted to females once they reach puberty — indicating sexual orientation is determined very early in life and is difficult to alter.
Twin studies provide evidence that homosexuality runs in the family
When Vince Healy finally came out as gay, his disapproving Catholic family was familiar with the story. His older brother had been living with a man for several years. It didn't make things any easier, the 45-year-old Ballard man recalled.
"I was very unhappy at the prospect of being gay," he said. "I kept thinking: I must be a late bloomer."
As the youngest of three brothers, one of whom is straight, Healy illustrates the two most robust findings in the science of homosexuality: It runs in families, and the number of older brothers a man has can increase his chances of being gay.
About 3 percent of American men and 1.5 percent of women describe themselves as gay or bisexual, according to the National Institutes of Health. Those percentages are three to five times higher among people who have a gay brother or sister.
But genes clearly are not the only factor, or identical twins would always share the same sexual orientation.
"That means there's a significant environmental contribution," said Sanders, who is leading a five-year, $2.5 million project for the National Institutes of Health to try to identify the genes involved.
Earlier research has pointed to several possible gene regions, but those studies were small and not definitive. With DNA from 1,000 pairs of gay brothers, Sanders' project will be much more powerful.
It's very unlikely to uncover a single "gay" gene, he said. As in most complex traits, multiple genes and environmental factors probably work together.
But when he looked into scattered reports that many gay men have older brothers, he was astounded. The findings now have been confirmed by more than a dozen studies, including several of his own: Every older brother a man has increases his chances of being gay. A man with four older brothers is three times more likely to be gay than a man with none. Blanchard estimates one out of every seven gay men owes his orientation to this "fraternal birth order" effect.
It's possible to argue for social explanations — bullying by big brothers, indulgent mothers. But Blanchard believes it's biology. Gay males with older brothers weigh less at birth than heterosexual males with older brothers, hinting that something different is happening to them in the womb.
The social and political implications of the research are impossible to ignore, leading to unease on both sides of the gay-rights debate. If science proves homosexuality is innate, is there any basis to deny gays equal treatment — including the right to marry? But if scientists unravel the roots of sexual orientation, will it some day be possible to "fix" people who don't fit the norms or abort fetuses likely to be born gay?
Much of the cutting-edge research is being conducted in other countries, because the political pressure cooker in the United States makes it difficult for scientists to get money, said Brian Mustanski, who juggles studies of the genetics of homosexuality with his main work on HIV prevention at the University of Illinois, Chicago.
But controversy can't obscure the facts, he said.
"It's pretty definitive that biological factors play a role in determining a person's sexual orientation."
Originally posted by Jakko
seattletimes.nwsource.com...
quote: But genes clearly are not the only factor, or identical twins would always share the same sexual orientation. "That means there's a significant environmental contribution," said Sanders, who is leading a five-year, $2.5 million project for the National Institutes of Health to try to identify the genes involved.
Originally posted by forestlady
Jakko, good topic. Don't think I'd use this quote, though. I mean Sanders immediately jumps to the conclusion that there is an environmental factor, without giving an explanation why.
But genes clearly are not the only factor, or identical twins would always share the same sexual orientation.
"That means there's a significant environmental contribution," said Sanders, who is leading a five-year, $2.5 million project for the National Institutes of Health to try to identify the genes involved.
seattletimes.nwsource.com
Originally posted by junglelord
being gay is I believe formed in utero.
The sexual center of the brain is different, wrong size
sexes have different size centers (dooh!)
so they have the wrong size for their sex
its therefore not their fault when people like to play a God hates you came....and no God does not hate you.
thats BS too
Originally posted by forestlady
WHY must there be environmental factors?
Originally posted by GradyPhilpott
Originally posted by forestlady
WHY must there be environmental factors?
If it's not genetic then what is left?
[edit on 2007/5/17 by GradyPhilpott]
Originally posted by forestlady
What is left are alot of other causes. There are far more factors than just genetic and environmental that determine who and what we are.
Originally posted by GradyPhilpott
Originally posted by forestlady
What is left are alot of other causes. There are far more factors than just genetic and environmental that determine who and what we are.
Please tell us what those might be.
Originally posted by 64738
Maybe is something with hormones because most of the sexual drive develops in puberty. Could also be effect of food we eat. Many possibilities... I guess gays would like to hear it's something we are born with while others will say it's learned and treat it as an error.
Well, i see gays are really attracted and in love with each other so there is something natural in it after all.