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originally posted by: anonentity
a reply to: nugget1
This data seems to be very robust, so the implications will be profound. It seems to be stabilizing at about 23% in excess deaths.
originally posted by: nugget1
originally posted by: anonentity
a reply to: nugget1
This data seems to be very robust, so the implications will be profound. It seems to be stabilizing at about 23% in excess deaths.
We're being led to believe that the majority of deaths have been in the elderly community but I'm not convinced. After all the lies and false information I'm going to need to see some real, honest facts and figures.
originally posted by: billxam
It should be noted that the website he has, financetechnologies.com, does not exist. At Godaddy financetechnologies.com shows as for sale. I thought that maybe I misheard and tried various spellings, financialtechnologies, financetechnologies. If you try financetechnology.com it times out.
originally posted by: BernnieJGato
a reply to: anonentity
well i don't know about all the money aspect of it, nor was it of much concern at the time. once i found out mRNA vaccines talk / tell / teach your DNA to make something instead of your natural immune systems responding to what ever the foreign invaders of your body was in the traditional way vaccines were made or none at all. which has worked for oh how many millions of years or at least say the past 96 years.
i said to myself, self anything that communicates with your DNA can and most likely will blank you up in some way or another. it may not be right now, could be years down the road. tell the sob money mongers the worlders like gates, ze bug man schwab, smilin francis, and little fauci to kiss your A@@!
Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair Pols efficiently use template ribonucleotides and promote RNA-templated DNA repair synthesis remains unknown. We find that human Polθ reverse transcribes RNA, similar to retroviral reverse transcriptases (RTs). Polθ exhibits a significantly higher velocity and fidelity of deoxyribonucleotide incorporation on RNA versus DNA. The 3.2-Å crystal structure of Polθ on a DNA/RNA primer-template with bound deoxyribonucleotide reveals that the enzyme undergoes a major structural transformation within the thumb subdomain to accommodate A-form DNA/RNA and forms multiple hydrogen bonds with template ribose 2′-hydroxyl groups like retroviral RTs. Last, we find that Polθ promotes RNA-templated DNA repair in mammalian cells. These findings suggest that Polθ was selected to accommodate template ribonucleotides during DNA repair.
This research was supported by NIH grants 1R01GM130889-01 and 1R01GM137124-01, and R01CA197506 and R01CA240392. This research was also supported in part by a Tower Cancer Research Foundation grant. The authors report no conflicts of interest.
New Discovery Shows Human Cells Can Write RNA Sequences Into DNA – Challenges Central Principle in Biology
Abstract
DNA polymerases play a central role in biology by transferring genetic information from one generation to the next during cell division. Harnessing the power of these enzymes in the laboratory has fueled an increase in biomedical applications that involve the synthesis, amplification, and sequencing of DNA. However, the high substrate specificity exhibited by most naturally occurring DNA polymerases often precludes their use in practical applications that require modified substrates. Moving beyond natural genetic polymers requires sophisticated enzyme-engineering technologies that can be used to direct the evolution of engineered polymerases that function with tailor-made activities. Such efforts are expected to uniquely drive emerging applications in synthetic biology by enabling the synthesis, replication, and evolution of synthetic genetic polymers with new physicochemical properties.
Engineering polymerases for applications in synthetic biology