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originally posted by: Rich Z
Sheesh.... I wrote to Moffitt asking them if they offered dendritic cell therapy or if not, who they could recommend, inside or outside of the USA. So I get a reply back claiming that they don't know of anyone using it. I guess they don't get out very much there........ :/
Possibly because it has a low success rate (3 in 10) and requires a genetic test to see if it's even possible to offer it.
www.ncbi.nlm.nih.gov...
Artemisinin and its derivatives are produced from the medicinal herb Artemisia annua. They constitute a class of potent antimalarial drugs. Some of these compounds have already been used for many years in areas in which malaria is endemic, mainly in Asia, and are currently undergoing phase II or phase III studies in other areas. Studies in China, Vietnam, and Thailand have shown that artemisinin and derivatives quickly reduce parasitemia in patients with acute falciparum malaria and induce fast resolution of symptoms (10, 11, 13, 17, 19, 22).
Dosage regimens have largely been determined empirically. Few pharmacokinetic data are available to aid the development of rational dosage regimens, which is partly attributable to limited access to a sensitive and specific assay for measuring the concentration of artemisinin in plasma. A recently developed accurate high-performance liquid chromatography (HPLC) technique with electrochemical detection has now enabled additional studies (4, 12, 20).
In a previous study of the pharmacokinetics of artemisinin after a single 500-mg oral dose on an empty stomach in healthy Vietnamese subjects, it was found that absorption of artemisinin was rapid but probably incomplete, yielding peak concentrations of 289 to 734 ng z ml21 (4). Very high values for the apparent volume of distribution/bioavailability ratio (V/f) and clearance/bioavailability ratio (Cl/f) were found. Mean 6 standard deviation (SD) elimination was rapid, with a half-life of 2.6 6 0.6 h. The in vitro MIC of artemisinin for Plasmodium falciparum is 3 to 30 ng z ml21 (8, 9, 18, 23). Plasma drug concentrations were higher than the MIC for up to 12 h after dosage. Since the bioavailability of artemisinin is probably low, influences on absorption might have implications for efficacy. An important aspect of therapy is that artemisinin, a treatment for acute disease, will be administered irrespective of recent food intake. Artemisinin is neither very water soluble nor lipid soluble. Food intake could be a major determinant of absorption. Apart from its influence on absorption, food intake could also affect hepatic clearance by stimulation of liver blood flow, since hepatic clearance is probably the most important route of elimination for artemisinin (15, 16, 21).
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naturalnews.com...
(Related: Artemisinin is also a remedy for malaria, several localized cases of which have emerged in Florida and Texas.)
Artemisinins are safer and arguably more effective than chemotherapy and radiation
It was Nobel Prize winner and eminent Chinese scientist Prof. Youyou Tu who four decades ago first discovered that artemisinin is a powerful remedy for malaria. The drug class is used all around the world to mitigate the disease.
Since then, the artemisinin class of drugs has continued to intrigue scientists and medical professionals because they recognize that its repurpose potential as a novel therapeutic agent for other conditions is strong.
"Artemisinins are a remarkable class of compounds that have shown promising cytotoxic effects against viruses, fungi and a variety of cancers as well as powerful anti-inflammatory effects in animal models of asthma, sepsis, arthritis, pancreatitis, systemic lupus erythematosus and haemorrhagic shock," the paper explains, citing a litany of sources to back their use for each of these unique purposes.
Keep in mind that, despite being labeled as "drugs," artemisinins are technically natural in that they are derived from sweet wormwood (Artemisia annua L.). They represent a family of sesquiterpene trioxane agents that contain an active metabolite known as dihydroartemisinin, or DHA for short.
"Artesunate, artemether and arteether are derivatives of artemisinin that are wholly or partially converted into the active metabolite dihydroartemisinin (DHA)," the study reveals.
"Sweet wormwood (qinghao) has been used in traditional Chinese medicine for two millennia to treat fevers and a variety of inflammatory conditions. Humanity has probably wrestled with the life-threatening global epidemic of malaria since as far back as 770 BCE with a detailed description of symptoms of malaria described in the Inner Canon of the Yellow Emperor, written around the time of the Chun Qiu and Qin Dynasties (770–207 B·C.)."
Renowned Chinese physician Ge Hong (284-363) listed qinghaosu as an essential remedy for fevers in the publication Emergency Prescriptions Kept up one's Sleeve. He also wrote a treatise called "On Airs, Waters, and Places" in 400 B.C. when Hippocrates was describing "agues" and "tertian fevers" as frequently affecting people who lived close to swamps and marshlands where mosquitoes happen to live and breed.
Fast-forward to today and artemisinins are not only being used to treat malaria but also cancer.
"The antimalarial quinine was used in the early 20th century as an anti-arrhythmic agent to treat atrial fibrillation," the study explains.
"Difluoromethylornithine (DFMO) which was originally developed as an anti-cancer therapy has been repurposed as a treatment for sleeping sickness. To date there are over 100 candidate drugs undergoing drug repurposing clinical trials for cancer."
"An artemisinin drug repurposing programme for a number of cancer types, with a variety of clinical settings and combination therapies from pump priming window studies to Phase III clinical trials is urgently needed."
Looking for more information about how to deal with cancer naturally?
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www.sciencedirect.com...
4. Artemisinins: Multiple modes of action against cancer
Carcinogenesis in humans is a complex process and 8 key hallmarks have been well described (Hanahan & Weinberg, 2011). These include sustained proliferative signaling, evasion of cell death and growth suppression, induction of angiogenesis, invasion and metastasis, reprogramming energy metabolism and evasion of immune destruction (Hanahan & Weinberg, 2011). In the last three decades, artemisinins have shown potent and broad anticancer properties in a range of cell lines and animal models...
originally posted by: Rich Z
Rather interesting how many anti-parasitic drugs seem to have anti-cancer properties, eh? Makes you wonder.......
originally posted by: Rich Z
My wife was diagnosed with stage 4 ovarian cancer just over a year ago. She had surgery to remove three masses and any related tissues that appeared to have "disease". Then she went on chemo for six cycles (with a break in between caused by the original oncologist dragging her feet while making a chemo change she wanted to progress to. So the wife actually finished up the chemo regimen with a second oncologist, and then went on to taking only Avastin as supposedly a maintenance program. But she never had her CA125 tumor marker test drop down into the "normal" level. And now for the past few blood tests, that number is rising steadily. CT scans show no tumors, but we recently found out that ovarian cancer will sometimes (often") spread as a sheet across and around organs instead of forming three dimensional tumors. My wife has had to have fluid drained from the sack around her right lung (pleural effusion) several times, and there might now be fluid possibly building up in both lung sacks. The fluid that was drained was confirmed to contain cancer cell.
Really not crazy about just going through more chemo treatments as the standard oncologists here in the USA apparently believe in trying to get as close to killing the patient as they can, hoping that the cancer will die before the patient does. We have been reading a LOT about alternative treatments, and honestly after the fiasco with the FDA stomping hard on Ivermectin and other drugs in order to push the vaccines, I have developed a lot of distrust for what the FDA permits doctors to use and not to use. It doesn't take a big leap of thought to assume that this sort of filtering is taking place within the cancer industry as well.
But what to believe? There is so much biased information and counter information available, that picking the wheat from the chaff is nearly impossible to do. As a for instance, my wife is seriously considering going to Tijuana Mexico -> www.oasisofhope.com... because of a personal recommendation from someone she talked to personally who has been there and highly recommended it. But heck, there are lots of negative reviews as well as positive ones. Which ones are truthful and which ones are just planted trolls by the powers who would rather not have any competing alternatives to suck away the profits of the pharmaceutical companies?
So here is the thing. If my wife is convinced this Tijuana junket will help, and it is NOT cheap, how in the world can I say to her, "No, sorry, but I don't believe it will help you" when I certainly don't know that at all. And would she resent my standing in the way of her MAYBE getting better, or at least living a few more years longer than she will otherwise?
I guess I am asking for input from anyone who has first hand (or relatively so) with any alternate source of therapies that had a successful (relatively speaking) resolution. Surely some are legit? Or are they all just trying to sell snake oil to grab as much money as they can from desperate people at their most desperate times?
Any advice would be GREATLY, GREATLY appreciated. My wife actually feels pretty good now, but I don't know how much of this borrowed time she has left before things get worse. Stage 4 ovarian cancer does not have a good track record for survivability of the victims. After being married to this woman, who is also my best friend, for 45 years, I would like to keep her around as long as possible.
.so I started taking 100mg Mebendazole tablets 3 times a day ,200 mg cimetidine tablets 4 times a day www.canceractive.com... and 50 grams of Glutamine power twice a day.
originally posted by: Rich Z
Connie wants to give the protocol recommended by Oasis Of Health a shot. She has had dendritic cell therapy that ended on 07-13-2023. She is supposed to wait three weeks for those dendritic cells to establish themselves, and then begin a regimen of light dose chemo drugs orally along with various nutrients and supplements.
Meanwhile, she had a PET scan on 07-24-2023 that shows that her cancer has spread quite a bit within her torso. Not into the bones, however.
I actually bought mebendazole for her, and she was taking it, along with some other researched supplements before she went to Tijuana. Right before her trip, her CA125 number had leveled off and even dropped a slight bit. 4200 something. Her latest CA125 blood test, taken on 07-17-2024 showed that the number had risen to over 10,000. Normal is considered as being less than 35.
Here is the dilemma I face. If I believe that Mebendazole would save her and force her to abandon the Oasis of Health plan, and she dies, would the guilt crush me thinking that MAYBE that Oasis plan WOULD have worked had I let it? But on the other hand, if I let her have the path she wants to take and she dies, would I be crushed with guilt because I didn't STOP her to go back to Mebendazole?
Of course, the best course would be for her to have things turn around and she just gets better. Otherwise, well, we could be in for a very rough road ahead. Mine likely to be a lot longer than hers.
If only I could just wake up to find this was the worst nightmare EVER.................