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Originally posted by mattison0992
Lots of things in biology are wrong... we discover this everyday.
Really, humor me name one. Considering the enormously broad range of disciplines within biology find one thing that has been found as absolutely wrong after passing a peer reviewed study.
John Ioannidis, an epidemiologist at the University of Ioannina School of Medicine in Greece, says that small sample sizes, poor study design, researcher bias, and selective reporting and other problems combine to make most research findings false.
Falsification is very difficult. No one can simply publish a paper or book and make it part of an existing theory. All ideas go through a rigorous peer review process before any merit can be given to new concepts. It is then opened to the whole world for comment before there is any acceptance in any field of science. There are hundreds of thousands of independent studies and peer reviews globally that would win a noble prize to prove any validated theory wrong.
The ToE is made of correct disciplines and theories of biology. Many of those disciplines and theories are also used in medicine. If an error is made within any one of those disciplines it does not go up the ladder to disrupt the discipline itself and certainly not up to any grouping of those disciplines like ToE or Medicine
But this is not the point I am making. We know what “certain aspects” of the biological theories are correct (an be it known that this comprises an enormous number theories within an enormous number of biological disciplines) and our repeated successful use of many of them in medicine re-enforces that.
The ToE uses the majority of those exact same “certain aspects” of the same biological theories, which are correct and repeatedly used in medicine. The majority of ToE is made of those very same “certain aspects”.
So, to say the ToE is wrong would be like saying that all the “certain aspects” that it is made of are wrong. But those “certain aspects” are also used in medicine.
To your point if any one of the “certain aspects” is wrong that does not make any of the other “certain aspects” wrong that is why the overall theory is not affected. But if the overall theory is wrong then, it is because the majority of it’s sub theories were wrong.
Originally posted by mattison0992
This isn't my area of expertise, and quite frankly, I couldn't care less about questions such as this. It's pseudotheological.
Interesting really, you already addressed this subject; this is part of the faith healer topic to which you added Christian Scientists. This was a response to the original reference to the Greek god Asclepius. Part of modern medicines universal symbol for emergency treatment. Also, there is a connection to the Hippocratic oath a multi-theistic oath. Modern medicine really gives credit to the most abundant surviving source of medical information, Greek biological documentation. There is irony in the “Star of Life”.
Originally posted by mattison0992
“I can't respond to this either.”
An Oxymoron
You felt compelled to quote my post and respond to it with “I can't respond to this either.”
An Oxymoron
You felt compelled to quote my post and respond to it with “I can't respond to this either.”
Originally posted by mattison0992
Ummm... me too. Soooo.....
Blind faith overshadows simple understanding.:p
Originally posted by mattison0992The antibiotic resources we have available are not as prolific as you have indicated.
Originally posted by mattison0992A common misconception and popular argument that is not correct. Antibiotic resistance has always existed. It existed prior to the 'invention' of antibiotics. You can't have antibiotics without resistance genes. As long as there have been antibiotics there have been resistance genes. Proliferation of antibiotic resistance is nothing more than reshuffling of pre-existing genetic material. It doesn't 'evolve.'
wikipedia
When evolution is used to describe a fact, it refers to the observations that populations of one species of organism do, over time, change into new species. In this sense, evolution occurs whenever a new species of bacterium evolves that is resistant to antibiotics which had been lethal to prior strains. en.wikipedia.org...
www.talkorigins.org... evolution is simply "a process that results in heritable changes in a population spread over many generations"
cdc.gov Resistance to quinolones occurs through chromosomal mutations in the genes
Originally posted by mattison0992You can't have antibiotics without resistance genes. As long as there have been antibiotics there have been resistance genes.
Originally posted by mattison0992It doesn't 'evolve.'
Originally posted by mattison0992
Exactly, but it has nothing to do with either evolution or ToE.
Originally posted by mattison0992
originally posted by Gravityisatheory
It also indicates that you missed understood the quote you used.
This is an incorrect use of the term ToE. Theories do not directly contribute anything they make predictions as it says in the quote.
Then this is news to the evolutionary biologists who use ToE to make predictions about the world. Perhaps you followed the saga of one of the most recent transitional fossils to be found. Evolutionary Biologists PREDICTED they would find such a fossil in such a location based on a multidisciplinary analysis of ToE. IOW, they used ToE to PREDICT they would find such a fossil in such a location.
originally posted by GravityisatheoryBut to address the intent
Describe three (3) things the evolution has contributed to medicine?
1) Genomics, en.wikipedia.org...
Originally posted by mattison0992 Genomics arose out of the field of biochemistry and subsequently spawned the field of molecular biology. It didn't arise out of evolutionary theory.
Originally posted by mattison0992 It didn't arise out of evolutionary theory
Originally posted by mattison0992 They are not a product of ToE.
Originally posted by mattison0992 ToE doesn't 'predict' these things.
Originally posted by mattison0992]IOW, they used ToE to PREDICT”.
Originally posted by mattison0992 How does this assist the medical field? It doesn't.
Originally posted by mattison0992 This is molecular biology. This has nothing to do with ToE. Chromosomal translocations and other abnormalities saying nothing of ToE. ToE didn't discover these, biochemists did. ToE doesn't 'predict' these things.
Originally posted by mattison0992
This is just penny ante semantics and changes nothing.
originally posted by mattison0992
Lots of things in biology are wrong... we discover this everyday.
originally posted by Gravityisatheory
Really, humor me name one. Considering the enormously broad range of disciplines within biology find one thing that has been found as absolutely wrong after passing a peer reviewed study.
A list like this could get long very quickly.
Perhaps you didn't see this article that came out last year.
External Source
John Ioannidis, an epidemiologist at the University of Ioannina School of Medicine in Greece, says that small sample sizes, poor study design, researcher bias, and selective reporting and other problems combine to make most research findings false.
If you really want an extensive list, we can do that too.
Originally posted by mattison0992
You obviously don't understand the process of peer review. Often times this 'rigorous' process amounts to review by one or two other scientists who have a whole stack of stuff they're reviewing in addition to their own research. Most scientists don't operate on the 'theory' level, and aren't out to prove things wrong. For the most part they are locked into their own specific sub-category of their sub-discipline, and don't really think about the big picture. Rocking the boat is no way to ensure future funding or future publication. In fact, history has demonstrated that articles that are true but go against popular theories are disproportionately rejected.
Originally posted by mattison0992
Originally posted by Gravityisatheory 4) How about a whole site of contributions. evolution.berkeley.edu...
Actually this site doesn't deal with 'evolutionary contributions to medicine,' it deals with 'evolutionary concerns' within medicine, that is drug resistance in pathogens etc, as well as the genetic basis for a couple of diseases. If evolutions big contribution to medicine is that 'microbes evolve resistance,' then that's not much of a contribution. How does this assist the medical field? It doesn't.
Originally posted by mattison0992
Actually this site doesn't deal with 'evolutionary contributions to medicine,' it deals with 'evolutionary concerns' within medicine,
Originally posted by mattison0992
If evolutions big contribution to medicine is that 'microbes evolve resistance,'
originally posted by Gravityisatheory6) Even drugs; Digitalis, morphine, quinine, and ephedrine are all modern medicines that have been passed down to us from prehistoric signature practice.
Originally posted by mattison0992
Okay, but this has NOTHING to do with ToE.
originally posted by Gravityisatheory
· The understanding of cellular variation
· www.talkorigins.org...
Originally posted by mattison0992 None of this is in dispute.
Originally posted by mattison0992 None of this is in dispute.
Originally posted by mattison0992 Medicine deals with observable measurable, confirmable concepts, while ToE deals in speculation and inference. The two are not even remotely comparable.
originally posted by Gravityisatheory
But this is not the point I am making. We know what “certain aspects” of the biological theories are correct (an be it known that this comprises an enormous number theories within an enormous number of biological disciplines) and our repeated successful use of many of them in medicine re-enforces that.
Originally posted by mattison0992 Nothing done in medicine 'reinforces ToE.' It doesn't happen.
Originally posted by mattison0992 “ToE can't be proven by it's very nature.”
Originally posted by mattison0992 Medicine deals with observable measurable, confirmable concepts, while ToE deals in speculation and inference. The two are not even remotely comparable.
Originally posted by mattison0992 “ If rabbit fossils were found in Pre-Cambrian rock tomorrow, it would be devastating for ToE and the theory of common descent. However, it wouldn’t make other fossils 'wrong,' they still are what they are, it would just make the interpretation of the evidence wrong. If evolution is wrong, a number of inferences are wrong, …. the only thing that loses is evolutionary biology.”
In fact, history has demonstrated that articles that are true but go against popular theories are disproportionately rejected.
Originally posted by mattison0992
1. This isn't my area of expertise.
2. I couldn't care less.
Originally posted by Gravityisatheory
Originally posted by Gravityisatheory
I did not say that they were currently 'available'. Since 'available' only applies to FDA approved antibiotics, yes you are correct there are not many today.
While this is true in general, this isn't the case with antibiotics. Successful antibiotics are tough to come by, and there really aren't that many new ones in the pipeline. The new one's are generally variations on existing structures, which mean resistance comes quickly.
But the bottom line hold up is money. The legal, chronological and financial layout in developing and bringing a completely new pharmaceutical product to the market is prohibitive for large corporations.
In reality there have not been many antibiotics going up to the FDA for approval (for human use) but that does not exemplify what research is going on.
Please provide a reference and
Please let the following three sources know of their errors.
The first point to make is that resistance genes and mechanisms existed long before antibiotics were used. For example, antibiotic resistant bacteria have been isolated from deep within glaciers in Canada s high Arctic regions, estimated at 2000 years old.9 The micro-organisms used to produce antibiotics must, by definition, be resistant and are thus a source of antibiotic resistance genes.
Your reply is Straw Man Logic
Describing a mechanism of evolution does not disprove it. Go-ahead reshuffle pre-existing genetic material that is part of evolution.
Is it your position that bacterial evolution doesn t happen or do you just not like adhering to the current definition shown above?
You want to explain what/why/how pre-existing genetic material gave bacteria the need to have the ability to breakdown Nylon?
Actually there is no conflict at all. I never said antibiotics and resistance genes are equally prolific. I said as long as there have been antibiotics there have been resistance genes. Please refer to the italicized text in the previous ref.
This implies a conflict with your previous comment about the proliferation antibiotic resources. Now you are claiming (without references) that antibiotics basically are as prolific as the bacteria with resistant genes. Which is almost endless. I m sure numerous studies of Precambrian bacteria will help trace it all back to a common ancestor as you appear to support in some weird way.
Now you are giving me support to say that the antibiotics are as plentiful as the bacteria they fight
octavia.zoology.washington.edu...
Sure the observable evolution of bacteria may have been predominantly by horizontal gene movement but this does not alter the basis by which 'evolution' was determined, basic heritable changes. Recombination still does occur and in exclusive populations the gene path is not always reproducible as the exclusive mutations cause permanent changes relating the environmental influences to that particular population. When and if the populations ever mix again they may not be able to reestablish historic traits to sustain a viable population against a repeat enemy or each other. Yes one population may even borrow the resistance from another. This is part of natural selection. Whether or not it comes around again is also irrelevant.
Your reply is Straw Man Logic
There was no intent to show that, because you asked what it said about our biological knowledge and what narcotizing faceitis said about our biological knowledge. You did not ask what either had to do with evolution or ToE.
Necrotizing Faceitis is a factor in Natural Selection.
originally posted by Gravityisatheory
It also indicates that you missed understood the quote you used.
More Straw Man Logic
You didn t comprehend the quote not just once but twice. Or is this just ignorance?
That s what I said, specifically I said that the ToE Theories .make predictions !!
Which one of the words in my quote threw you off?
Originally posted by mattison0992 Genomics arose out of the field of biochemistry and subsequently spawned the field of molecular biology. It didn't arise out of evolutionary theory.
More Straw Man Logic
Where in my quote did I say 'evolutionary theory'?
I didn't I said evolution.
More Straw Man Logic
No kidding. I never suggest that it did. You would understand more if you would learn the vocabulary. The field of biochemistry supports the ToE. The reverse is not true, how astute. The field of biochemistry supports medicine. Medicine pays for the biochemistry.
Describe three (3) things the evolution has contributed to medicine?
Biochemistry used for numerous purposes including medical purposes that validates the biochemistry by replication, by successful application.
It is the last step in verifying the tools, method, theories and concepts are right, replication. When using biochemistry to examine prehistoric life, the ToE can be used to make predictions. One part of ToE that is used is simply 'evolution . If you can t use biochemistry in today s world then there is no way you could understand and interpret the results of biochemistry used to study pre-historic life. Therefore biochemistry supports ToE, very simple.
This is absolutely NOT what you said, as I've indicated above.
More Straw Man Logic
You are refuting claims involving evolution by saying that they did not arise out of ToE. That Is Correct they did not.
If there were no evolution demonstrated in the genes then we wouldn t have a need for Genomics in the first place because there would be no reason to study genes.
Are you kidding? All correct (not falsified or made up) medical biological knowledge is beneficial. It reduces the number of unknowns that need to be questioned and/or solved.
More Straw Man Logic
I didn't say the ToE discovered anything. The ToE didn t discover, it is used to predict.
Why do you know about Chromosomal Translocations and abnormalities?
Why should anyone care? Don't you think there's a benefit to studying these things?
Are there not heritable things being passed to the next generation? That is called evolution.
"Nothing in Biology Makes Sense Except in the Light of Evolution" Theodosius Dobzhansky
This quote has been out there quite a while and I don t see anyone stepping up to say it s wrong. Except you!
To me (and I know you are going to hammer me on this) this means that biology supports Evolution. Since Evolution is a huge portion of the Theory of Evolution, Biology also supports The Theory of Evolution. Seams very simple.
Extensive list? What list are you talking about? You have gotten one thing.
You haven't satisfied the request. It was to find one thing in biology that was first shown right by the scientific method (including peer review) and then later showing it wrong.
Welcome to press releases and publishing perks, that s the game. You have to start somewhere and get the information out for review.
That's why we have the peer review process. The science world knows that the actual publishing is to be 'taken with a grain of salt'.
To weed out the bad research and bogus studies, they are scrutinized and reviewed and examined. From that same article; "We should accept that most research findings will be refuted. Some will be replicated and validated. The replication process is more important than the first discovery,"
No, I don t understand your shortsighted comprehension of it. Nor do I understand your intension of giving a false impression of it.
It is primarily performed by the publisher (which can be a department of people).
often times is a very misleading term within the context you use it.
Part of what makes it a rigorous process is because of the availability of qualified reviewers. Since they have a professional involvement with the subject they are very concerned how publication will affect their field of study. Perhaps you should read the rest of the article you sighted.
Additionally it is anonymous, it doesn t come back to you, sure you may know what company or department the work has gone but you really don t know who the reviewers are or how many.
Instead of supporting bogus claims about daily errors in biology, the topic has been switched to something you claim to know about, peer review. Apparently your understanding of it (in addition to your reference from the University of Ioannina School of Medicine in Greece ) is how to participate in false studies, get them published with false data and obtain misguided funding. Is this something you know by first hand experience?
I can t imagine how anyone with even the slightest amount of logic could consider a peer-reviewed publication as proof of anything. The purpose of peer-reviews is to remove crackpots and obvious frauds. It does just that. It may not be perfect but neither is weather reporting and we aren t getting rid of that.
The reason I mentioned peer review was twofold. One, looking at the substance of your comments there is a question of your qualification for discussing any physical science. Most people understand that peer-review is only a very small portion of the big picture in order for anything to become 'accepted' as part of 'biology' or any physical science. The scientific method is the big picture.
But, now I know the whole scientific method is new to you.
Secondly, I was hoping to encourage you to provide a solid reference for your exaggerated claims. I asked you to find something in 'biology'
you instead found an article that basically says that people lie for different reasons.
Your reference fails to shown any part of biology wrong.
Evolutionary concerns within medicine? That means that evolution is important to medicine. What s your point? That site is referenced by the talkorigins page, you know the one where you said none of it was in dispute.
In response to:
4) How about a whole site of contributions.
Describe three things that ToE has contributed to medicine.
So the alternate basis of your logic is, since you don t understand it, it must be false. There are an enormous amount of medical evolutionary studies because they are so intertwined. The field(s) is still very young.
You really are oblivious to the obvious.
Actually you don't appear to understand it.
What does the university of Berkeley know anyway? The nerve of them putting up a page titled;
Relevance of evolution: medicine
by the Understanding Evolution team
Who care that studying the historical path of mutation to a gene called CCR5 will lead to a cure for HIV? That s not a contribution to medicine right?
Originally posted by mattison0992
If evolutions big contribution to medicine is that 'microbes evolve resistance,'
You said, "They don't evolve", you need to make up your mind.
NATURAL SELECTION!!
It is absolutely part of ToE. It has nothing to do with direct biological evolution. It is part of natural selection. Much more complicated when talking about humans. What group do you think has a better chance of offspring survival? The ones with medical knowledge and abilities or the ones without it? If faith healers refuses to give simple medical treatment to their offspring the chances of their genes continuing through to the next few generations is significantly reduced. That is natural selection at work.
Originally posted by mattison0992 None of this is in dispute.
Obviously you either didn t read it or don t understand any of it!!
I ve been reiterating this information repetitively only to you have you refute it. You appear to be resistive to all it says. IE not open minded IE not capable of being objective IE stuck on blind faith.
From TalkOrigins The ToE It unites all the fields of biology under one theoretical umbrella.
This means that biology supports ToE. All fields of biology. Including medical fields of biology. Thus Medicine as part of biology falls under that umbrella. Medicine supports ToE, very simple.
From TalkOrigins the Fact of Evolution Evolution is the cornerstone of modern biology
I guess it is a huge leap of faith to believe that modern biology is also the cornerstone of modern Medicine. Right?
Now it is clear what the problem is. You have absolutely no idea what a theory is. This is way over your head. That explains why all of your replies miss the point entirely. You need to abandon your layman s definition of a theory because it is absolutely wrong under the context of any physical science. You should drop your guise as a scientist, no competent scientist in any empirical science would use this definition.
From TalkOrigins It unites all the fields of biology under one theoretical umbrella.
Reproductive success (fitness) has two components; direct fitness and indirect fitness. Direct fitness is a measure of how many alleles, on average, a genotype contributes to the subsequent generation's gene pool by reproducing. Indirect fitness is a measure of how many alleles identical to its own it helps to enter the gene pool. Direct fitness plus indirect fitness is inclusive fitness. J. B. S. Haldane once remarked he would gladly drown, if by doing so he saved two siblings or eight cousins. Each of his siblings would share one half his alleles; his cousins, one eighth. They could potentially add as many of his alleles to the gene pool as he could.
You don t think that modern medicine has any effect on reproductive success?
Or that human intervention has affected Natural Selection from extinctions to captivity, slavery and breeding. Artificial Selection is part of Natural Selection.
Natural Selection deals with improving the success of offspring. Hospitals do that.
They use biology of which (as you say is not in dispute from talkorigins) evolution is the cornerstone. Therefore they are part of the whole picture of 'fitness .
More Straw Man Logic
That is very nice. How is that applicable to what you quoted?
Originally posted by mattison0992 ToE can't be proven by it's very nature.
More Straw Man Logic
No kidding, I never said otherwise. If proven it would be fact not theory.
ToE is NOT used in medicine.
Not directly. Biological theories are used in medicine. The ToE includes those theories.
Like the hypothesis that a historical resistant gene has given 20% of Europe resistivity to HIV.
Seams to me that if the ToE has explanatory power in biology it also has it in medicine.
Originally posted by mattison0992 If rabbit fossils were found in Pre-Cambrian rock tomorrow, it would be devastating for ToE and the theory of common descent. However, it wouldn t make other fossils 'wrong,' they still are what they are, it would just make the interpretation of the evidence wrong. If evolution is wrong, a number of inferences are wrong, . the only thing that loses is evolutionary biology.
NO. You have no idea what evolutionary biology is!
Absolutely not, and for some of the reasons you have sited.
that small sample sizes, poor study design, researcher bias, and selective reporting and other problems combine to make most research findings false.
First it would have absolutely nothing to do with the fact of evolution, this would be dealing with the Theory of Evolution.
Secondly theories are out there to be modified that does not make them entirely wrong.
Third, you would need to prove it was part of the same biological 'tree , otherwise it would not affect the theory of common descent what so ever.
There is no reason to believe it all started from a singular event.
Forth, even if you could say this was proof of spontaneous generation and orthogenesis, it would not in any way harm the ToE, it would become part of it.
You can t possibly bring down ToE.
Suppose you could prove from this rabbit fossil (aside from the unexplained age and location), suppose you could show that is was nothing other than a digestive track for any bacteria possible and a whole bunch of stem cells with blank DNA.
That would certainly affect the course of future biology. It would trim but it would not bring down ToE, that s the nature of the theory.
I don t care if you find a fountain pen in a Precambrian rock. It would not amount to a drop of water in the ocean.
It would be just like finishing a huge one of a kind billion-piece puzzle of the New York City skyline and finding one additional puzzle piece that is obviously part of Mickey Mouse s nose. What effect would that additional piece have on the rest of the puzzle? None.
One in a billion. That piece is obviously part of a different puzzle.
Right. After demonstrating it, confessing your ignorance is appropriate.
Your blind faith has made you so closed minded and biased that you can t see the forest through the trees.
Originally posted by melatonin
I think ToE and common descent does have an input into medical knowledge. We use animals as models for the behaviour of pharmaceuticals in humans. Given they are not always perfect, but why do we use mammals rather than insects, fish, or birds?
I personally know of a researcher who uses marms in their research. They'll create a lesion and assess how this neural lesion affects behaviour.
This data is used for neurological therapies amongst other things. Recently, Colin Blakemore, a top neuroscientist in the UK and head of the medical research council, suggested that at some point we may need to use our closest relatives, apes, in medical research. Why?
The usefulness of a laboratory animal model should be judged on how well it answers the specific questions it is being used to answer, rather than on how well it mimics the human disease.
Conditioning theories all stem from a knowledge that behaviour only differs by degree across species, ask Jospeh LeDoux how much his studies on fear conditioning in rats have helped us understand anxiety disorders such as PTSD. Pavlov, Skinner, and Watson decided that dogs, rats, and pigeons were good models for conditioning experiments, and I guess they accepted the similarities between human and animal behaviour/physiology to justify this. Behavioural therapies are dependent on these studies.
There is a wad of neuroscientific research on our relatives that will provide medical benefits for humans.
And a friend told me that a study on fruit-fly casings actually provided an understanding of colon cancer (I know nothing about its validity as an example though, haha).
why do we use mammals rather than insects, fish, or birds?
I suppose the obligatory creationist answer is "common design"...
But I think the important point is to actually ask - what has creationist/ID science ever done for our lives? Not just medicine, but in all aspects of improving our lives...
Originally posted by melatonin
Mein gott, the one good example we can use to show that ToE is falsifiable and we have an evolutionist denying its validity...
Originally posted by mattison0922
Because their systems are more closely similar of course. Obviously mammalian systems are closer to other mammalian systems than they are to bird systems, but WHY they are closely similar is NOT a fact.
Forgive me, but what in the heck is a marm?
Obviously because their systems are more closely similar. However certainly animal models, as your above post indicates, are often chosen for their tendency to exhibit a disorder that coincides with some human disease.
Certainly primates are more closely related to humans than are beagles.
Of course this isn't the case, most human diseases have a 'pet' research animal that 'models' a particular facet of disease. There are HIV mice, alzheimers mice, transgenic pigs for alzheimers, etc. There is really no consensus on which organisms are the best models for human disease. In fact, accoding to This site
The usefulness of a laboratory animal model should be judged on how well it answers the specific questions it is being used to answer, rather than on how well it mimics the human disease.
So it would appear that animal models don't even have to mimic human disease, merely provide an answer to a single aspect about the disease. In fact that same site has a list of general rules for selection of animal models... notably absent from this list is the 'evolutionary relatedness' of the model.
I don't deny the contribution that animal research has made to science. Rats, dogs, pigeons... what's the commonality there. Pigeons aren't closely related to humans at all, and they are yet a good model. IMO, this actually stands in direct opposition to what ToE would predict.
There is a wad of neuroscientific research on our relatives that will provide medical benefits for humans.
The word 'relatives' is merely an inference, not a fact.
And a friend told me that a study on fruit-fly casings actually provided an understanding of colon cancer (I know nothing about its validity as an example though, haha).
This stands in complete opposition to the first paragraph in your post where you stated:
why do we use mammals rather than insects, fish, or birds?
In fact, this stands in opposition to the pigeon example provided above also.
I suppose the obligatory creationist answer is "common design"...
Which in reality, is no more or less verifiable than is common ancestry.
This isn't a scientific question... at least the 'all aspects of improving lives' portion. ToE hasn't contributed to medicine, and neither has CS or ID.
www.psychomedia.it...
Beyond a Joke: From Animal Laughter to Human Joy?
In the beginning was the word… but was the word funny? Research suggests that the capacity for human laughter preceded the capacity for speech during evolution of the brain. Indeed, neural circuits for laughter exist in very ancient regions of the brain (1), and ancestral forms of play and laughter existed in other animals eons before we humans came along with our hahahas and verbal repartee. Recent studies in rats, dogs, and chimps (2, 3) are providing evidence that laughter and joy may not be uniquely human traits.
The capacity to laugh emerges early in child development, and perhaps in mammalian brain-mind evolution as well. Indeed, young children, whose semantic sense of humor is marginal, laugh and shriek abundantly in the midst of their other rough-and-tumble activities. If one looks carefully, laughter is especially evident during chasing, with the chasee typically laughing more than the chaser. As every aspiring comedian knows, success is only achieved if receivers exhibit more laughter than transmitters. The same behavior patterns are evident in the “play panting” of young chimps as they mischievously chase, mouth, and tickle each other (2).
Laughter seems to hark back to the ancestral emotional recesses of our animalian past (3, 4). We know that many other mammals exhibit play sounds, including tickle-induced panting, which resembles human laughter (2, 4, 5), even though these utterances are not as loud and persistent as our sonographically complex human chuckles (6). However, it is the discovery of “laughing rats” that could offer a workable model with which to systemically analyze the neurobiological antecedents of human joy (3). When rats play, their rambunctious shenanigans are accompanied by a cacophony of 50-kHz chirps that reflect positive emotional feelings (7). Sonographic analysis suggests that some chirps, like human laughs, are more joyous than others.
Could sounds emitted by animals during play be an ancestral form of human laughter? We have shown that if rats are tickled in a playful way, they readily emit these 50-kHz chirps (3, 8). The rats we tickled became socially bonded to us and were rapidly conditioned to seek tickles. They preferred spending time with other animals that chirped a lot rather than with those that did not (3). Indeed, chirping in rats could be provoked by neurochemically “tickling” dopamine reward circuits in the brain (9), which also light up during human mirth (10). Perhaps laughter will provide a new measure for analyzing natural reward/desire circuits in the brain, which are also activated during drug craving (7, 11).
Deciphering the neural circuitry of playful chirping in rats is an important goal of future research. Such knowledge may help to reveal how joking and horsing around emerged in our expansive higher brain regions. Although no one has investigated the possibility of rat humor, if it exists, it is likely to be heavily laced with slapstick. Even if adult rodents have no well-developed cognitive sense of humor, young rats have a marvelous sense of fun. We have already bred rats that exhibit excess playful chirping (12), and thereby hope to track down some of the genes for joy. Perhaps we will even stumble on new molecules to alleviate depression as well as some excessive exuberance disorders (13, 14).
Research on rough-housing play in mammals, both sapient and otherwise, clearly indicates that the sources of play and laughter in the brain are instinctual and subcortical (1, 3, 8). Although our species-typical capacities for verbal joking surely reflect highly ref ined cortico-cognitive skills (15), those incoming words must somehow tickle the ancient playful circuits of our minds for joy to occur. As we learn “to rib” each other with words, as opposed to just rough-and-tumble horse-play, we may be developing new synaptic connections to joyous neural zones that reside far below our cerebral crowns. It has long been intimated that laughter has many health benefits as well (16)
Human laughter, however, has a dark and dominant side. According to the philosopher Thomas Hobbes, “Laughter is nothing else but a sudden glory arising from some sudden conception of some eminency in ourselves.” Experts compiling the DSMV psychiatric guidelines may wish to consider how excessive gloating laughter contributes to “eminent-domain” disorders worthy of more precise psychiatric diagnosis. New treatments for such disorders might include strengthening the capacity for internal silent laughter (17), one of the few remaining mental capacities that may be uniquely human.
Many still believe that emotional feelings, from joy to grief, are special capacities of the human brain, but as Darwin taught, it just ain’t so (18). The recognition of emotional feelings in our fellow animals should no longer be reflexively deemed an anthropomorphic sin (4, 8). Perhaps it is time for neuroscience to accept that animals are capable of many emotional feelings (8, 19) (despite the consternation that may cause for investigators who treasure the study of fear behaviors more than joy).
We find ourselves at the tall-tale end of an intellectual era when the animal mind was deemed nonexistent or impenetrable. Gentle Darwin was prescient when he coaxed us to see our own emotional nature as continuous with that of our fellow animals (18). By studying the many emotional “instinctual” behaviors and related learning capacities of other animals, we may develop excellent ways to fathom the neuroemotional foundations of human consciousness. Weighty data are tipping the scales of evidence in favor of ever more subtle affective conceptions of animal minds, Homo sapiens included (8). Although our emotional systems are neither uniquely nor intelligently designed, it is a blessing that we can finally understand their affective nature (19). As William Blake incomparably declared in Auguries of Innocence (1863): It is right it should be so; Man was made for joy and woe; And, when this we rightly know Through the world we safely go. Joy and woe are woven fine A clothing for the soul divine; Under every grief and pine Runs a joy with silken twine.
If the mental lives of other animals are also created from the neural threads of joy and woe (not to mention many other feelings), we may need to openly consider the nature of their affective brains in order to understand our own. This brings special responsibilities for the scientifically sapient savants among us (20, 21). Although some still regard laughter as a uniquely human trait, honed in the Pleistocene, the joke’s on them.
Proof of evolution? What? Why would you conclude that I was trying to “prove” evolution. ToE is a theory, something that is not proven but supported by proof. There is a difference.
A scientific theory is a well-substantiated explanation of some aspect of the natural world, based on a body of facts that have been repeatedly confirmed through observation and experiment. Such fact-supported theories are not "guesses" but reliable accounts of the real world.
Originally posted by mattison0992 A common misconception and popular argument that is not correct. Antibiotic resistance has always existed. It existed prior to the 'invention' of antibiotics. You can't have antibiotics without resistance genes. As long as there have been antibiotics there have been resistance genes. Proliferation of antibiotic resistance is nothing more than reshuffling of pre-existing genetic material. It doesn't 'evolve.'
Please provide a reference and
Please let the following three sources know of their errors.
On the other hand, it is also a fact that antibiotic resistance is observed even in bacteria isolated from totally uninhabited and thinly populated places, where they are unlikely or least likely to come in contact with the antibiotics (Chattopadhyay and Grossart, 2010).It is evident that antibiotic resistance is an outcome of evolution and pre-exposure of microorganisms to antibiotics is not a pre-requisite for emergence of resistance. In a systematic analysis, the conjugative plasmids occurring in several bacteria belonging to Enterobacteriaceae obtained from Murray collection were found to belong to the same incompatibility group as those present in contemporary Enterobacteriaceae (Datta and Hughes, 1983). It was shown that emergence and spread of conjugative plasmids, which are known to be a major vehicle for transmission of resistance, were not fostered by the widespread use of antibiotics, rather these plasmids evolved by inclusion of resistance-conferring genes in pre-existing plasmids (Datta and Hughes, 1983; Hughes and Datta, 1983).