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A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial. The vaccine, developed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, could someday be an important tool to respond to Marburg virus outbreaks.
This first-in-human, Phase 1 study tested an experimental MARV vaccine candidate, known as cAd3-Marburg, which was developed at NIAID’s Vaccine Research Center (VRC). This vaccine uses a modified chimpanzee adenovirus called cAd3, which can no longer replicate or infect cells, and displays a glycoprotein found on the surface of MARV to induce immune responses against the virus. The cAd3 vaccine platform demonstrated a good safety profile in prior clinical trials when used in investigational Ebola virus and Sudan virus vaccines developed by the VRC.
Equatorial Guinea "declares today the health alert for a Marburg hemorrhagic fever in the province of Kie-Ntem and in the (neighboring) district of Mongomo," said the minister.
A "containment plan has been put in place" in close collaboration with the UN World Health Organization (WHO) "to deal with the epidemic" in this area covered by dense equatorial forest in the eastern part of the country's mainland, which also includes two main islands.
The Marburg virus is transmitted to humans by fruit bats and is spread in humans through direct contact with the body fluids of infected persons, or with surfaces and materials.
originally posted by: nugget1
I wonder if the 'vaccine' will make one three times more likely to get Marburg again and again
The Marburg virus is transmitted to humans by fruit bats and is spread in humans through direct contact with the body fluids of infected persons, or with surfaces and materials.