First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns

a reply to: TheValeyard

I see so many bad things happening because of this.

a reply to: DBCowboy


Totally.
Have we not learned from the pandemic?
Like, come on, people.

a reply to: TheValeyard

You said they could make us immortal and curb over-population, well, I think it'd make more sense to simply make a lot of us sterile, and make themselves immortal. Would it not?

Yes but making the lot of us Sterile eventually ends with the Extinction of the Working class. What are the Immortal Rich going to do with the Working class gone ?

Shorter life-cycle means the person has a shorter period of time to "get wise", and thus is easier to manipulate, while they, and only they, could grow vastly more knowledgeable through their time.

For sure that is the Truth , The Lords of the Middle ages outlawed Commoners from reading and the Commoners toiling in the fields lived much shorter lives.

So make a disposable working class then ? I could see that but even still in my mind Logistically it makes more sense to have a Working class with extended life cycles.

originally posted by: asabuvsobelow

originally posted by: TheValeyard
a reply to: Another_Nut

It's just gonna create further economic stratification.
The useful gene edits will be prohibitively expensive, and will stay that way.
Multimillionaires will buy them and live forever ageless with no disease,
while Johnny at the window factory has testicular cancer and dies at 45
still on the clock because he couldn't get PTO for cancer, and he was trying to get all the hours
he could to save up for a gene edit to cure him.

It sounds like really great technology, but it's not gonna be implemented the way you think it will.

A fair point I've heard many times before and for the most part I agree.

Save one big point.

If we as a human species are ever going to Colonize other planets and Conduct interstellar Travel then we have to figure out a way to Edit the human Genome to extend life and make Humans more resilient and adaptable to space travel .

CRISPR Tech is that answer.

if we stay on earth then it will be used in another way . The Earth will be depopulated and the Powerful will create a working class with the remaining people and this working class will have extended life times so they can labor longer essentially accomplishing the labor of multiple humans over multiple life times.

Just about every '1st world' country on Earth has been 'depopulating' for decades. They don't have to do anything for it to happen.

But in an economic system that is entirely based on the fantasy of perpetual eternal growth, depopulation is a major issue. The 'powerful' are only powerful if they can be acquisitive of the wealth and output of large populations. If they depopulated the earners and the makers, they would loose power and income, because ultimately, they contribute very little themselves.

a reply to: asabuvsobelow

Not "the lot of us".
"A lot" of us.

Big difference.

Well, this is truly INSANE,l considering that cholesterol does not cause heart disease, and that all of the studies done clearly show that all cause mortality goes UP as your cholesterol levels go DOWN.

originally posted by: Another_Nut

“It’s a tremendous scientific milestone because it’s the first time that they’ve been able to show that a single base pair of DNA editing, using CRISPR technology in humans, has had a clinical effect,” says Ritu Thamman, a cardiologist at the University of Pittsburgh in Pennsylvania. “From the clinical point of view, it has the potential to open a new way of treating coronary artery disease” that could involve people receiving a ‘one and done’ treatment rather than taking daily pills.

But the findings have also drawn criticism. Two serious adverse events in the trial, including a death, have raised safety concerns, and Verve’s share price plummeted by nearly 40% following the results’ release despite their promise.

nature article

i know people have been messing with CRISPR for a while now but this i really like... and it brings us one step closer to real world gene editing on demand, something i am totally in favor of

just thought this was a nice story to see as we baby step our way into this brave new world.

more crispr news

originally posted by: marg6043
a reply to: Another_Nut
statins does not discriminate and will damage the liver.

Not only that, statins that are capable of crossing the blood-brain barrier like Lipitor (not all can) actually cause Alzheimers, almost like flipping a switch. It takes about 6 weeks to cause it once started on the drug, and 6 weeks to recover fully after you stop taking it.

Statins should be outlawed.

originally posted by: TheValeyard
a reply to: asabuvsobelow

Not "the lot of us".
"A lot" of us.

Big difference.

lol My bad

I read on a different website that China created a monkey with green glowing eyes and green glowing fingers. It had to do with embryo manipulation though.

We better pre-assembe, literally, the soon to be irl-avengers. I vote we start with him.

Isn't death a normal possible side effect included on many advertised drugs these days?

Second.

Honestly cholesterol is not bad, brains need it like others have mentioned. Biggest issue is inflammation and things that cause it like processed sugars and bad fats, which causes scarring and then the cholesterol builds up and causes issues. The body still needs that cholesterol or else it wouldn't make it.

Western Medicine seems focused on a repeat customer with symptoms treated with $$$ pharmaceuticals

I tend to look for a cause, and things that can be fixed by simple diet changes or added vitamin/supplement

originally posted by: tanstaafl

originally posted by: marg6043
a reply to: Another_Nut
statins does not discriminate and will damage the liver.

Not only that, statins that are capable of crossing the blood-brain barrier like Lipitor (not all can) actually cause Alzheimers, almost like flipping a switch. It takes about 6 weeks to cause it once started on the drug, and 6 weeks to recover fully after you stop taking it.

Statins should be outlawed.

To me, statins are a sign of a quack doctor

24

25

26

quadruple post lol

dbl post

triple post

originally posted by: ChiefD
a reply to: Another_Nut
I have high LDL cholesterol.

Too bad you don't realize that that is actually a good and healthy situation to be in.

My doctor just doubled the dose of my atorvastatin.

Be careful when upping the dose on this one, it crossed the blood-brain barrier and can cause alzheimers like symptoms...

I've tried about everything to get that number down, and nothing seems to be working.

The science that claims that high cholesterol is completely bogus, flawed science, and when the so-called studies are examined closely, the underlying data actually shows the opposite.

Please do yourself a favor, and learn the truth:

originally posted by: Aliquandro2
Honestly cholesterol is not bad, brains need it like others have mentioned. Biggest issue is inflammation and things that cause it like processed sugars and bad fats, which causes scarring and then the cholesterol builds up and causes issues. The body still needs that cholesterol or else it wouldn't make it.

Western Medicine seems focused on a repeat customer with symptoms treated with $$$ pharmaceuticals

I tend to look for a cause, and things that can be fixed by simple diet changes or added vitamin/supplement

Yeah, nope. I tried diet changes. At one point, I lost 35 pounds. My cholesterol didn't budge, not one bit. Then I tried some supplements that stated it would work at getting bad cholesterol down. Nope, didn't budge. For many, diet changes and taking supplements doesn't do jack squat.

One of the things my doctor did mention as to bad cholesterol going up was stress. Yeah, my husband of 30 years died last November. I guess I've been under some stress, LOL. Before that, the number stayed stable but shot up in the last year. I don't think that was a coincidence.

I believe that most who have high bad cholesterol need to be on statins. The only thing is, when those stop working, what then? That's where I'm at now.