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The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD,but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells.
This study highlights CBD as a potential preventative agent for early-stage SARS-CoV-2 infection and merits future clinical trials. We caution against use of non-medical formulations including edibles, inhalants or topicals as a preventative or treatment therapy at the present time.
*CBD effectively eradicated viral RNA expression in the host cells
*Prevents changes in the cell produced by the virus to force the cell to produce new viral particles
*CBD induces strong activation of genes associated with the host stress response.
*Together, these results suggest that CBD acts to prevent viral protein translation and associated cellular changes.
*Induction of viral genes for spike, envelope, and nucleocapsid proteins is reduced ~99% with CBD
This study highlights CBD as a potential preventative agent for early-stage SARS-CoV-2 infection and merits future clinical trials. We caution against use of non-medical formulations including edibles, inhalants or topicals as a preventative or treatment therapy at the present time.
originally posted by: datguy
a reply to: CoyoteAngels
I had not really noticed in the mix of it all, but in hindsight I have to confirm this anecdotal evidence.
While Cannabis does not have the high potency CBD as is found in Hemp, as a preventative measure I suppose a frequent user of Cannabis would have higher levels of CBD in their system.
originally posted by: CoyoteAngels
a reply to: datguy
Thats interesting. Cannabis should have been studied all these years instead of demonized. Maybe that's why it was?
originally posted by: CoyoteAngels
a reply to: datguy
I don't know one pot smoker that died from covid or had more than a bad cold. But I know what they say about anecdotes.