First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns

“It’s a tremendous scientific milestone because it’s the first time that they’ve been able to show that a single base pair of DNA editing, using CRISPR technology in humans, has had a clinical effect,” says Ritu Thamman, a cardiologist at the University of Pittsburgh in Pennsylvania. “From the clinical point of view, it has the potential to open a new way of treating coronary artery disease” that could involve people receiving a ‘one and done’ treatment rather than taking daily pills.

But the findings have also drawn criticism. Two serious adverse events in the trial, including a death, have raised safety concerns, and Verve’s share price plummeted by nearly 40% following the results’ release despite their promise.

nature article

i know people have been messing with CRISPR for a while now but this i really like... and it brings us one step closer to real world gene editing on demand, something i am totally in favor of

just thought this was a nice story to see as we baby step our way into this brave new world.

more crispr news

a reply to: Another_Nut


It's just gonna create further economic stratification.
The useful gene edits will be prohibitively expensive, and will stay that way.
Multimillionaires will buy them and live forever ageless with no disease,
while Johnny at the window factory has testicular cancer and dies at 45
still on the clock because he couldn't get PTO for cancer, and he was trying to get all the hours
he could to save up for a gene edit to cure him.

Some high ranking or black ops soldiers will eventually be "revised" to make them more resistant to gas attacks and have faster healing and reflexes,
but the grunts probably won't cause they're not worth the expense, and the average private sector person isn't ever gonna get to benefit from this.

It sounds like really great technology, but it's not gonna be implemented the way you think it will.

originally posted by: TheValeyard
a reply to: Another_Nut


It's just gonna create further economic stratification.
The useful gene edits will be prohibitively expensive, and will stay that way.
Multimillionaires will buy them and live forever ageless with no disease,
while Johnny at the window factory has testicular cancer and dies at 45
still on the clock because he couldn't get PTO for cancer, and he was trying to get all the hours
he could to save up for a gene edit to cure him.

It sounds like really great technology, but it's not gonna be implemented the way you think it will.

A fair point I've heard many times before and for the most part I agree.

Save one big point.

If we as a human species are ever going to Colonize other planets and Conduct interstellar Travel then we have to figure out a way to Edit the human Genome to extend life and make Humans more resilient and adaptable to space travel .

CRISPR Tech is that answer.

if we stay on earth then it will be used in another way . The Earth will be depopulated and the Powerful will create a working class with the remaining people and this working class will have extended life times so they can labor longer essentially accomplishing the labor of multiple humans over multiple life times.

a reply to: asabuvsobelow

Ah, but who gets to go?


And why spend all the time and money gene editing the proles,
when you could gene edit yourself and build a new world for the super rich on another planet?


Elites prioritize monetization of commodities, do they not?
Besides, if you let everyone have it, then it's not as valuable anymore!
It's like the minimum wage argument.
Not saying I agree, but I think that's the way they'll view it.

a reply to: Another_Nut

Amazing! what a time to be alive huh?

a reply to: Another_Nut

One dead is too many, no worth it.

Is a miss conception bout cholesterol that the big pharma created in order to sell their statin drugs.

Cholesterol is mostly produced by the liver, no really the food we eat.

Our entire body and mainly the brain needs cholesterol to be able to function.

statins does not discriminate and will damage the liver.

a reply to: TheValeyard

oh, idk about all that , crispr tech is pretty cheap .. you have been able to diy for a while now. and nothing stays secret now days.

a reply to: SprocketUK

agreed lol i know people are freaked out but i for one am all for the great march forward ... give me biological immortality in my lifetime please lol

a reply to: marg6043

one death is to many , huh? well im glad you dont get to decide. with that attitude i dont know if humanity would have survived.

a reply to: Another_Nut

Thanks for the post, S&F. I read about this on NPR this morning. I have high LDL cholesterol. My doctor just doubled the dose of my atorvastatin. I've tried about everything to get that number down, and nothing seems to be working. I hope they can keep doing this research and have something that people like me can get to help. My entire mom's side of the family has had high cholesterol forever. And meds don't seem to help much.

a reply to: TheValeyard

Fair points .

And why spend all the time and money gene editing the proles, when you could gene edit yourself and build a new world for the super rich on another planet?

But who is gonna build it ? The Rich love there commodities and Healthy Foods but someone has to maintain and establish the commodities . Someone has to grow the food and wait hand a foot on the Rich .

The Rich are only Rich if they have the working class to make them seem Rich .

originally posted by: asabuvsobelow
a reply to: TheValeyard

Fair points .

The Rich are only Rich if they have the working class to make them seem Rich .

Then let them eat cake!

Cricket cake.

a reply to: asabuvsobelow


The poor, obviously, but what I'm saying is, if we're already giving them what they want as it is,
then why would they change anything for us?


You said they could make us immortal and curb over-population, well,
I think it'd make more sense to simply make a lot of us sterile, and make themselves immortal.
Would it not?

Shorter life-cycle means the person has a shorter period of time to "get wise",
and thus is easier to manipulate, while they, and only they, could grow vastly more knowledgeable through their time.

It appears that I have a problem with my body making cholestoral hereditarily. Genes that I have inherited. So I have to injest what I need. I have some genes that Inuit or eskimo men have, inherited from my great great great great grandfather on my fathers side it appears. He would have been an inuit or a person sharing similar genetics. Probably coming from somewhere near the ocean like far north siberia or greenland or something. I only have about one point seven percent Inuit genetics, but certain genes are still active. I cannot properly take apart starches or disaccharides. and cannot make omega threes or omega sixes so diet would restrict turning carbs into cholesterol or necessary lipids. This would explain my lifelong hypoglycemia issues I think.

So, no matter how high my cholestorol got, I would not take this medication. If there was not a supply of a proper mix of lipids in my diet I would have issues. The brain contains a lot of cholesterol dependency in it's function, lowering it too much would cause a life of dumbness.

But then again, because this is actually well known about it's use in the brain, I am sure that the people trying to lower levels a lot must be aware of the consequences. People who cannot think rationally are easier to control. Sheep well tonight.

Who had Zombie Apocalypse on their bingo card for 2024?

It`s just round 2 with the fake paradigm what says cholesterol bad .

The real culprit is something else than cholesterol, but are you really thinking they would tell you that .

Quote from the 1968 movie "Planet of the Apes".

George Taylor (Charlton Heston):
It's a mad house! A mad house!

a reply to: ChiefD

Glad to hear this may help you one day... And maybe one day soon ... US trials start next year.

a reply to: DBCowboy

Oh come on now dc...we know you would love to argue for the next thousand years lol

a reply to: ChiefD

Cholesterol is bad for you because they have pills that show results on tests in most people. The results mean nothing but the number goes down in most cases.

If you lower your cholesterol your brain will suffer because it is about 60% fat. Cholesterol is fat the human body needs in most cases.

Cholesterol medication is way too profitable to let this out into the public. It will disappear very soon.

These kinds of trials on the back of a pushed mass public vax campaign is going to make a lot of abominations. Looks like some want to learn what the code of life is about the hard way. With the way the RNA tech is going, feels like give a 5 year old access to the computers operating system source code with all the secrets, deception and special interests going on. A lot of mistakes are going to be made along the way. Is it going to be worth it?

Would having a stronger and deeper comprehension of how all this code works first help in finding fixes where required and shaping the next generation in a more sustainable way?

With the results of the vax so far, mRNA is looking to go the way of steroids. There is a short term benefit, but when athletes start dropping on the field there are problems. Maybe it will work for a few in special circumstances, but with how informed consent has been suppressed it has trouble all over it.

a reply to: DBCowboy


I uploaded a bunch of Illuminati Playing cards so I could link them in comments.
Been waiting for an excuse to use one.
Thanks for that.

originally posted by: Another_Nut
a reply to: ChiefD

Glad to hear this may help you one day... And maybe one day soon ... US trials start next year.

a reply to: DBCowboy

Oh come on now dc...we know you would love to argue for the next thousand years lol

A thousand years like I am now?

Pass.

Now a thousand years when I was 30?

Pass again.